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A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition

OBJECTIVES: This systematic literature review summarizes key findings from health economic evaluations in older adults with or at risk of malnutrition receiving oral nutrition supplement (ONS) interventions. METHODS: This review utilized six electronic databases (PubMed, Embase, EconLit, CINAHL,...

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Main Authors: Desai, A, Dong, OM, Gautier, S, Johnson, T, Wong, A, Osman, Ahmed Mohamed Yehia, Harvey, J, Tran, TH, Holladay Ford, DM, Kerr, KW, Aggarwal, A, Mauskopf, J
Format: Article
Language:English
English
Published: Elsevier Ltd 2024
Subjects:
RM216 Diet Therapy. Clinical Nutrition
TX341 Nutrition. Foods and food supply
Online Access:http://irep.iium.edu.my/117289/13/117289_A%20systematic%20review%20of%20health%20economic%20evaluations.pdf
http://irep.iium.edu.my/117289/21/117289_A%20systematic%20review%20of%20health%20economic%20evaluations_Poster.pdf
http://irep.iium.edu.my/117289/
https://www.sciencedirect.com/science/article/abs/pii/S1098301524034806
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spelling my.iium.irep.1172892025-01-03T01:26:57Z http://irep.iium.edu.my/117289/ A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition Desai, A Dong, OM Gautier, S Johnson, T Wong, A Osman, Ahmed Mohamed Yehia Harvey, J Tran, TH Holladay Ford, DM Kerr, KW Aggarwal, A Mauskopf, J RM216 Diet Therapy. Clinical Nutrition TX341 Nutrition. Foods and food supply OBJECTIVES: This systematic literature review summarizes key findings from health economic evaluations in older adults with or at risk of malnutrition receiving oral nutrition supplement (ONS) interventions. METHODS: This review utilized six electronic databases (PubMed, Embase, EconLit, CINAHL, Cochrane, Scopus) to identify health economic evaluations comparing ONS versus any comparators among older adults published between January 2014-February 2024. Inclusion criteria were publication in English, full text, and population with mean age ≥60 years. The Consolidated Health Economic Evaluation Reporting Standards checklist informed data extraction and reporting quality. Methodological quality of studies was assessed using the Drummond 10-item checklist. This study was registered with PROSPERO (CRD42023459161). RESULTS: Of the 1,459 records identified and screened, 12 studies met the inclusion criteria (4 cost-effectiveness analyses [CEA], 2 cost-utility analyses [CUA], 3 budget-impact analyses [BIA], 1 cost-minimization analysis, 1 CEA plus CUA, 1 BIA plus CEA). Studies were conducted in hospital settings (n=6) in different countries (n=7), had time horizons ≤6 months (n=10), were trial-based (n=8), had usual care as comparators (n=10), and included both healthcare and intervention costs (n=11). Across all studies, ONS intervention costs were low, resulting in lower or slightly higher total healthcare costs (e.g., ONS cost of €189 and total healthcare costs €191 lower at 18 weeks vs. comparator). In 11 studies, ONS interventions had higher overall patient health outcomes vs. comparators (e.g., significantly faster pressure ulcer healing at 8 weeks). In 6 studies that reported quality-adjusted life-years (QALYs), ONS interventions resulted in slightly higher QALYs vs. comparators (e.g., 3-month incremental QALY gain of 0.011). All studies concluded ONS intervention was cost-effective or cost saving. CONCLUSIONS: ONS improves patient outcomes among at-risk or malnourished older adults in hospital and community settings at minimal costs to healthcare systems. Future studies with longer time horizons are needed to characterize longer-term benefits and costs of ONS interventions. Elsevier Ltd 2024-12 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/117289/13/117289_A%20systematic%20review%20of%20health%20economic%20evaluations.pdf application/pdf en http://irep.iium.edu.my/117289/21/117289_A%20systematic%20review%20of%20health%20economic%20evaluations_Poster.pdf Desai, A and Dong, OM and Gautier, S and Johnson, T and Wong, A and Osman, Ahmed Mohamed Yehia and Harvey, J and Tran, TH and Holladay Ford, DM and Kerr, KW and Aggarwal, A and Mauskopf, J (2024) A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition. Value in Health, 27 (12 (Suppl.)). S120-S120. ISSN 1098-3015 E-ISSN 1524-4733 https://www.sciencedirect.com/science/article/abs/pii/S1098301524034806 10.1016/j.jval.2024.10.617
