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Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves

The objective of the present study was to determine the hepatoprotective activity of methanol extract of Bauhinia purpurea L. leaves (MEBP ; family Fabaceae) using paracetamol and carbon tetrachloride induced liver toxicity models. The dried, ground leaves of B.purpurea (40g) were soaked with 800ml...

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Main Authors: Yahya, Farhana, Mamat, Siti Syariah, Kamarolzaman, Mohammad Fauzi Fahmi, Sayeden, Altefeh Alsadat, Jakius, Krystal Fredoline, Mahmood, Nur Diyana, Shahril, Mohamad Syahmi, Darnis, Deny Susanti, Zakaria, Zainul Amiruddin
Format: Conference or Workshop Item
Language:English
Published: 2012
Subjects:
R Medicine (General)
RB Pathology
Online Access:http://irep.iium.edu.my/25374/1/P052.pdf
http://irep.iium.edu.my/25374/
http://www.mspp2012.com/
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spelling my.iium.irep.253742012-12-21T04:50:20Z http://irep.iium.edu.my/25374/ Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves Yahya, Farhana Mamat, Siti Syariah Kamarolzaman, Mohammad Fauzi Fahmi Sayeden, Altefeh Alsadat Jakius, Krystal Fredoline Mahmood, Nur Diyana Shahril, Mohamad Syahmi Darnis, Deny Susanti Zakaria, Zainul Amiruddin R Medicine (General) RB Pathology The objective of the present study was to determine the hepatoprotective activity of methanol extract of Bauhinia purpurea L. leaves (MEBP ; family Fabaceae) using paracetamol and carbon tetrachloride induced liver toxicity models. The dried, ground leaves of B.purpurea (40g) were soaked with 800ml methanol (1:20 (w/v)) for 72h at room temperature, filtered and subjected to the rotary evaporation process. This processes were repeated three times. The vehicle (10% DMSO), 200mg/kg silymarin or MEBP (50, 250 and 500 mg/kg) were administered orally once daily for 7 consecutive days in rats (n=6). Hepatotoxicity was induced by administration of CC14- (0.15 ml/kg) or PCM (3g/kg) 3 hours after the last extract administration. On the 9th day, the animals were sacrificed and the liver was collected for histopathological examination. From the histological observation, hepatic steatosis, lymphocyte infiltration and marked necrosis was observed in CC14 and PCM-treated groups (negative control). Hepatotoxic with PCM pretreated with silymarin or 500 mg/kg MEBP exhibited significant (P<0.05) decreased in he mean of histological scoring compared to the negative control. On the other hand, only 500 mg/kg MEBP significantly (P<0.05) decreased the mean of scoring for CC14-induced hepatotoxicity study compared to the negative control group (P<0.05). In conclusion, the methanol extract of leaves of Bauhinia purpurea exerts potential hepatoprotective property that warrants further investigation. 2012 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/25374/1/P052.pdf Yahya, Farhana and Mamat, Siti Syariah and Kamarolzaman, Mohammad Fauzi Fahmi and Sayeden, Altefeh Alsadat and Jakius, Krystal Fredoline and Mahmood, Nur Diyana and Shahril, Mohamad Syahmi and Darnis, Deny Susanti and Zakaria, Zainul Amiruddin (2012) Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves. In: 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology, 18th-20th May 2012, Equatorial Hotel, Penang. http://www.mspp2012.com/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RB Pathology
spellingShingle R Medicine (General)
RB Pathology
Yahya, Farhana
Mamat, Siti Syariah
Kamarolzaman, Mohammad Fauzi Fahmi
Sayeden, Altefeh Alsadat
Jakius, Krystal Fredoline
Mahmood, Nur Diyana
Shahril, Mohamad Syahmi
Darnis, Deny Susanti
Zakaria, Zainul Amiruddin
Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves
description The objective of the present study was to determine the hepatoprotective activity of methanol extract of Bauhinia purpurea L. leaves (MEBP ; family Fabaceae) using paracetamol and carbon tetrachloride induced liver toxicity models. The dried, ground leaves of B.purpurea (40g) were soaked with 800ml methanol (1:20 (w/v)) for 72h at room temperature, filtered and subjected to the rotary evaporation process. This processes were repeated three times. The vehicle (10% DMSO), 200mg/kg silymarin or MEBP (50, 250 and 500 mg/kg) were administered orally once daily for 7 consecutive days in rats (n=6). Hepatotoxicity was induced by administration of CC14- (0.15 ml/kg) or PCM (3g/kg) 3 hours after the last extract administration. On the 9th day, the animals were sacrificed and the liver was collected for histopathological examination. From the histological observation, hepatic steatosis, lymphocyte infiltration and marked necrosis was observed in CC14 and PCM-treated groups (negative control). Hepatotoxic with PCM pretreated with silymarin or 500 mg/kg MEBP exhibited significant (P<0.05) decreased in he mean of histological scoring compared to the negative control. On the other hand, only 500 mg/kg MEBP significantly (P<0.05) decreased the mean of scoring for CC14-induced hepatotoxicity study compared to the negative control group (P<0.05). In conclusion, the methanol extract of leaves of Bauhinia purpurea exerts potential hepatoprotective property that warrants further investigation.
format Conference or Workshop Item
author Yahya, Farhana
Mamat, Siti Syariah
Kamarolzaman, Mohammad Fauzi Fahmi
Sayeden, Altefeh Alsadat
Jakius, Krystal Fredoline
Mahmood, Nur Diyana
Shahril, Mohamad Syahmi
Darnis, Deny Susanti
Zakaria, Zainul Amiruddin
author_facet Yahya, Farhana
Mamat, Siti Syariah
Kamarolzaman, Mohammad Fauzi Fahmi
Sayeden, Altefeh Alsadat
Jakius, Krystal Fredoline
Mahmood, Nur Diyana
Shahril, Mohamad Syahmi
Darnis, Deny Susanti
Zakaria, Zainul Amiruddin
author_sort Yahya, Farhana
title Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves
title_short Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves
title_full Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves
title_fullStr Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves
title_full_unstemmed Hepatoprotective effects of methanol extract of Bauhinia purpurea leaves
title_sort hepatoprotective effects of methanol extract of bauhinia purpurea leaves
publishDate 2012
url http://irep.iium.edu.my/25374/1/P052.pdf
http://irep.iium.edu.my/25374/
http://www.mspp2012.com/
_version_ 1643608929909866496
score 13.211869

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