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Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis

INTRODUCTION: Tualang Honey, characterised by its anti-inflammatory and antioxidative properties, presents a novel therapeutic approach to osteoarthritis (OA) management. This study evaluates the efficacy of a Tualang Honey Formulation (THF) (Patent no. MY179303-A) injection, compared to Synvisc,...

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Main Authors: Abd Rahim, Nour El Huda, Mohamad Amri, Nur Fathonah, Zulkifly, Ahmad Hafiz, Hassan, Habibah, Mohd Jan, Nurul Hafiza, Ibrahim, Mohd Zulfadzli
Format: Article
Language:English
Published: Malaysian Orthopaedic Association (MOA) 2024
Subjects:
R Medicine (General)
RD Surgery
RD701 Orthopedics
Online Access:http://irep.iium.edu.my/116541/1/116541_Exploring%20Tualang%20Honey%20formulation.pdf
http://irep.iium.edu.my/116541/
https://www.morthoj.org/supplements/moa-2024/index.php
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spelling my.iium.irep.1165412024-12-10T07:09:08Z http://irep.iium.edu.my/116541/ Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis Abd Rahim, Nour El Huda Mohamad Amri, Nur Fathonah Zulkifly, Ahmad Hafiz Hassan, Habibah Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli R Medicine (General) RD Surgery RD701 Orthopedics INTRODUCTION: Tualang Honey, characterised by its anti-inflammatory and antioxidative properties, presents a novel therapeutic approach to osteoarthritis (OA) management. This study evaluates the efficacy of a Tualang Honey Formulation (THF) (Patent no. MY179303-A) injection, compared to Synvisc, a conventional hyaluronic acid injection, utilising radiographic findings in New Zealand White Rabbits (NZWR) as an OA model. MATERIALS & METHODS: A controlled experiment was conducted on 24 OA-induced NZWR. Two experimental groups received THF and Synvisc intraarticularly after 3 weeks post-surgery. The rabbits were then euthanised, and x-rays were taken at 3, 6, 12, and 24 weeks to evaluate joint space narrowing and subchondral sclerosis as indicators of OA progression. RESULTS: At 3 and 6 weeks, both groups demonstrated an improving condition in radiographic signs of OA, with no significant difference between them. At 12 weeks, the THF group showed a trend towards better preservation of joint space. By 24 weeks, the radiographic outcomes of THF were comparable to the Synvisc group, with no significant differences of OA progression. DISCUSSIONS: The findings suggest that THF may offer a comparable alternative to Synvisc injections in managing OA, with the potential benefits of natural and halal composition and lower cost. However, further studies are needed to assess the long-term clinical outcomes and potential systemic effects of THF. CONCLUSION: THF injection is as effective as Synvisc hyaluronic acid injection in reducing radiographic signs of OA in New Zealand White Rabbits at 24 weeks, making it a potential candidate as a viscosupplement in the non-surgical management of OA. Malaysian Orthopaedic Association (MOA) 2024-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/116541/1/116541_Exploring%20Tualang%20Honey%20formulation.pdf Abd Rahim, Nour El Huda and Mohamad Amri, Nur Fathonah and Zulkifly, Ahmad Hafiz and Hassan, Habibah and Mohd Jan, Nurul Hafiza and Ibrahim, Mohd Zulfadzli (2024) Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis. Malaysian Orthopaedic Journal, 17 (Suppl. A). p. 1. ISSN 1985-2533 E-ISSN 2232-111X https://www.morthoj.org/supplements/moa-2024/index.php
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RD Surgery
RD701 Orthopedics
spellingShingle R Medicine (General)
RD Surgery
RD701 Orthopedics
Abd Rahim, Nour El Huda
Mohamad Amri, Nur Fathonah
Zulkifly, Ahmad Hafiz
Hassan, Habibah
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis
description INTRODUCTION: Tualang Honey, characterised by its anti-inflammatory and antioxidative properties, presents a novel therapeutic approach to osteoarthritis (OA) management. This study evaluates the efficacy of a Tualang Honey Formulation (THF) (Patent no. MY179303-A) injection, compared to Synvisc, a conventional hyaluronic acid injection, utilising radiographic findings in New Zealand White Rabbits (NZWR) as an OA model. MATERIALS & METHODS: A controlled experiment was conducted on 24 OA-induced NZWR. Two experimental groups received THF and Synvisc intraarticularly after 3 weeks post-surgery. The rabbits were then euthanised, and x-rays were taken at 3, 6, 12, and 24 weeks to evaluate joint space narrowing and subchondral sclerosis as indicators of OA progression. RESULTS: At 3 and 6 weeks, both groups demonstrated an improving condition in radiographic signs of OA, with no significant difference between them. At 12 weeks, the THF group showed a trend towards better preservation of joint space. By 24 weeks, the radiographic outcomes of THF were comparable to the Synvisc group, with no significant differences of OA progression. DISCUSSIONS: The findings suggest that THF may offer a comparable alternative to Synvisc injections in managing OA, with the potential benefits of natural and halal composition and lower cost. However, further studies are needed to assess the long-term clinical outcomes and potential systemic effects of THF. CONCLUSION: THF injection is as effective as Synvisc hyaluronic acid injection in reducing radiographic signs of OA in New Zealand White Rabbits at 24 weeks, making it a potential candidate as a viscosupplement in the non-surgical management of OA.
format Article
author Abd Rahim, Nour El Huda
Mohamad Amri, Nur Fathonah
Zulkifly, Ahmad Hafiz
Hassan, Habibah
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
author_facet Abd Rahim, Nour El Huda
Mohamad Amri, Nur Fathonah
Zulkifly, Ahmad Hafiz
Hassan, Habibah
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
author_sort Abd Rahim, Nour El Huda
title Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis
title_short Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis
title_full Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis
title_fullStr Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis
title_full_unstemmed Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis
title_sort exploring tualang honey formulation and synvisc in rabbit osteoarthritis
publisher Malaysian Orthopaedic Association (MOA)
publishDate 2024
url http://irep.iium.edu.my/116541/1/116541_Exploring%20Tualang%20Honey%20formulation.pdf
http://irep.iium.edu.my/116541/
https://www.morthoj.org/supplements/moa-2024/index.php
_version_ 1818833720304467968
score 13.235796

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