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Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology

The bioactive flavonoid compounds of spearmint (Mentha spicata L.) leaves were obtained by using supercritical carbon dioxide (SC-CO2) extraction. Extraction was carried out according to face-centred central composite design, and independent variables were pressure (100, 200 and 300 bar), temperatur...

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Main Authors: Bimakr, Mandana, Abdul Rahman, Russly, Ganjloo, Ali, Taip, Farah Saleena, Md Salleh, Liza, Sarker, Md. Zaidul Islam
Format: Article
Language:English
English
Published: Springer 2012
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/17932/1/Mandana.htm
http://irep.iium.edu.my/17932/3/Optimization_of_Supercritical_Carbon_Dioxide_Extraction_of_Bioactive_Flavonoid_Compounds_from_Spearmint_%28Mentha_spicata_L.%29_Leaves_by_Using_Response_Surface_Methodology.pdf
http://irep.iium.edu.my/17932/
http://www.springer.com/food+science/journal/11947
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spelling my.iium.irep.179322016-12-15T07:13:55Z http://irep.iium.edu.my/17932/ Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology Bimakr, Mandana Abdul Rahman, Russly Ganjloo, Ali Taip, Farah Saleena Md Salleh, Liza Sarker, Md. Zaidul Islam QD Chemistry The bioactive flavonoid compounds of spearmint (Mentha spicata L.) leaves were obtained by using supercritical carbon dioxide (SC-CO2) extraction. Extraction was carried out according to face-centred central composite design, and independent variables were pressure (100, 200 and 300 bar), temperature (40, 50 and 60 °C) and co-solvent amount (3, 6 and 9 g/min). The extraction process was optimized by using response surface methodology for the highest crude extraction yield of bioactive flavonoid compounds. The optimal conditions were identified as 209.39 bar pressure, 50.00 °C temperature and 7.39 g/min co-solvent amount. The obtained extract under optimum SC-CO2 condition was analysed by high-performance liquid chromatography. Seven bioactive flavonoids including catechin, epicatechin, rutin, luteolin, myricetin, apigenin and naringenin were identified as major compounds. The results of quantification showed that spearmint leaves are potential source of antioxidant compounds. Springer 2012-04-29 Article REM application/pdf en http://irep.iium.edu.my/17932/1/Mandana.htm application/pdf en http://irep.iium.edu.my/17932/3/Optimization_of_Supercritical_Carbon_Dioxide_Extraction_of_Bioactive_Flavonoid_Compounds_from_Spearmint_%28Mentha_spicata_L.%29_Leaves_by_Using_Response_Surface_Methodology.pdf Bimakr, Mandana and Abdul Rahman, Russly and Ganjloo, Ali and Taip, Farah Saleena and Md Salleh, Liza and Sarker, Md. Zaidul Islam (2012) Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology. Food and Bioprocess Technology, 5 (3). pp. 912-920. ISSN 1935-5130 http://www.springer.com/food+science/journal/11947 DOI:10.1007/s11947-010-0504-4
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QD Chemistry
spellingShingle QD Chemistry
Bimakr, Mandana
Abdul Rahman, Russly
Ganjloo, Ali
Taip, Farah Saleena
Md Salleh, Liza
Sarker, Md. Zaidul Islam
Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology
description The bioactive flavonoid compounds of spearmint (Mentha spicata L.) leaves were obtained by using supercritical carbon dioxide (SC-CO2) extraction. Extraction was carried out according to face-centred central composite design, and independent variables were pressure (100, 200 and 300 bar), temperature (40, 50 and 60 °C) and co-solvent amount (3, 6 and 9 g/min). The extraction process was optimized by using response surface methodology for the highest crude extraction yield of bioactive flavonoid compounds. The optimal conditions were identified as 209.39 bar pressure, 50.00 °C temperature and 7.39 g/min co-solvent amount. The obtained extract under optimum SC-CO2 condition was analysed by high-performance liquid chromatography. Seven bioactive flavonoids including catechin, epicatechin, rutin, luteolin, myricetin, apigenin and naringenin were identified as major compounds. The results of quantification showed that spearmint leaves are potential source of antioxidant compounds.
format Article
author Bimakr, Mandana
Abdul Rahman, Russly
Ganjloo, Ali
Taip, Farah Saleena
Md Salleh, Liza
Sarker, Md. Zaidul Islam
author_facet Bimakr, Mandana
Abdul Rahman, Russly
Ganjloo, Ali
Taip, Farah Saleena
Md Salleh, Liza
Sarker, Md. Zaidul Islam
author_sort Bimakr, Mandana
title Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology
title_short Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology
title_full Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology
title_fullStr Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology
title_full_unstemmed Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology
title_sort optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (mentha spicata l.) leaves by using response surface methodology
publisher Springer
publishDate 2012
url http://irep.iium.edu.my/17932/1/Mandana.htm
http://irep.iium.edu.my/17932/3/Optimization_of_Supercritical_Carbon_Dioxide_Extraction_of_Bioactive_Flavonoid_Compounds_from_Spearmint_%28Mentha_spicata_L.%29_Leaves_by_Using_Response_Surface_Methodology.pdf
http://irep.iium.edu.my/17932/
http://www.springer.com/food+science/journal/11947
_version_ 1643607381732491264
score 13.211869

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