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Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis

Introduction: The purpose of this systematic review and meta-analysis was to determine the potential benefits of probiotics in the treatment of atopic dermatitis (AD) in adults. Materials and methods: A meta-analysis was per-formed on randomized controlled trials investigating the use of probiotics,...

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Main Authors: Nawawi, Muhammad Hariadi, Arzmi, Mohd Hafiz, Azmi, Afiza, Azizudin, Maryam Al-Batul
Format: Article
Language:English
Published: Universiti Putra Malaysia 2025
Subjects:
QR Microbiology
RK Dentistry
Online Access:http://irep.iium.edu.my/120704/7/120704_Evaluating%20the%20efficacy%20of%20probiotics.pdf
http://irep.iium.edu.my/120704/
https://medic.upm.edu.my/our_journal/volume_21_2025/mjmhs_vol21_no_2_march_2025-85558
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spelling my.iium.irep.1207042025-04-25T03:05:57Z http://irep.iium.edu.my/120704/ Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis Nawawi, Muhammad Hariadi Arzmi, Mohd Hafiz Azmi, Afiza Azizudin, Maryam Al-Batul QR Microbiology RK Dentistry Introduction: The purpose of this systematic review and meta-analysis was to determine the potential benefits of probiotics in the treatment of atopic dermatitis (AD) in adults. Materials and methods: A meta-analysis was per-formed on randomized controlled trials investigating the use of probiotics, either applied to the skin or taken orally, to decrease AD severity in adult patients. A comprehensive search gathered all available trials from January 1st, 2012 until November 1st, 2023. The analysis was carried out using Review Manager 5 software. Results: In a study involving 10 prevention studies with 457 adult participants, probiotics significantly reduced AD severity compared to the control group, as indicated by SCORAD scores (MD: -7.92; 95% CI -11.69 to -4.15; p < 0.0001). Both short-term and long-term treatments showed significant reductions in SCORAD scores. Single-strain and mixed-strain probiotics were both effective. Probiotics improved SCORAD scores for both young and middle-aged adults. Internal (oral) and external (topical) interventions both significantly reduced AD severity. Probiotics had a significant impact on SCORAD scores in both Europe and Asia. The effectiveness of probiotics was consistent regardless of treatment duration, type of probiotics used (single-strain probiotics vs. mixed-strain probiotics), participant age, intervention type, or geographical area. Conclusion: Probiotics significantly alleviate allergic symptoms in adults with AD, demonstrating consistent effectiveness across various factors including treatment duration, type of probiotics, participant age, intervention type, and geographical area. Universiti Putra Malaysia 2025-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/120704/7/120704_Evaluating%20the%20efficacy%20of%20probiotics.pdf Nawawi, Muhammad Hariadi and Arzmi, Mohd Hafiz and Azmi, Afiza and Azizudin, Maryam Al-Batul (2025) Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis. Malaysian Journal of Medicine and Health Sciences, 21 (2). pp. 216-226. ISSN 1675-8544 E-ISSN 2636-9346 https://medic.upm.edu.my/our_journal/volume_21_2025/mjmhs_vol21_no_2_march_2025-85558 10.47836/mjmhs.21.1.27
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QR Microbiology
RK Dentistry
spellingShingle QR Microbiology
RK Dentistry
Nawawi, Muhammad Hariadi
Arzmi, Mohd Hafiz
Azmi, Afiza
Azizudin, Maryam Al-Batul
Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis
description Introduction: The purpose of this systematic review and meta-analysis was to determine the potential benefits of probiotics in the treatment of atopic dermatitis (AD) in adults. Materials and methods: A meta-analysis was per-formed on randomized controlled trials investigating the use of probiotics, either applied to the skin or taken orally, to decrease AD severity in adult patients. A comprehensive search gathered all available trials from January 1st, 2012 until November 1st, 2023. The analysis was carried out using Review Manager 5 software. Results: In a study involving 10 prevention studies with 457 adult participants, probiotics significantly reduced AD severity compared to the control group, as indicated by SCORAD scores (MD: -7.92; 95% CI -11.69 to -4.15; p < 0.0001). Both short-term and long-term treatments showed significant reductions in SCORAD scores. Single-strain and mixed-strain probiotics were both effective. Probiotics improved SCORAD scores for both young and middle-aged adults. Internal (oral) and external (topical) interventions both significantly reduced AD severity. Probiotics had a significant impact on SCORAD scores in both Europe and Asia. The effectiveness of probiotics was consistent regardless of treatment duration, type of probiotics used (single-strain probiotics vs. mixed-strain probiotics), participant age, intervention type, or geographical area. Conclusion: Probiotics significantly alleviate allergic symptoms in adults with AD, demonstrating consistent effectiveness across various factors including treatment duration, type of probiotics, participant age, intervention type, and geographical area.
format Article
author Nawawi, Muhammad Hariadi
Arzmi, Mohd Hafiz
Azmi, Afiza
Azizudin, Maryam Al-Batul
author_facet Nawawi, Muhammad Hariadi
Arzmi, Mohd Hafiz
Azmi, Afiza
Azizudin, Maryam Al-Batul
author_sort Nawawi, Muhammad Hariadi
title Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis
title_short Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis
title_full Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis
title_fullStr Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis
title_full_unstemmed Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis
title_sort evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis
publisher Universiti Putra Malaysia
publishDate 2025
url http://irep.iium.edu.my/120704/7/120704_Evaluating%20the%20efficacy%20of%20probiotics.pdf
http://irep.iium.edu.my/120704/
https://medic.upm.edu.my/our_journal/volume_21_2025/mjmhs_vol21_no_2_march_2025-85558
_version_ 1830795148240355328
score 13.252575

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