Seasonal changes effects on the serotonin and melatonin transmission
Neurotransmission of serotonin and its derivative is said to be effected by changing of season in temperate countries. The effect of photoperiod and temperature can alter the production of serotonin and melatonin in body. The depression in serotonin availability in brain leads to a depressive or...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Intellectual Consortium of Drug Discovery & Technology Development
2011
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/25344/1/CJAS.pdf http://irep.iium.edu.my/25344/ http://cpanel.canajas.ca/panel/A/1%20Atif.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Neurotransmission of serotonin and its derivative is said to be effected by changing of season in
temperate countries. The effect of photoperiod and temperature can alter the production of
serotonin and melatonin in body. The depression in serotonin availability in brain leads to a
depressive or bipolar disorder. The activity of tryptophan hydroxylase to synthesis serotonin and
monoamine oxidase (MAO) to inactivate serotonin is affected by season change. Calcitriol can
stimulate tryptophan hydroxylase to produce serotonin. CREM gene works by memorizing work
base on previous memory on how much serotonin will be produce. Melatonin it’s a serotonin
derivative act as endocrine because it produce from pineal gland and retina. Melatonin has
diurnal circadian pattern. Melatonin production is not decline by increasing in age.
Arylalkylamine N-acetyltransferase (AA-NAT) gene is one of the cAMP inducible genes is an
enzyme important in production of melatonin.
Key words: Serotonin, melotonin transmission, depression, calcitriol |
|---|