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Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy

The traditional use of papaya to treat many diseases, especially skin conditions and its prohibition for consumption during pregnancy has prompted us to determine whether papaya extracts both from green and ripe fruits improve wound healing and also produce foetal toxicity. Aqueous extracts of green...

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Main Authors:	Anuar, Nor Suhada, Zahari, Shaﬁyyah Solehah, Taib, Ibrahim Adham, Rahman, Mohammad Tariqur
Format:	Article
Language:	English
Published:	Elsevier Limited 2008
Subjects:	QM Human anatomy
Online Access:	http://irep.iium.edu.my/29705/1/Food_Chem_Toxicol.pdf http://irep.iium.edu.my/29705/ http://www.sciencedirect.com/science/article/pii/S0278691508001518
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spelling	my.iium.irep.297052013-08-02T06:49:42Z http://irep.iium.edu.my/29705/ Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy Anuar, Nor Suhada Zahari, Shaﬁyyah Solehah Taib, Ibrahim Adham Rahman, Mohammad Tariqur QM Human anatomy The traditional use of papaya to treat many diseases, especially skin conditions and its prohibition for consumption during pregnancy has prompted us to determine whether papaya extracts both from green and ripe fruits improve wound healing and also produce foetal toxicity. Aqueous extracts of green papaya epicarp (GPE) and ripe papaya epicarp (RPE) were applied on induced wounds on mice. GPE treatment induced complete healing in shorter periods (13 days) than that required while using RPE (17 days), sterile water (18 days) and Solcoseryl ointment (21 days). Extracts were administered orally (1 mg/g body weight/day) to pregnant mice from day 10 and onwards after conception. 3 (n = 7) mice and 1 (n = 6) mice given RPE and misoprostol, an abortive drug, respectively experienced embryonic resorption while this effect was observed in none of the mice given GPE (n = 5) and water (n = 5). The average body weight of live pups delivered by mice given GPE (1.12 +/- 0.04 g) was significantly lower than those delivered by mice given water (1.38 +/- 0.02 g). In SDS-PAGE, proteins were distributed in three bands (Mr range similar to 8-29 kDa). Band intensity at Mr similar to 28-29 kDa was higher in GPE than in RPE. In contrast, band intensity at low Mr (similar to 8 kDa) was found to be higher in RPE than in GPE. Notably, the band corresponding to Mr similar to 23-25 kDa was absent in RPE. These differences in composition may have contributed to the different wound healing and abortive effects of green and ripe papaya Elsevier Limited 2008-07 Article REM application/pdf en http://irep.iium.edu.my/29705/1/Food_Chem_Toxicol.pdf Anuar, Nor Suhada and Zahari, Shaﬁyyah Solehah and Taib, Ibrahim Adham and Rahman, Mohammad Tariqur (2008) Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy. Food and chemical toxicology, 46 (7). pp. 2384-2389. ISSN 0278-6915 http://www.sciencedirect.com/science/article/pii/S0278691508001518 10.1016/j.fct.2008.03.025
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	QM Human anatomy
spellingShingle	QM Human anatomy Anuar, Nor Suhada Zahari, Shaﬁyyah Solehah Taib, Ibrahim Adham Rahman, Mohammad Tariqur Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy
description	The traditional use of papaya to treat many diseases, especially skin conditions and its prohibition for consumption during pregnancy has prompted us to determine whether papaya extracts both from green and ripe fruits improve wound healing and also produce foetal toxicity. Aqueous extracts of green papaya epicarp (GPE) and ripe papaya epicarp (RPE) were applied on induced wounds on mice. GPE treatment induced complete healing in shorter periods (13 days) than that required while using RPE (17 days), sterile water (18 days) and Solcoseryl ointment (21 days). Extracts were administered orally (1 mg/g body weight/day) to pregnant mice from day 10 and onwards after conception. 3 (n = 7) mice and 1 (n = 6) mice given RPE and misoprostol, an abortive drug, respectively experienced embryonic resorption while this effect was observed in none of the mice given GPE (n = 5) and water (n = 5). The average body weight of live pups delivered by mice given GPE (1.12 +/- 0.04 g) was significantly lower than those delivered by mice given water (1.38 +/- 0.02 g). In SDS-PAGE, proteins were distributed in three bands (Mr range similar to 8-29 kDa). Band intensity at Mr similar to 28-29 kDa was higher in GPE than in RPE. In contrast, band intensity at low Mr (similar to 8 kDa) was found to be higher in RPE than in GPE. Notably, the band corresponding to Mr similar to 23-25 kDa was absent in RPE. These differences in composition may have contributed to the different wound healing and abortive effects of green and ripe papaya
format	Article
author	Anuar, Nor Suhada Zahari, Shaﬁyyah Solehah Taib, Ibrahim Adham Rahman, Mohammad Tariqur
author_facet	Anuar, Nor Suhada Zahari, Shaﬁyyah Solehah Taib, Ibrahim Adham Rahman, Mohammad Tariqur
author_sort	Anuar, Nor Suhada
title	Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy
title_short	Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy
title_full	Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy
title_fullStr	Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy
title_full_unstemmed	Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy
title_sort	effect of green and ripe carica papaya epicarp extracts on wound healing and during pregnancy
publisher	Elsevier Limited
publishDate	2008
url	http://irep.iium.edu.my/29705/1/Food_Chem_Toxicol.pdf http://irep.iium.edu.my/29705/ http://www.sciencedirect.com/science/article/pii/S0278691508001518
_version_	1643609741511884800
score	13.211869

Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy

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