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Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review

Together with the permeability, the solubility of a drug plays an important role in determining its oral bioavailability. Nowadays, a majority of the new chemical entities are poorly water soluble candidates. For formulation scientists, it is a big deal to handle those drug candidates in order to fo...

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Main Author: Mandal, Uttam Kumar
Format: Book Chapter
Language:English
Published: IIUM Press 2011
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/25605/1/CHAPTER_9%5B1%5D.pdf
http://irep.iium.edu.my/25605/
http://rms.research.iium.edu.my/bookstore/default.aspx
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spelling my.iium.irep.256052012-08-27T07:42:51Z http://irep.iium.edu.my/25605/ Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review Mandal, Uttam Kumar RS Pharmacy and materia medica Together with the permeability, the solubility of a drug plays an important role in determining its oral bioavailability. Nowadays, a majority of the new chemical entities are poorly water soluble candidates. For formulation scientists, it is a big deal to handle those drug candidates in order to formulate a stable pharmaceutical dosage form with appropriate bioavailability. To increase the oral bioavailability of poorly soluble drugs, so far formulation scientists have adopted many chemical and formulation approaches. Out of those approaches, solid dispersion has played an important role for the past few decades. There are many formulation strategies employed to prepare solid dispersions. Solid dispersion mainly increases solubility and dissolution characteristics and thereby also oral bioavailability of poorly soluble drugs. The present review article deals with different strategies of solid dispersion preparation techniques, problems associated with those techniques and how to overcome them in order to improve the solubility as well as bioavailability ofpoorly water soluble drugs. IIUM Press 2011 Book Chapter REM application/pdf en http://irep.iium.edu.my/25605/1/CHAPTER_9%5B1%5D.pdf Mandal, Uttam Kumar (2011) Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review. In: Current Issues in Pharmacy. IIUM Press, Kuala Lumpur , pp. 156-177. ISBN 9789674180195 http://rms.research.iium.edu.my/bookstore/default.aspx
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Mandal, Uttam Kumar
Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review
description Together with the permeability, the solubility of a drug plays an important role in determining its oral bioavailability. Nowadays, a majority of the new chemical entities are poorly water soluble candidates. For formulation scientists, it is a big deal to handle those drug candidates in order to formulate a stable pharmaceutical dosage form with appropriate bioavailability. To increase the oral bioavailability of poorly soluble drugs, so far formulation scientists have adopted many chemical and formulation approaches. Out of those approaches, solid dispersion has played an important role for the past few decades. There are many formulation strategies employed to prepare solid dispersions. Solid dispersion mainly increases solubility and dissolution characteristics and thereby also oral bioavailability of poorly soluble drugs. The present review article deals with different strategies of solid dispersion preparation techniques, problems associated with those techniques and how to overcome them in order to improve the solubility as well as bioavailability ofpoorly water soluble drugs.
format Book Chapter
author Mandal, Uttam Kumar
author_facet Mandal, Uttam Kumar
author_sort Mandal, Uttam Kumar
title Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review
title_short Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review
title_full Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review
title_fullStr Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review
title_full_unstemmed Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review
title_sort pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review
publisher IIUM Press
publishDate 2011
url http://irep.iium.edu.my/25605/1/CHAPTER_9%5B1%5D.pdf
http://irep.iium.edu.my/25605/
http://rms.research.iium.edu.my/bookstore/default.aspx
_version_ 1643608968828813312
score 13.211869

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