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Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine

Ketamine abuse is on the increase in Malaysia. Neurodegenerative change following ketamine use results in debilitating behavioural and cognitive dysfunctions. These changes are thought to be the consequences of network and cellular disorganization and degeneration in the brain involving areas such...

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Main Authors: Mohd Shafri, Mohd Affendi, Mat Jais, Abdul Manan, Md. Jaffri, Juliana, Min, Kyu Kim, Ithnin, Hairuszah, Mohamed, Farahidah
Format: Article
Language:English
Published: Academic Sciences 2012
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/27822/1/Cresyl_violet_staining_to_assess_neuroprotective.pdf
http://irep.iium.edu.my/27822/
http://www.ijppsjournal.com/Vol4Issue4/4747.pdf
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spelling my.iium.irep.278222022-12-09T02:41:30Z http://irep.iium.edu.my/27822/ Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine Mohd Shafri, Mohd Affendi Mat Jais, Abdul Manan Md. Jaffri, Juliana Min, Kyu Kim Ithnin, Hairuszah Mohamed, Farahidah R Medicine (General) Ketamine abuse is on the increase in Malaysia. Neurodegenerative change following ketamine use results in debilitating behavioural and cognitive dysfunctions. These changes are thought to be the consequences of network and cellular disorganization and degeneration in the brain involving areas such as hippocampus. Ketamine works by blocking NMDA receptor and hence ketamine research has value in study on NMDA-related neurological disorders such as schizophrenia. This work study the histological change in rats brain which was exposed to ketamine and the effect of treating ketamine-exposed rats with haruan traditional extract (HTE) a substance which has been shown to have positive neuroregenerative function in cell culture study. The changes were studied using cresyl violet and parameters such as pathological score, dead cell count and degenerative change were evaluated. It was demonstrated that ketamine influences these parameters in exposure length-dependent manners and degenerative change could be ameliorated by supplementation with haruan therapeutic extract (HTE) pre-damage induction but not post-damage induction. The result adds to the growing number of evidence on neuroplasticity, and the possible role of non-endogenous substances in protecting as well as inducing genesis of neurons for diseases that share similar pattern of neurological change as ketamine-abused subjects. Academic Sciences 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/27822/1/Cresyl_violet_staining_to_assess_neuroprotective.pdf Mohd Shafri, Mohd Affendi and Mat Jais, Abdul Manan and Md. Jaffri, Juliana and Min, Kyu Kim and Ithnin, Hairuszah and Mohamed, Farahidah (2012) Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4). pp. 163-168. ISSN 0975-1491 http://www.ijppsjournal.com/Vol4Issue4/4747.pdf
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Mohd Shafri, Mohd Affendi
Mat Jais, Abdul Manan
Md. Jaffri, Juliana
Min, Kyu Kim
Ithnin, Hairuszah
Mohamed, Farahidah
Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
description Ketamine abuse is on the increase in Malaysia. Neurodegenerative change following ketamine use results in debilitating behavioural and cognitive dysfunctions. These changes are thought to be the consequences of network and cellular disorganization and degeneration in the brain involving areas such as hippocampus. Ketamine works by blocking NMDA receptor and hence ketamine research has value in study on NMDA-related neurological disorders such as schizophrenia. This work study the histological change in rats brain which was exposed to ketamine and the effect of treating ketamine-exposed rats with haruan traditional extract (HTE) a substance which has been shown to have positive neuroregenerative function in cell culture study. The changes were studied using cresyl violet and parameters such as pathological score, dead cell count and degenerative change were evaluated. It was demonstrated that ketamine influences these parameters in exposure length-dependent manners and degenerative change could be ameliorated by supplementation with haruan therapeutic extract (HTE) pre-damage induction but not post-damage induction. The result adds to the growing number of evidence on neuroplasticity, and the possible role of non-endogenous substances in protecting as well as inducing genesis of neurons for diseases that share similar pattern of neurological change as ketamine-abused subjects.
format Article
author Mohd Shafri, Mohd Affendi
Mat Jais, Abdul Manan
Md. Jaffri, Juliana
Min, Kyu Kim
Ithnin, Hairuszah
Mohamed, Farahidah
author_facet Mohd Shafri, Mohd Affendi
Mat Jais, Abdul Manan
Md. Jaffri, Juliana
Min, Kyu Kim
Ithnin, Hairuszah
Mohamed, Farahidah
author_sort Mohd Shafri, Mohd Affendi
title Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_short Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_full Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_fullStr Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_full_unstemmed Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_sort cresyl violet staining to assess neuroprotective and euroregenerative effects of haruan traditional extract against eurodegenerative damage of ketamine
publisher Academic Sciences
publishDate 2012
url http://irep.iium.edu.my/27822/1/Cresyl_violet_staining_to_assess_neuroprotective.pdf
http://irep.iium.edu.my/27822/
http://www.ijppsjournal.com/Vol4Issue4/4747.pdf
_version_ 1752146269366648832
score 13.211869

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