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The prognostic power of blood biomarkers in ischemic stroke: a systematic review

Background: Blood biomarkers have emerged as potential indicators of poor outcomes following ischemic stroke, helping to monitor the onset of stroke-related processes. Identifying reliable and accessible biomarkers for assessing the prognosis of ischemic stroke patients remains a significant clinica...

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Main Authors: Che Husin, Nur Ain Assila Husna, Kaderi, Mohd Arifin, Mat Nor, Mohd Basri, Zainuddin, Norafiza
Format: Article
Language:English
Published: IIUM Press 2024
Subjects:
QH426 Genetics
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Online Access:http://irep.iium.edu.my/117465/9/117465_The%20prognostic%20power%20of%20blood%20biomarkers%20in%20ischemic%20stroke.pdf
http://irep.iium.edu.my/117465/
https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/941/862
https://doi.org/10.31436/ijahs.v8i5
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spelling my.iium.irep.1174652025-01-06T09:29:16Z http://irep.iium.edu.my/117465/ The prognostic power of blood biomarkers in ischemic stroke: a systematic review Che Husin, Nur Ain Assila Husna Kaderi, Mohd Arifin Mat Nor, Mohd Basri Zainuddin, Norafiza QH426 Genetics RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Background: Blood biomarkers have emerged as potential indicators of poor outcomes following ischemic stroke, helping to monitor the onset of stroke-related processes. Identifying reliable and accessible biomarkers for assessing the prognosis of ischemic stroke patients remains a significant clinical challenge. One of the most difficult areas of research in cerebrovascular disease is the discovery and validation of dependable biomarkers to track the clinical progression of ischemic stroke and predict patient outcomes. Therefore, this article aims to systematically compile evidence on blood-based biomarkers for ischemic stroke prognosis and their clinical outcomes. Methods: Three electronic search engines PubMed, Scopus and Cochrane Library used to search for articles related to the study by following PRISMA-P guidelines using specific keywords covering from January 2018 to December 2023. Seventeen studies were selected from 545 articles based on specific inclusion and exclusion criteria, and their quality was assessed using the Crowe Critical Appraisal Tool (CCAT). Results: A total of 545 articles were screened and 17 full-text articles were evaluated. The pathophysiological mechanism(s) involved in ischemic stroke are inflammation marker, angiogenesis marker, oxidative stress marker, neurofilament light chain marker and glial fibrillary acidic protein marker. The clinical outcomes of the biomarkers for ischemic stroke prognosis depend much on the performance of diagnostic accuracy. The study also highlights the importance of the timing of biomarker measurements post-event such as within 24 hours after stroke which is crucial for accurate prognosis. The clinical factors also contribute to the progress of prognostication of ischemic stroke such as age, medical history, particularly hypertension and diabetes which could impact stroke outcomes. Conclusion: Blood biomarkers alongside clinical factors, offer valuable insights into ischemic stroke outcomes. This review emphasizes their potential to improve stroke prognosis and management. IIUM Press 2024-12-27 Article PeerReviewed application/pdf en http://irep.iium.edu.my/117465/9/117465_The%20prognostic%20power%20of%20blood%20biomarkers%20in%20ischemic%20stroke.pdf Che Husin, Nur Ain Assila Husna and Kaderi, Mohd Arifin and Mat Nor, Mohd Basri and Zainuddin, Norafiza (2024) The prognostic power of blood biomarkers in ischemic stroke: a systematic review. International Journal of Allied Health Sciences, 8 (5). pp. 350-358. E-ISSN 2600-8491 https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/941/862 https://doi.org/10.31436/ijahs.v8i5
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QH426 Genetics
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
spellingShingle QH426 Genetics
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Che Husin, Nur Ain Assila Husna
Kaderi, Mohd Arifin
Mat Nor, Mohd Basri
Zainuddin, Norafiza
The prognostic power of blood biomarkers in ischemic stroke: a systematic review
description Background: Blood biomarkers have emerged as potential indicators of poor outcomes following ischemic stroke, helping to monitor the onset of stroke-related processes. Identifying reliable and accessible biomarkers for assessing the prognosis of ischemic stroke patients remains a significant clinical challenge. One of the most difficult areas of research in cerebrovascular disease is the discovery and validation of dependable biomarkers to track the clinical progression of ischemic stroke and predict patient outcomes. Therefore, this article aims to systematically compile evidence on blood-based biomarkers for ischemic stroke prognosis and their clinical outcomes. Methods: Three electronic search engines PubMed, Scopus and Cochrane Library used to search for articles related to the study by following PRISMA-P guidelines using specific keywords covering from January 2018 to December 2023. Seventeen studies were selected from 545 articles based on specific inclusion and exclusion criteria, and their quality was assessed using the Crowe Critical Appraisal Tool (CCAT). Results: A total of 545 articles were screened and 17 full-text articles were evaluated. The pathophysiological mechanism(s) involved in ischemic stroke are inflammation marker, angiogenesis marker, oxidative stress marker, neurofilament light chain marker and glial fibrillary acidic protein marker. The clinical outcomes of the biomarkers for ischemic stroke prognosis depend much on the performance of diagnostic accuracy. The study also highlights the importance of the timing of biomarker measurements post-event such as within 24 hours after stroke which is crucial for accurate prognosis. The clinical factors also contribute to the progress of prognostication of ischemic stroke such as age, medical history, particularly hypertension and diabetes which could impact stroke outcomes. Conclusion: Blood biomarkers alongside clinical factors, offer valuable insights into ischemic stroke outcomes. This review emphasizes their potential to improve stroke prognosis and management.
format Article
author Che Husin, Nur Ain Assila Husna
Kaderi, Mohd Arifin
Mat Nor, Mohd Basri
Zainuddin, Norafiza
author_facet Che Husin, Nur Ain Assila Husna
Kaderi, Mohd Arifin
Mat Nor, Mohd Basri
Zainuddin, Norafiza
author_sort Che Husin, Nur Ain Assila Husna
title The prognostic power of blood biomarkers in ischemic stroke: a systematic review
title_short The prognostic power of blood biomarkers in ischemic stroke: a systematic review
title_full The prognostic power of blood biomarkers in ischemic stroke: a systematic review
title_fullStr The prognostic power of blood biomarkers in ischemic stroke: a systematic review
title_full_unstemmed The prognostic power of blood biomarkers in ischemic stroke: a systematic review
title_sort prognostic power of blood biomarkers in ischemic stroke: a systematic review
publisher IIUM Press
publishDate 2024
url http://irep.iium.edu.my/117465/9/117465_The%20prognostic%20power%20of%20blood%20biomarkers%20in%20ischemic%20stroke.pdf
http://irep.iium.edu.my/117465/
https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/941/862
https://doi.org/10.31436/ijahs.v8i5
_version_ 1821105146479771648
score 13.244413

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