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RM216 Diet Therapy. Clinical Nutrition
TX341 Nutrition. Foods and food supply
spellingShingle RM216 Diet Therapy. Clinical Nutrition
TX341 Nutrition. Foods and food supply
Desai, A
Dong, OM
Gautier, S
Johnson, T
Wong, A
Osman, Ahmed Mohamed Yehia
Harvey, J
Tran, TH
Holladay Ford, DM
Kerr, KW
Aggarwal, A
Mauskopf, J
A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition
description OBJECTIVES: This systematic literature review summarizes key findings from health economic evaluations in older adults with or at risk of malnutrition receiving oral nutrition supplement (ONS) interventions. METHODS: This review utilized six electronic databases (PubMed, Embase, EconLit, CINAHL, Cochrane, Scopus) to identify health economic evaluations comparing ONS versus any comparators among older adults published between January 2014-February 2024. Inclusion criteria were publication in English, full text, and population with mean age ≥60 years. The Consolidated Health Economic Evaluation Reporting Standards checklist informed data extraction and reporting quality. Methodological quality of studies was assessed using the Drummond 10-item checklist. This study was registered with PROSPERO (CRD42023459161). RESULTS: Of the 1,459 records identified and screened, 12 studies met the inclusion criteria (4 cost-effectiveness analyses [CEA], 2 cost-utility analyses [CUA], 3 budget-impact analyses [BIA], 1 cost-minimization analysis, 1 CEA plus CUA, 1 BIA plus CEA). Studies were conducted in hospital settings (n=6) in different countries (n=7), had time horizons ≤6 months (n=10), were trial-based (n=8), had usual care as comparators (n=10), and included both healthcare and intervention costs (n=11). Across all studies, ONS intervention costs were low, resulting in lower or slightly higher total healthcare costs (e.g., ONS cost of €189 and total healthcare costs €191 lower at 18 weeks vs. comparator). In 11 studies, ONS interventions had higher overall patient health outcomes vs. comparators (e.g., significantly faster pressure ulcer healing at 8 weeks). In 6 studies that reported quality-adjusted life-years (QALYs), ONS interventions resulted in slightly higher QALYs vs. comparators (e.g., 3-month incremental QALY gain of 0.011). All studies concluded ONS intervention was cost-effective or cost saving. CONCLUSIONS: ONS improves patient outcomes among at-risk or malnourished older adults in hospital and community settings at minimal costs to healthcare systems. Future studies with longer time horizons are needed to characterize longer-term benefits and costs of ONS interventions.
format Article
author Desai, A
Dong, OM
Gautier, S
Johnson, T
Wong, A
Osman, Ahmed Mohamed Yehia
Harvey, J
Tran, TH
Holladay Ford, DM
Kerr, KW
Aggarwal, A
Mauskopf, J
author_facet Desai, A
Dong, OM
Gautier, S
Johnson, T
Wong, A
Osman, Ahmed Mohamed Yehia
Harvey, J
Tran, TH
Holladay Ford, DM
Kerr, KW
Aggarwal, A
Mauskopf, J
author_sort Desai, A
title A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition
title_short A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition
title_full A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition
title_fullStr A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition
title_full_unstemmed A systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition
title_sort systematic review of health economic evaluations of oral nutritional supplements as a single-component or multi-component intervention in older adults with or at risk of malnutrition
publisher Elsevier Ltd
publishDate 2024
url http://irep.iium.edu.my/117289/13/117289_A%20systematic%20review%20of%20health%20economic%20evaluations.pdf
http://irep.iium.edu.my/117289/21/117289_A%20systematic%20review%20of%20health%20economic%20evaluations_Poster.pdf
http://irep.iium.edu.my/117289/
https://www.sciencedirect.com/science/article/abs/pii/S1098301524034806
_version_ 1821105133718601728
score 13.226497

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