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The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.

Our previous study showed that crude extract of Pluchea Indica was able to lower blood glucose levels in hypoglycaemic test on normal rats. This study is an attempt to demonstrate whether the effect was directly related to the effect on the insulin release by the pancreatic B cell. The B cell line o...

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Main Authors: Kasmuri, Abdul Razak, Bakhtiar, M. Taher, Suriyah, Wastuti
Format: Conference or Workshop Item
Language:English
Published: 2012
Subjects:
R Medicine (General)
RB Pathology
Online Access:http://irep.iium.edu.my/25301/1/P068.pdf
http://irep.iium.edu.my/25301/
http://www.mspp2012.com/
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spelling my.iium.irep.253012014-12-09T01:12:40Z http://irep.iium.edu.my/25301/ The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line. Kasmuri, Abdul Razak Bakhtiar, M. Taher Suriyah, Wastuti R Medicine (General) RB Pathology Our previous study showed that crude extract of Pluchea Indica was able to lower blood glucose levels in hypoglycaemic test on normal rats. This study is an attempt to demonstrate whether the effect was directly related to the effect on the insulin release by the pancreatic B cell. The B cell line of RIN5f of rats insulinamo were used in studying the insulin-releasing effect of sequential extractions of Pluchea Indica. The solvents used in the extraction were in the sequence of hexane, dichloromethane, ethyl acetate and methanol. Beside the sequential extractions there was a water extract of the plant. An antidiabetic drug, glibenclamide, which is known to stimulate B cells to produce insulin, was used as the positive control. The results showed that glibenclamide-treated, hexane, dichloromethane and water extract-treated groups were significantly increased the insulin release (p<0.01 and p<0.05 for all extract-treated groups). Thus the study showed that the model was able to demonstrate the stimulating effect of glibenclamide and show the effect of the plant extracts on B cells. 2012 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/25301/1/P068.pdf Kasmuri, Abdul Razak and Bakhtiar, M. Taher and Suriyah, Wastuti (2012) The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line. In: 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology, 18-20 may 2012, Equatorial Hotel, Penang. http://www.mspp2012.com/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RB Pathology
spellingShingle R Medicine (General)
RB Pathology
Kasmuri, Abdul Razak
Bakhtiar, M. Taher
Suriyah, Wastuti
The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
description Our previous study showed that crude extract of Pluchea Indica was able to lower blood glucose levels in hypoglycaemic test on normal rats. This study is an attempt to demonstrate whether the effect was directly related to the effect on the insulin release by the pancreatic B cell. The B cell line of RIN5f of rats insulinamo were used in studying the insulin-releasing effect of sequential extractions of Pluchea Indica. The solvents used in the extraction were in the sequence of hexane, dichloromethane, ethyl acetate and methanol. Beside the sequential extractions there was a water extract of the plant. An antidiabetic drug, glibenclamide, which is known to stimulate B cells to produce insulin, was used as the positive control. The results showed that glibenclamide-treated, hexane, dichloromethane and water extract-treated groups were significantly increased the insulin release (p<0.01 and p<0.05 for all extract-treated groups). Thus the study showed that the model was able to demonstrate the stimulating effect of glibenclamide and show the effect of the plant extracts on B cells.
format Conference or Workshop Item
author Kasmuri, Abdul Razak
Bakhtiar, M. Taher
Suriyah, Wastuti
author_facet Kasmuri, Abdul Razak
Bakhtiar, M. Taher
Suriyah, Wastuti
author_sort Kasmuri, Abdul Razak
title The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_short The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_full The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_fullStr The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_full_unstemmed The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_sort effect of pluchea indica (l) (beluntas) extracts on the insulin release of rin5f cell line.
publishDate 2012
url http://irep.iium.edu.my/25301/1/P068.pdf
http://irep.iium.edu.my/25301/
http://www.mspp2012.com/
_version_ 1643608912222486528
score 13.211869

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