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Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading

Mesoporous silica (MPS), a carrier for active pharmaceutical ingredients, has a wide range of particle and pore morphology. A thorough understanding of ingredients used in MPS synthesis is an important prerequisite for optimizing its physicochemical characteristics. The present study aimed to evalua...

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Main Authors:	Oo, May Kyaw, Alallam, Batoul, Doolaanea, Abd Almonem, Khatib, Alfi, Mohamed, Farahidah, Chatterjee, Bappaditya
Format:	Article
Language:	English English English
Published:	American Chemical Society 2022
Subjects:	RC Internal medicine RC627 Specialties of Internal Medicine-Metabolic Diseases RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/116382/7/116382_%20Exploring%20the%20effect%20of%20Glycerol%20and%20Hydrochloric%20Acid.pdf http://irep.iium.edu.my/116382/8/116382_%20Exploring%20the%20effect%20of%20Glycerol%20and%20Hydrochloric%20Acid_Scopus.pdf http://irep.iium.edu.my/116382/19/116382_Exploring%20the%20Effect%20of%20Glycerol%20and%20Hydrochloric%20Acid_WoS.pdf http://irep.iium.edu.my/116382/
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spelling	my.iium.irep.1163822024-12-05T06:15:45Z http://irep.iium.edu.my/116382/ Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading Oo, May Kyaw Alallam, Batoul Doolaanea, Abd Almonem Khatib, Alfi Mohamed, Farahidah Chatterjee, Bappaditya RC Internal medicine RC627 Specialties of Internal Medicine-Metabolic Diseases RS192 Materia Medica-Pharmaceutical Technology Mesoporous silica (MPS), a carrier for active pharmaceutical ingredients, has a wide range of particle and pore morphology. A thorough understanding of ingredients used in MPS synthesis is an important prerequisite for optimizing its physicochemical characteristics. The present study aimed to evaluate the effect of glycerol and hydrochloric acid on the characteristics of synthesized MPS. Ordered MPS materials were synthesized using the pluronic P123 template and tetraethyl orthosilicate (TEOS) precursor. A three-level factorial design was employed to study the interaction between glycerol and hydrochloric acid. The optimized MPS particles were reasonably uniform in shape (short and rod shaped) and < 1 μm in size with a smooth surface morphology. The nitrogen adsorption−desorption analysis revealed that the uniform cylindrical pores of the prepared MPS had a diameter > 5 nm and a total surface area > 500 m2 /g. With increasing acid and glycerol concentrations, the particle size of MPS decreased. However, while the glycerol increased the heterogeneity of the synthesized particles, the acid decreased it. The developed MPS was successfully loaded with a biological drug (insulin) with a 21.94% encapsulation efficiency. The MPS prepared in this study exhibits potential applications as a drug delivery carrier for drugs with a large molecular weight. American Chemical Society 2022-08-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/116382/7/116382_%20Exploring%20the%20effect%20of%20Glycerol%20and%20Hydrochloric%20Acid.pdf application/pdf en http://irep.iium.edu.my/116382/8/116382_%20Exploring%20the%20effect%20of%20Glycerol%20and%20Hydrochloric%20Acid_Scopus.pdf application/pdf en http://irep.iium.edu.my/116382/19/116382_Exploring%20the%20Effect%20of%20Glycerol%20and%20Hydrochloric%20Acid_WoS.pdf Oo, May Kyaw and Alallam, Batoul and Doolaanea, Abd Almonem and Khatib, Alfi and Mohamed, Farahidah and Chatterjee, Bappaditya (2022) Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading. ACS Omega, 7 (31). pp. 27126-27134. ISSN 2470-1343 10.1021/acsomega.2c01386
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English English
topic	RC Internal medicine RC627 Specialties of Internal Medicine-Metabolic Diseases RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RC Internal medicine RC627 Specialties of Internal Medicine-Metabolic Diseases RS192 Materia Medica-Pharmaceutical Technology Oo, May Kyaw Alallam, Batoul Doolaanea, Abd Almonem Khatib, Alfi Mohamed, Farahidah Chatterjee, Bappaditya Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading
description	Mesoporous silica (MPS), a carrier for active pharmaceutical ingredients, has a wide range of particle and pore morphology. A thorough understanding of ingredients used in MPS synthesis is an important prerequisite for optimizing its physicochemical characteristics. The present study aimed to evaluate the effect of glycerol and hydrochloric acid on the characteristics of synthesized MPS. Ordered MPS materials were synthesized using the pluronic P123 template and tetraethyl orthosilicate (TEOS) precursor. A three-level factorial design was employed to study the interaction between glycerol and hydrochloric acid. The optimized MPS particles were reasonably uniform in shape (short and rod shaped) and < 1 μm in size with a smooth surface morphology. The nitrogen adsorption−desorption analysis revealed that the uniform cylindrical pores of the prepared MPS had a diameter > 5 nm and a total surface area > 500 m2 /g. With increasing acid and glycerol concentrations, the particle size of MPS decreased. However, while the glycerol increased the heterogeneity of the synthesized particles, the acid decreased it. The developed MPS was successfully loaded with a biological drug (insulin) with a 21.94% encapsulation efficiency. The MPS prepared in this study exhibits potential applications as a drug delivery carrier for drugs with a large molecular weight.
format	Article
author	Oo, May Kyaw Alallam, Batoul Doolaanea, Abd Almonem Khatib, Alfi Mohamed, Farahidah Chatterjee, Bappaditya
author_facet	Oo, May Kyaw Alallam, Batoul Doolaanea, Abd Almonem Khatib, Alfi Mohamed, Farahidah Chatterjee, Bappaditya
author_sort	Oo, May Kyaw
title	Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading
title_short	Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading
title_full	Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading
title_fullStr	Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading
title_full_unstemmed	Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading
title_sort	exploring the effect of glycerol and hydrochloric acid on mesoporous silica synthesis: application in insulin loading
publisher	American Chemical Society
publishDate	2022
url	http://irep.iium.edu.my/116382/7/116382_%20Exploring%20the%20effect%20of%20Glycerol%20and%20Hydrochloric%20Acid.pdf http://irep.iium.edu.my/116382/8/116382_%20Exploring%20the%20effect%20of%20Glycerol%20and%20Hydrochloric%20Acid_Scopus.pdf http://irep.iium.edu.my/116382/19/116382_Exploring%20the%20Effect%20of%20Glycerol%20and%20Hydrochloric%20Acid_WoS.pdf http://irep.iium.edu.my/116382/
_version_	1817841094241550336
score	13.223943

Exploring the effect of Glycerol and Hydrochloric Acid on Mesoporous Silica synthesis: Application in insulin loading

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