Cover Image

Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis

Introduction: Acute appendicitis is the most common surgical emergency globally. Neuroma of the appendix, a rare neural-origin tumour, often mimics the symptoms of acute appendicitis. Case Presentation: We report a case of a 39-year-old female who presented with sudden right lower abdominal pain...

Full description

Saved in:
Bibliographic Details
Main Authors: Abd. Fuaat, Azliana, Azmi, Siti Nurhanisah, Hamdan, Asmah Hanim, Ahmad Affandi, Khairunisa
Format: Article
Language:English
Published: Academy of Medicine Malaysia 2024
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/117049/7/117049_Uncommon%20but%20crucial.pdf
http://irep.iium.edu.my/117049/
https://www.mjpath.org.my/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.117049
record_format dspace
spelling my.iium.irep.1170492025-01-07T01:57:27Z http://irep.iium.edu.my/117049/ Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis Abd. Fuaat, Azliana Azmi, Siti Nurhanisah Hamdan, Asmah Hanim Ahmad Affandi, Khairunisa RB Pathology Introduction: Acute appendicitis is the most common surgical emergency globally. Neuroma of the appendix, a rare neural-origin tumour, often mimics the symptoms of acute appendicitis. Case Presentation: We report a case of a 39-year-old female who presented with sudden right lower abdominal pain associated with vomiting, reduced oral intake, and nausea. Examination revealed right iliac fossa tenderness, positive rebound tenderness, and a positive Rovsing's sign. Laboratory tests showed leukocytosis with neutrophilia, and abdominal ultrasound indicated acute appendicitis. An appendicectomy was performed, revealing an inflamed retrocecal appendix forming a mass clump with the tip embedded in the cecum. Microscopically, the appendiceal lumen was obliterated by uniform spindle cell proliferation in a myxoid background, with mild neutrophilic infiltration at the serosa. Immunohistochemistry revealed spindle cells positive for S100 and negative for SMA. The final diagnosis was neuroma of the appendix with serositis. Discussion: Acute appendicitis is a common surgical emergency, typically resulting from luminal obstruction. While the common causes include fecaliths, lymphoid hyperplasia, and infections, rare etiologies such as neuroma of appendix are seldom reported. Neuroma of appendix are benign nerve tissue tumours within the mucosal layer, often associated with genetic syndromes but can occur sporadically. Their presence in the appendix leading to acute inflammation presents a unique diagnostic challenge and clinical interest. Conclusion: Neuroma of appendix, though rare, should be considered a potential cause of acute appendicitis. Recognition of this entity is crucial for pathologists and surgeons to ensure accurate diagnosis and appropriate management. Academy of Medicine Malaysia 2024-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/117049/7/117049_Uncommon%20but%20crucial.pdf Abd. Fuaat, Azliana and Azmi, Siti Nurhanisah and Hamdan, Asmah Hanim and Ahmad Affandi, Khairunisa (2024) Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis. Malaysian Journal of Pathology, 43. p. 467. ISSN 0126-8635 https://www.mjpath.org.my/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RB Pathology
spellingShingle RB Pathology
Abd. Fuaat, Azliana
Azmi, Siti Nurhanisah
Hamdan, Asmah Hanim
Ahmad Affandi, Khairunisa
Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis
description Introduction: Acute appendicitis is the most common surgical emergency globally. Neuroma of the appendix, a rare neural-origin tumour, often mimics the symptoms of acute appendicitis. Case Presentation: We report a case of a 39-year-old female who presented with sudden right lower abdominal pain associated with vomiting, reduced oral intake, and nausea. Examination revealed right iliac fossa tenderness, positive rebound tenderness, and a positive Rovsing's sign. Laboratory tests showed leukocytosis with neutrophilia, and abdominal ultrasound indicated acute appendicitis. An appendicectomy was performed, revealing an inflamed retrocecal appendix forming a mass clump with the tip embedded in the cecum. Microscopically, the appendiceal lumen was obliterated by uniform spindle cell proliferation in a myxoid background, with mild neutrophilic infiltration at the serosa. Immunohistochemistry revealed spindle cells positive for S100 and negative for SMA. The final diagnosis was neuroma of the appendix with serositis. Discussion: Acute appendicitis is a common surgical emergency, typically resulting from luminal obstruction. While the common causes include fecaliths, lymphoid hyperplasia, and infections, rare etiologies such as neuroma of appendix are seldom reported. Neuroma of appendix are benign nerve tissue tumours within the mucosal layer, often associated with genetic syndromes but can occur sporadically. Their presence in the appendix leading to acute inflammation presents a unique diagnostic challenge and clinical interest. Conclusion: Neuroma of appendix, though rare, should be considered a potential cause of acute appendicitis. Recognition of this entity is crucial for pathologists and surgeons to ensure accurate diagnosis and appropriate management.
format Article
author Abd. Fuaat, Azliana
Azmi, Siti Nurhanisah
Hamdan, Asmah Hanim
Ahmad Affandi, Khairunisa
author_facet Abd. Fuaat, Azliana
Azmi, Siti Nurhanisah
Hamdan, Asmah Hanim
Ahmad Affandi, Khairunisa
author_sort Abd. Fuaat, Azliana
title Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis
title_short Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis
title_full Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis
title_fullStr Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis
title_full_unstemmed Uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis
title_sort uncommon but crucial: neuroma of appendix as a rare aetiology of acute appendicitis
publisher Academy of Medicine Malaysia
publishDate 2024
url http://irep.iium.edu.my/117049/7/117049_Uncommon%20but%20crucial.pdf
http://irep.iium.edu.my/117049/
https://www.mjpath.org.my/
_version_ 1821105121735475200
score 13.23648

Similar Items