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Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience

Background: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on microscopic marginal status. Met...

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Main Authors: Sharifudin, Mohd Ariff, Wan, Zulmi, Wan Ismail, Wan Faisham Numan, Mat Zin, Nor Azman, Mohamed Amir, Nawaz Hussain
Format: Article
Language:English
English
English
Published: Malaysian Orthopaedic Association 2012
Subjects:
RB Pathology
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
RD701 Orthopedics
Online Access:http://irep.iium.edu.my/29399/17/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Cover%29.pdf
http://irep.iium.edu.my/29399/18/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Content_Page_30%29.pdf
http://irep.iium.edu.my/29399/22/Surgical_Margin_Abstract.pdf
http://irep.iium.edu.my/29399/
http://moa-home.com/moa2012/index.htm
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spelling my.iium.irep.293992013-03-07T02:06:11Z http://irep.iium.edu.my/29399/ Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics Background: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on microscopic marginal status. Method: We analyzed 53 consecutive patients surgically treated throughout a 10-year span at a single referral centre between 2001 and 2010. Various clinicopathologic factors were analyzed in relation to the oncological outcomes of overall survival and local recurrence. Results: Majority of cases were primary tumours (90%). Chondrosarcoma (n = 11) and osteosarcoma (n = 10) were the most common diagnoses. Eighteen patients underwent external hemipelvectomy and 35 patients were subjected to internal hemipelvectomy resection of various types. Average age was 40.12 years (range: 12-79 years). Average follow up is 10.4 months (range: 0-108 months). Thirty-seven patients underwent macroscopically wide resection but only 46% had clear marginal statuses. Conclusion: Positive surgical margins had a weak adverse prognostic effect, which was more pronounced for those patients escaping an early relapse. Other prognostic factors and relation to the oncological outcomes are further outlined in the article. Malaysian Orthopaedic Association 2012-06-17 Article REM application/pdf en http://irep.iium.edu.my/29399/17/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Cover%29.pdf application/pdf en http://irep.iium.edu.my/29399/18/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Content_Page_30%29.pdf application/pdf en http://irep.iium.edu.my/29399/22/Surgical_Margin_Abstract.pdf Sharifudin, Mohd Ariff and Wan, Zulmi and Wan Ismail, Wan Faisham Numan and Mat Zin, Nor Azman and Mohamed Amir, Nawaz Hussain (2012) Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience. Malaysian Orthopaedic Journal, 6 (2sup.A). p. 35. ISSN 1985-2533 http://moa-home.com/moa2012/index.htm
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic RB Pathology
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
RD701 Orthopedics
spellingShingle RB Pathology
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
RD701 Orthopedics
Sharifudin, Mohd Ariff
Wan, Zulmi
Wan Ismail, Wan Faisham Numan
Mat Zin, Nor Azman
Mohamed Amir, Nawaz Hussain
Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
description Background: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on microscopic marginal status. Method: We analyzed 53 consecutive patients surgically treated throughout a 10-year span at a single referral centre between 2001 and 2010. Various clinicopathologic factors were analyzed in relation to the oncological outcomes of overall survival and local recurrence. Results: Majority of cases were primary tumours (90%). Chondrosarcoma (n = 11) and osteosarcoma (n = 10) were the most common diagnoses. Eighteen patients underwent external hemipelvectomy and 35 patients were subjected to internal hemipelvectomy resection of various types. Average age was 40.12 years (range: 12-79 years). Average follow up is 10.4 months (range: 0-108 months). Thirty-seven patients underwent macroscopically wide resection but only 46% had clear marginal statuses. Conclusion: Positive surgical margins had a weak adverse prognostic effect, which was more pronounced for those patients escaping an early relapse. Other prognostic factors and relation to the oncological outcomes are further outlined in the article.
format Article
author Sharifudin, Mohd Ariff
Wan, Zulmi
Wan Ismail, Wan Faisham Numan
Mat Zin, Nor Azman
Mohamed Amir, Nawaz Hussain
author_facet Sharifudin, Mohd Ariff
Wan, Zulmi
Wan Ismail, Wan Faisham Numan
Mat Zin, Nor Azman
Mohamed Amir, Nawaz Hussain
author_sort Sharifudin, Mohd Ariff
title Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_short Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_full Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_fullStr Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_full_unstemmed Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_sort surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of husm experience
publisher Malaysian Orthopaedic Association
publishDate 2012
url http://irep.iium.edu.my/29399/17/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Cover%29.pdf
http://irep.iium.edu.my/29399/18/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Content_Page_30%29.pdf
http://irep.iium.edu.my/29399/22/Surgical_Margin_Abstract.pdf
http://irep.iium.edu.my/29399/
http://moa-home.com/moa2012/index.htm
_version_ 1643609671081132032
score 13.211869

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