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Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma

CDCP1, a transmembrane protein with intracellular tyrosine residues which are phosphorylated upon activation, is supposed to be engaged in proliferative activities and resistance to apoptosis of cancer cells. High level of CDCP1 expression proved to be a poor prognosticator for lung adenocarcinoma....

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Main Authors: Mamat, Suhana, Ikeda, Jun-Ichiro, Enomoto, Takayuki, Ueda, Yutaka, ., Nur Rahadiani, Tian, Tian, Yi, Wang, Ying, Qiu, Kimura, Tadashi, Aozasa, Katsuyuki, Morii, Eiichi
Format: Article
Language:English
Published: Spandidos Publications Ltd. 2010
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/12093/1/prognostic_significance_of_CUB_domain_containing.pdf
http://irep.iium.edu.my/12093/
http://www.spandidos-publications.com/or/23/5/1221
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spelling my.iium.irep.120932012-07-20T01:56:50Z http://irep.iium.edu.my/12093/ Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma Mamat, Suhana Ikeda, Jun-Ichiro Enomoto, Takayuki Ueda, Yutaka ., Nur Rahadiani Tian, Tian Yi, Wang Ying, Qiu Kimura, Tadashi Aozasa, Katsuyuki Morii, Eiichi QD Chemistry CDCP1, a transmembrane protein with intracellular tyrosine residues which are phosphorylated upon activation, is supposed to be engaged in proliferative activities and resistance to apoptosis of cancer cells. High level of CDCP1 expression proved to be a poor prognosticator for lung adenocarcinoma. Here, expression level of CDCP1 was immunohistochemically examined in 110 cases (median age of 54.7 years) of endometrioid adenocarcinoma, and its clinical implications were evaluated. Tumor stage was stage I in 71 cases (64.5%), II in 5 (4.5%), III in 28 (25.5%), and IV in 6 (5.5%). Staining intensity of tumor cells was divided into two categories; tumor cells with no to weak and moderate to strong membrane staining. The intensity of CDCP1 expression in each case was defined by the staining of major population of cells as follows; cases with tumor cells showing no to weak and moderate to high membrane staining were categorized as CDCP1-low and CDCP1-high, respectively. Eighty-seven of 110 cases were categorized as CDCP1-high, and the remaining as CDCP1-low. Significant positive correlation was observed between low CDCP1 expression and stage (p=0.0091), relapse rate (p=0.0017), and poor prognosis (p=0.0009). Multivariate analysis revealed that low CDCP1 and advanced stage were independent poor prognostic factors for both OS and DFS. As compared to cancer cells, normal endometrium continuously expressed CDCP1. These suggested that the attitude of CDCP1 in cancers of lung and endometrium was different. Different role of CDCP1 by tissues and cancers is discussed. Spandidos Publications Ltd. 2010-05 Article REM application/pdf en http://irep.iium.edu.my/12093/1/prognostic_significance_of_CUB_domain_containing.pdf Mamat, Suhana and Ikeda, Jun-Ichiro and Enomoto, Takayuki and Ueda, Yutaka and ., Nur Rahadiani and Tian, Tian and Yi, Wang and Ying, Qiu and Kimura, Tadashi and Aozasa, Katsuyuki and Morii, Eiichi (2010) Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma. Onconology Reports , 23 (5). pp. 1221-1227. ISSN 1791-2431 (O), 1021-335X (P) http://www.spandidos-publications.com/or/23/5/1221 10.3892/or_00000753
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Mamat, Suhana
Ikeda, Jun-Ichiro
Enomoto, Takayuki
Ueda, Yutaka
., Nur Rahadiani
Tian, Tian
Yi, Wang
Ying, Qiu
Kimura, Tadashi
Aozasa, Katsuyuki
Morii, Eiichi
Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
description CDCP1, a transmembrane protein with intracellular tyrosine residues which are phosphorylated upon activation, is supposed to be engaged in proliferative activities and resistance to apoptosis of cancer cells. High level of CDCP1 expression proved to be a poor prognosticator for lung adenocarcinoma. Here, expression level of CDCP1 was immunohistochemically examined in 110 cases (median age of 54.7 years) of endometrioid adenocarcinoma, and its clinical implications were evaluated. Tumor stage was stage I in 71 cases (64.5%), II in 5 (4.5%), III in 28 (25.5%), and IV in 6 (5.5%). Staining intensity of tumor cells was divided into two categories; tumor cells with no to weak and moderate to strong membrane staining. The intensity of CDCP1 expression in each case was defined by the staining of major population of cells as follows; cases with tumor cells showing no to weak and moderate to high membrane staining were categorized as CDCP1-low and CDCP1-high, respectively. Eighty-seven of 110 cases were categorized as CDCP1-high, and the remaining as CDCP1-low. Significant positive correlation was observed between low CDCP1 expression and stage (p=0.0091), relapse rate (p=0.0017), and poor prognosis (p=0.0009). Multivariate analysis revealed that low CDCP1 and advanced stage were independent poor prognostic factors for both OS and DFS. As compared to cancer cells, normal endometrium continuously expressed CDCP1. These suggested that the attitude of CDCP1 in cancers of lung and endometrium was different. Different role of CDCP1 by tissues and cancers is discussed.
format Article
author Mamat, Suhana
Ikeda, Jun-Ichiro
Enomoto, Takayuki
Ueda, Yutaka
., Nur Rahadiani
Tian, Tian
Yi, Wang
Ying, Qiu
Kimura, Tadashi
Aozasa, Katsuyuki
Morii, Eiichi
author_facet Mamat, Suhana
Ikeda, Jun-Ichiro
Enomoto, Takayuki
Ueda, Yutaka
., Nur Rahadiani
Tian, Tian
Yi, Wang
Ying, Qiu
Kimura, Tadashi
Aozasa, Katsuyuki
Morii, Eiichi
author_sort Mamat, Suhana
title Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
title_short Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
title_full Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
title_fullStr Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
title_full_unstemmed Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
title_sort prognostic significance of cub domain containing protein expression in endometrioid adenocarcinoma
publisher Spandidos Publications Ltd.
publishDate 2010
url http://irep.iium.edu.my/12093/1/prognostic_significance_of_CUB_domain_containing.pdf
http://irep.iium.edu.my/12093/
http://www.spandidos-publications.com/or/23/5/1221
_version_ 1643606574688632832
score 13.211869

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