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Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats

Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteri...

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Main Authors: Saxena, Anil Kumar, Abdul Majeed, Saif Saad, Oothuman, Pakeer, Gurtu, Sunil
Format: Conference or Workshop Item
Language:English
Published: 2011
Subjects:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:http://irep.iium.edu.my/13710/1/MSPP_25th.pdf
http://irep.iium.edu.my/13710/
http://www.anilkumar@iium.edu.com.my
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spelling my.iium.irep.137102012-03-14T03:09:55Z http://irep.iium.edu.my/13710/ Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Gurtu, Sunil RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders. The present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occur in response to increased oxidative stress following ischemic insult. 2011-05 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/13710/1/MSPP_25th.pdf Saxena, Anil Kumar and Abdul Majeed, Saif Saad and Oothuman, Pakeer and Gurtu, Sunil (2011) Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats. In: "Advances in drug development for a better well-being", 25th-26th May 2011, Faculty of Medicine and Health Sciences, UPM, Kuala Lumpur. http://www.anilkumar@iium.edu.com.my
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Saxena, Anil Kumar
Abdul Majeed, Saif Saad
Oothuman, Pakeer
Gurtu, Sunil
Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
description Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders. The present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occur in response to increased oxidative stress following ischemic insult.
format Conference or Workshop Item
author Saxena, Anil Kumar
Abdul Majeed, Saif Saad
Oothuman, Pakeer
Gurtu, Sunil
author_facet Saxena, Anil Kumar
Abdul Majeed, Saif Saad
Oothuman, Pakeer
Gurtu, Sunil
author_sort Saxena, Anil Kumar
title Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_short Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_full Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_fullStr Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_full_unstemmed Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_sort assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
publishDate 2011
url http://irep.iium.edu.my/13710/1/MSPP_25th.pdf
http://irep.iium.edu.my/13710/
http://www.anilkumar@iium.edu.com.my
_version_ 1643606791583432704
score 13.211869

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