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Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model

INTRODUCTION: The International Diabetes Federation (IDF) reported 463 million global cases of Type 2 diabetes mellitus (T2DM) in 2019. Lepidium meyenii (maca) and marine collagen peptide (MCP) have individually shown potential in alleviating T2DM symptoms, but their combined effects remain underexp...

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Main Authors: Othman, Najwa Hanim, Ismawi, Hidayatul Radziah, Mohd Zainudin, Maizura, Abd. Fuaat, Azliana
Format: Article
Language:English
Published: 2025
Subjects:
RC627 Specialties of Internal Medicine-Metabolic Diseases
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/117992/7/117992_Antidiabetic%20Effects%20of%20Coffee.pdf
http://irep.iium.edu.my/117992/
https://journals.iium.edu.my/kom
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spelling my.iium.irep.1179922025-01-10T01:38:29Z http://irep.iium.edu.my/117992/ Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model Othman, Najwa Hanim Ismawi, Hidayatul Radziah Mohd Zainudin, Maizura Abd. Fuaat, Azliana RC627 Specialties of Internal Medicine-Metabolic Diseases RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System RM Therapeutics. Pharmacology INTRODUCTION: The International Diabetes Federation (IDF) reported 463 million global cases of Type 2 diabetes mellitus (T2DM) in 2019. Lepidium meyenii (maca) and marine collagen peptide (MCP) have individually shown potential in alleviating T2DM symptoms, but their combined effects remain underexplored. This study evaluated the impact of Blackbelt® coffee, enriched with maca and MCP, on fasting blood glucose, insulin levels, and pancreatic and liver histology in a T2DM rat model. MATERIALS AND METHODS: Thirty-six male rats with a high-fat diet and streptozotocin-induced diabetes were treated with metformin, maca, MCP, Maca/MCP® (Blackbelt® formulation), or Blackbelt® coffee for 28 days. Fasting blood glucose (FBG) levels were monitored, and fasting serum insulin, HOMA-IR (insulin resistance), HOMA-B (ß-cell function), and QUICKI (insulin sensitivity) were assessed. Histological analysis of the pancreas and liver was performed using haematoxylin-eosin staining. RESULTS: After 4 weeks, treatments significantly reduced FBG levels compared to control (p<0.05), with Blackbelt® coffee notably increasing insulin production (p<0.05). All groups showed decreased HOMA-IR (p<0.05), and both metformin and Blackbelt® coffee groups had significant HOMA-B score increases (p<0.05). Histological analysis revealed improved pancreatic health in all treated groups, with significant liver histology enhancement in the Blackbelt® coffee group. CONCLUSIONS: Blackbelt® coffee improved FBG levels, insulin resistance, and ß-cell function more effectively than maca or MCP alone, and surpassed metformin in insulin production and hepatoprotective effects. Despite its promising potential for diabetes therapy, further research is needed to understand the synergistic effects of maca and MCP and the contribution of the coffee components. 2025-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/117992/7/117992_Antidiabetic%20Effects%20of%20Coffee.pdf Othman, Najwa Hanim and Ismawi, Hidayatul Radziah and Mohd Zainudin, Maizura and Abd. Fuaat, Azliana (2025) Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model. IIUM Medical Journal Malaysia, 24 (1). pp. 94-104. ISSN 1823-4631 E-ISSN 2735-2285 https://journals.iium.edu.my/kom
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC627 Specialties of Internal Medicine-Metabolic Diseases
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
RM Therapeutics. Pharmacology
spellingShingle RC627 Specialties of Internal Medicine-Metabolic Diseases
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
RM Therapeutics. Pharmacology
Othman, Najwa Hanim
Ismawi, Hidayatul Radziah
Mohd Zainudin, Maizura
Abd. Fuaat, Azliana
Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model
description INTRODUCTION: The International Diabetes Federation (IDF) reported 463 million global cases of Type 2 diabetes mellitus (T2DM) in 2019. Lepidium meyenii (maca) and marine collagen peptide (MCP) have individually shown potential in alleviating T2DM symptoms, but their combined effects remain underexplored. This study evaluated the impact of Blackbelt® coffee, enriched with maca and MCP, on fasting blood glucose, insulin levels, and pancreatic and liver histology in a T2DM rat model. MATERIALS AND METHODS: Thirty-six male rats with a high-fat diet and streptozotocin-induced diabetes were treated with metformin, maca, MCP, Maca/MCP® (Blackbelt® formulation), or Blackbelt® coffee for 28 days. Fasting blood glucose (FBG) levels were monitored, and fasting serum insulin, HOMA-IR (insulin resistance), HOMA-B (ß-cell function), and QUICKI (insulin sensitivity) were assessed. Histological analysis of the pancreas and liver was performed using haematoxylin-eosin staining. RESULTS: After 4 weeks, treatments significantly reduced FBG levels compared to control (p<0.05), with Blackbelt® coffee notably increasing insulin production (p<0.05). All groups showed decreased HOMA-IR (p<0.05), and both metformin and Blackbelt® coffee groups had significant HOMA-B score increases (p<0.05). Histological analysis revealed improved pancreatic health in all treated groups, with significant liver histology enhancement in the Blackbelt® coffee group. CONCLUSIONS: Blackbelt® coffee improved FBG levels, insulin resistance, and ß-cell function more effectively than maca or MCP alone, and surpassed metformin in insulin production and hepatoprotective effects. Despite its promising potential for diabetes therapy, further research is needed to understand the synergistic effects of maca and MCP and the contribution of the coffee components.
format Article
author Othman, Najwa Hanim
Ismawi, Hidayatul Radziah
Mohd Zainudin, Maizura
Abd. Fuaat, Azliana
author_facet Othman, Najwa Hanim
Ismawi, Hidayatul Radziah
Mohd Zainudin, Maizura
Abd. Fuaat, Azliana
author_sort Othman, Najwa Hanim
title Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model
title_short Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model
title_full Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model
title_fullStr Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model
title_full_unstemmed Antidiabetic effects of coffee enriched with maca and marine collagen peptide (Blackbelt®) in a Type 2 diabetes mellitus rat model
title_sort antidiabetic effects of coffee enriched with maca and marine collagen peptide (blackbelt®) in a type 2 diabetes mellitus rat model
publishDate 2025
url http://irep.iium.edu.my/117992/7/117992_Antidiabetic%20Effects%20of%20Coffee.pdf
http://irep.iium.edu.my/117992/
https://journals.iium.edu.my/kom
_version_ 1821105173874868224
score 13.244413

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