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Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)

The bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca) leaves obtained by using supercritical carbon dioxide (SC-CO2) extraction were investigated and the obtained crude extract yields were compared in order to select the best operation parameters. Since carbon dioxide is a non-pol...

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Main Authors: Md. Salleh, Liza, Abdul Rahman, Russly, Bimakr, Mandana, Selamat, Jinap, A., Rahmat, Sarker, Md. Zaidul Islam, Abdul Hamid, Azizah
Format: Article
Language:English
Published: Elsevier 2010
Subjects:
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/18308/1/liza.pdf
http://irep.iium.edu.my/18308/
http://www.sciencedirect.com/science/article/pii/S0960308509000169
http://dx.doi.org/10.1016/j.fbp.2009.02.001
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spelling my.iium.irep.183082012-03-19T06:37:01Z http://irep.iium.edu.my/18308/ Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca) Md. Salleh, Liza Abdul Rahman, Russly Bimakr, Mandana Selamat, Jinap A., Rahmat Sarker, Md. Zaidul Islam Abdul Hamid, Azizah RM Therapeutics. Pharmacology RS Pharmacy and materia medica The bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca) leaves obtained by using supercritical carbon dioxide (SC-CO2) extraction were investigated and the obtained crude extract yields were compared in order to select the best operation parameters. Since carbon dioxide is a non-polar solvent, ethanolwas used as co-solvent to increase the polarity of the fluid. The studied parameters were pressure (100, 150 and 200 bar), temperature (40, 50 and 60 ◦C) and dynamic extraction time (40, 60 and 80 min). The optimum extraction condition occurred at 200 bar, 50 ◦C and 60 min. Based on the mean value, pressure had dominant effect on the extraction yield. Apart from the optimum SFE conditions two other conditions namely at minimum (100 bar, 40 ◦C, 40 min) and maximum (200 bar, 60 ◦C, 80 min) levels of each studied parameters as control runs were analyzed by HPLC to determine the major bioactive flavonoid compounds from S. crispus. Under the optimum conditions eight flavonoid compounds were identified; they were (+)-catechin, (−)-epicatechin, rutin, myricetin, luteolin, apigenin, naringenin and kaempferol. © 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. Keywords: Strobilanthes crispus; Bioactive flavonoid; Supercritical carbon dioxide extraction; HPLC Elsevier 2010 Article REM application/pdf en http://irep.iium.edu.my/18308/1/liza.pdf Md. Salleh, Liza and Abdul Rahman, Russly and Bimakr, Mandana and Selamat, Jinap and A., Rahmat and Sarker, Md. Zaidul Islam and Abdul Hamid, Azizah (2010) Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca). Food and Bioproducts Processing, 88 (2-3). pp. 319-326. ISSN 0960-3085 http://www.sciencedirect.com/science/article/pii/S0960308509000169 http://dx.doi.org/10.1016/j.fbp.2009.02.001
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Md. Salleh, Liza
Abdul Rahman, Russly
Bimakr, Mandana
Selamat, Jinap
A., Rahmat
Sarker, Md. Zaidul Islam
Abdul Hamid, Azizah
Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
description The bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca) leaves obtained by using supercritical carbon dioxide (SC-CO2) extraction were investigated and the obtained crude extract yields were compared in order to select the best operation parameters. Since carbon dioxide is a non-polar solvent, ethanolwas used as co-solvent to increase the polarity of the fluid. The studied parameters were pressure (100, 150 and 200 bar), temperature (40, 50 and 60 ◦C) and dynamic extraction time (40, 60 and 80 min). The optimum extraction condition occurred at 200 bar, 50 ◦C and 60 min. Based on the mean value, pressure had dominant effect on the extraction yield. Apart from the optimum SFE conditions two other conditions namely at minimum (100 bar, 40 ◦C, 40 min) and maximum (200 bar, 60 ◦C, 80 min) levels of each studied parameters as control runs were analyzed by HPLC to determine the major bioactive flavonoid compounds from S. crispus. Under the optimum conditions eight flavonoid compounds were identified; they were (+)-catechin, (−)-epicatechin, rutin, myricetin, luteolin, apigenin, naringenin and kaempferol. © 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. Keywords: Strobilanthes crispus; Bioactive flavonoid; Supercritical carbon dioxide extraction; HPLC
format Article
author Md. Salleh, Liza
Abdul Rahman, Russly
Bimakr, Mandana
Selamat, Jinap
A., Rahmat
Sarker, Md. Zaidul Islam
Abdul Hamid, Azizah
author_facet Md. Salleh, Liza
Abdul Rahman, Russly
Bimakr, Mandana
Selamat, Jinap
A., Rahmat
Sarker, Md. Zaidul Islam
Abdul Hamid, Azizah
author_sort Md. Salleh, Liza
title Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_short Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_full Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_fullStr Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_full_unstemmed Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_sort supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (pecah kaca)
publisher Elsevier
publishDate 2010
url http://irep.iium.edu.my/18308/1/liza.pdf
http://irep.iium.edu.my/18308/
http://www.sciencedirect.com/science/article/pii/S0960308509000169
http://dx.doi.org/10.1016/j.fbp.2009.02.001
_version_ 1643607437794607104
score 13.211869

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