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LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction

INTRODUCTION: An early onset of acute myocardial infarction (AMI) and a strong family history suggest the possibility of its genetic predisposition. Lipoprotein(a) (LPA) and Apolipoprotein E (APOE) genes are known to be involved in lipid metabolism which may contribute to the development of atherosc...

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Main Authors: Mohd Zamri, Iffah Irdhina, Abdullah, Nor Zamzila, A. Talib, Norlelawati, Muhammad Musa, Nurul Ashikin, Abdullah, Aszrin
Format: Article
Language:English
English
English
Published: Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia. 2024
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/116832/1/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE.pdf
http://irep.iium.edu.my/116832/6/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE_scopus.pdf
http://irep.iium.edu.my/116832/13/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE_WoS.pdf
http://irep.iium.edu.my/116832/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/2418
https://doi.org/10.31436/imjm.v23i02.2418
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spelling my.iium.irep.1168322024-12-19T07:02:41Z http://irep.iium.edu.my/116832/ LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction Mohd Zamri, Iffah Irdhina Abdullah, Nor Zamzila A. Talib, Norlelawati Muhammad Musa, Nurul Ashikin Abdullah, Aszrin R Medicine (General) INTRODUCTION: An early onset of acute myocardial infarction (AMI) and a strong family history suggest the possibility of its genetic predisposition. Lipoprotein(a) (LPA) and Apolipoprotein E (APOE) genes are known to be involved in lipid metabolism which may contribute to the development of atherosclerosis leading to AMI. This study aims to assess the association between LPA gene copy number variation (CNV) and APOE gene polymorphism in young AMI patients. MATERIALS AND METHODS: A total of 40 DNAs were extracted from the buffy coat. APOE genotyping and detection of LPA gene CNV were performed using multiplex PCR technique and digital PCR. After tabulation of the results of the current study, meta-analyses were performed from selected studies among Asian populations using the Comprehensive Meta-analysis version 3 software program. RESULTS: No significant association was found between CNV of the LPA gene and the polymorphism of the APOE gene with Young AMI patients in the current study. However, our meta-analysis confirmed that the E4 allele increased the risk for CAD with the E3/E4 genotype [p=0.000, OR= 1.60 (95% CI: 1.41-1.83) significantly increased risk of CAD and individuals with E3/E3 genotype [p=0.000, OR=0.73 (95% CI: 0.66-0.81) were protective against CAD. The gain of LPA CNV was higher in YAMI [n=5 (25%)] than in control [n=2 (10%)] but they are not significant. CONCLUSION: There is no association between the LPA gene CNV and the presence of APOE polymorphism in young AMI, but our meta-analysis confirmed that the E4 allele increased the risk for CAD. Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia. 2024-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/116832/1/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE.pdf application/pdf en http://irep.iium.edu.my/116832/6/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE_scopus.pdf application/pdf en http://irep.iium.edu.my/116832/13/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE_WoS.pdf Mohd Zamri, Iffah Irdhina and Abdullah, Nor Zamzila and A. Talib, Norlelawati and Muhammad Musa, Nurul Ashikin and Abdullah, Aszrin (2024) LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction. IIUM Medical Journal Malaysia, 23 (2). pp. 47-55. ISSN 1823-4631 E-ISSN 2735-2285 https://journals.iium.edu.my/kom/index.php/imjm/article/view/2418 https://doi.org/10.31436/imjm.v23i02.2418
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Mohd Zamri, Iffah Irdhina
Abdullah, Nor Zamzila
A. Talib, Norlelawati
Muhammad Musa, Nurul Ashikin
Abdullah, Aszrin
LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction
description INTRODUCTION: An early onset of acute myocardial infarction (AMI) and a strong family history suggest the possibility of its genetic predisposition. Lipoprotein(a) (LPA) and Apolipoprotein E (APOE) genes are known to be involved in lipid metabolism which may contribute to the development of atherosclerosis leading to AMI. This study aims to assess the association between LPA gene copy number variation (CNV) and APOE gene polymorphism in young AMI patients. MATERIALS AND METHODS: A total of 40 DNAs were extracted from the buffy coat. APOE genotyping and detection of LPA gene CNV were performed using multiplex PCR technique and digital PCR. After tabulation of the results of the current study, meta-analyses were performed from selected studies among Asian populations using the Comprehensive Meta-analysis version 3 software program. RESULTS: No significant association was found between CNV of the LPA gene and the polymorphism of the APOE gene with Young AMI patients in the current study. However, our meta-analysis confirmed that the E4 allele increased the risk for CAD with the E3/E4 genotype [p=0.000, OR= 1.60 (95% CI: 1.41-1.83) significantly increased risk of CAD and individuals with E3/E3 genotype [p=0.000, OR=0.73 (95% CI: 0.66-0.81) were protective against CAD. The gain of LPA CNV was higher in YAMI [n=5 (25%)] than in control [n=2 (10%)] but they are not significant. CONCLUSION: There is no association between the LPA gene CNV and the presence of APOE polymorphism in young AMI, but our meta-analysis confirmed that the E4 allele increased the risk for CAD.
format Article
author Mohd Zamri, Iffah Irdhina
Abdullah, Nor Zamzila
A. Talib, Norlelawati
Muhammad Musa, Nurul Ashikin
Abdullah, Aszrin
author_facet Mohd Zamri, Iffah Irdhina
Abdullah, Nor Zamzila
A. Talib, Norlelawati
Muhammad Musa, Nurul Ashikin
Abdullah, Aszrin
author_sort Mohd Zamri, Iffah Irdhina
title LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction
title_short LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction
title_full LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction
title_fullStr LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction
title_full_unstemmed LPA gene copy number variation and APOE gene polymorphism in young acute myocardial infarction
title_sort lpa gene copy number variation and apoe gene polymorphism in young acute myocardial infarction
publisher Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia.
publishDate 2024
url http://irep.iium.edu.my/116832/1/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE.pdf
http://irep.iium.edu.my/116832/6/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE_scopus.pdf
http://irep.iium.edu.my/116832/13/116832_LPA%20gene%20copy%20number%20variation%20and%20APOE_WoS.pdf
http://irep.iium.edu.my/116832/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/2418
https://doi.org/10.31436/imjm.v23i02.2418
_version_ 1819909403087732736
score 13.223943

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