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Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom

Snake bite has been regarded as an important health problem in Myanmar since early 1960's. In the recent years, there has been growing interest in alternative therapies and therapeutic use of natural products, especially those derive from plants. In Myanmar and Indian traditional medicine, vari...

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Main Authors: Khin, Maung Maung, Zaw, Lynn Aung
Format: Article
Language:English
Published: Malaysian Society of Parasitology and Tropical Medicine 2012
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/28979/1/Tropical_Biomedicine.pdf
http://irep.iium.edu.my/28979/
http://www.msptm.org/journal24.html
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spelling my.iium.irep.289792013-07-05T03:28:02Z http://irep.iium.edu.my/28979/ Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom Khin, Maung Maung Zaw, Lynn Aung R Medicine (General) Snake bite has been regarded as an important health problem in Myanmar since early 1960's. In the recent years, there has been growing interest in alternative therapies and therapeutic use of natural products, especially those derive from plants. In Myanmar and Indian traditional medicine, various plants have used as a remedy for treating snake bite. The present study was carried out to evaluate the effects of alcohol extract of Tamarind (Tamarindus indica Linn.) seed on some biologic properties of Russell's viper (Daboia russelli siamensis) venom (RVV). The Phospholipase A2 (PLA2) enzyme, coagulase enzyme and caseinolytic enzyme activities of Russell's viper venom (RVV) were reduced when mixed and incubated with the extract. When the RVV and the different amount of extracts were preincubated and injected intramuscularly into mice, all of them survived, but all the mice in the control group died. On the other hand, when RVV were injected first followed by the extract into mice, all of them died. If the extract was injected near the site where Russell's viper venom was injected, all the mice survived for more than 24 hours and the survival time prolonged but they all died within 96 hours. In conclusion, according to the results obtained, the extract neutralizes some biologic properties of the Russell's viper venom and prolonged the survival time if the extract was injected near the site where the Russell's viper venom was injected. Malaysian Society of Parasitology and Tropical Medicine 2012 Article REM application/pdf en http://irep.iium.edu.my/28979/1/Tropical_Biomedicine.pdf Khin, Maung Maung and Zaw, Lynn Aung (2012) Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom. Tropical Biomedicine, 29 (4). pp. 580-587. ISSN 0127-5720 http://www.msptm.org/journal24.html
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Khin, Maung Maung
Zaw, Lynn Aung
Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom
description Snake bite has been regarded as an important health problem in Myanmar since early 1960's. In the recent years, there has been growing interest in alternative therapies and therapeutic use of natural products, especially those derive from plants. In Myanmar and Indian traditional medicine, various plants have used as a remedy for treating snake bite. The present study was carried out to evaluate the effects of alcohol extract of Tamarind (Tamarindus indica Linn.) seed on some biologic properties of Russell's viper (Daboia russelli siamensis) venom (RVV). The Phospholipase A2 (PLA2) enzyme, coagulase enzyme and caseinolytic enzyme activities of Russell's viper venom (RVV) were reduced when mixed and incubated with the extract. When the RVV and the different amount of extracts were preincubated and injected intramuscularly into mice, all of them survived, but all the mice in the control group died. On the other hand, when RVV were injected first followed by the extract into mice, all of them died. If the extract was injected near the site where Russell's viper venom was injected, all the mice survived for more than 24 hours and the survival time prolonged but they all died within 96 hours. In conclusion, according to the results obtained, the extract neutralizes some biologic properties of the Russell's viper venom and prolonged the survival time if the extract was injected near the site where the Russell's viper venom was injected.
format Article
author Khin, Maung Maung
Zaw, Lynn Aung
author_facet Khin, Maung Maung
Zaw, Lynn Aung
author_sort Khin, Maung Maung
title Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom
title_short Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom
title_full Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom
title_fullStr Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom
title_full_unstemmed Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom
title_sort effects of tamarind (tamarindus indicus linn) seed extract on russell's viper (daboia russelli siamensis) venom
publisher Malaysian Society of Parasitology and Tropical Medicine
publishDate 2012
url http://irep.iium.edu.my/28979/1/Tropical_Biomedicine.pdf
http://irep.iium.edu.my/28979/
http://www.msptm.org/journal24.html
_version_ 1643609585644208128
score 13.211869

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