Cover Image

Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride

Non-compliance is a serious healthcare issue. It contributes to waste of medication, deterioration of patient’s quality of life and increase in healthcare cost. It is challenging to ensure Alzheimer's disease patients to comply to their medication daily. Hence, patient friendly and innovative d...

Full description

Saved in:
Bibliographic Details
Main Authors: Phang, Hiu Ching, Tan, Julia M, Subramaniam, Poonguzhali, Helal Uddin, A.B.M., Ee, Mei Hooi, Lakshminarayanan, Vijayakumar, Liew, Kai Bin
Format: Article
Language:English
English
Published: International Journal of Pharmaceutical Compounding, Inc. 2024
Subjects:
QD Chemistry
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS192 Materia Medica-Pharmaceutical Technology
RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:http://irep.iium.edu.my/116369/7/116369_Comparison%20of%20Oven%20Dried%20and%20Freeze%20Dried.pdf
http://irep.iium.edu.my/116369/8/116369_Comparison%20of%20Oven%20Dried%20and%20Freeze%20Dried_scopus.pdf
http://irep.iium.edu.my/116369/
https://ijpc.com/Abstracts/Abstract.cfm?ABS=5386
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.116369
record_format dspace
spelling my.iium.irep.1163692024-12-05T03:55:46Z http://irep.iium.edu.my/116369/ Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride Phang, Hiu Ching Tan, Julia M Subramaniam, Poonguzhali Helal Uddin, A.B.M. Ee, Mei Hooi Lakshminarayanan, Vijayakumar Liew, Kai Bin QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Non-compliance is a serious healthcare issue. It contributes to waste of medication, deterioration of patient’s quality of life and increase in healthcare cost. It is challenging to ensure Alzheimer's disease patients to comply to their medication daily. Hence, patient friendly and innovative dosage form is required to overcome the challenges. Orally disintegrating film (ODF) is proposed as solution to non-compliance. The objective of this research was to compare oven drying and freeze drying process on the physical properties of memantine hydrochloride ODF. A central composite design was used. The factors considered were concentration of Guar Gum (0.5–1.84g), concentration of wheat starch (0.5–1.84g) and concentration of PEG 400 (0.5–1.84g). A total of 20 formulations for each drying method were prepared. The ODFs produced were then characterized using uniformity of thickness tensile strength, folding endurance, disintegration time test. The optimum formulation was selected and incorporated with memantine hydrochloride. A flexible Memantine hydrochloride ODF formulation with fast disintegration time, sufficient mechanical strength and stable over a period of six months was successfully developed. The optimum formulation has 1.50 g guar gum, 1.50 g starch and 1.50 g of PEG 400. Freeze dried films are preferred as these films are more flexible and porous that lead to faster disintegration time. The findings suggest that memantine hydrochloride ODF has the potential as an alternative dosage form in treating Alzheimer’s disease. International Journal of Pharmaceutical Compounding, Inc. 2024-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/116369/7/116369_Comparison%20of%20Oven%20Dried%20and%20Freeze%20Dried.pdf application/pdf en http://irep.iium.edu.my/116369/8/116369_Comparison%20of%20Oven%20Dried%20and%20Freeze%20Dried_scopus.pdf Phang, Hiu Ching and Tan, Julia M and Subramaniam, Poonguzhali and Helal Uddin, A.B.M. and Ee, Mei Hooi and Lakshminarayanan, Vijayakumar and Liew, Kai Bin (2024) Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride. International Journal of Pharmaceutical Compounding, 28 (5). pp. 423-431. ISSN 1092-4221 https://ijpc.com/Abstracts/Abstract.cfm?ABS=5386
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QD Chemistry
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS192 Materia Medica-Pharmaceutical Technology
RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle QD Chemistry
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS192 Materia Medica-Pharmaceutical Technology
RS403 Materia Medica-Pharmaceutical Chemistry
Phang, Hiu Ching
Tan, Julia M
Subramaniam, Poonguzhali
Helal Uddin, A.B.M.
Ee, Mei Hooi
Lakshminarayanan, Vijayakumar
Liew, Kai Bin
Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride
description Non-compliance is a serious healthcare issue. It contributes to waste of medication, deterioration of patient’s quality of life and increase in healthcare cost. It is challenging to ensure Alzheimer's disease patients to comply to their medication daily. Hence, patient friendly and innovative dosage form is required to overcome the challenges. Orally disintegrating film (ODF) is proposed as solution to non-compliance. The objective of this research was to compare oven drying and freeze drying process on the physical properties of memantine hydrochloride ODF. A central composite design was used. The factors considered were concentration of Guar Gum (0.5–1.84g), concentration of wheat starch (0.5–1.84g) and concentration of PEG 400 (0.5–1.84g). A total of 20 formulations for each drying method were prepared. The ODFs produced were then characterized using uniformity of thickness tensile strength, folding endurance, disintegration time test. The optimum formulation was selected and incorporated with memantine hydrochloride. A flexible Memantine hydrochloride ODF formulation with fast disintegration time, sufficient mechanical strength and stable over a period of six months was successfully developed. The optimum formulation has 1.50 g guar gum, 1.50 g starch and 1.50 g of PEG 400. Freeze dried films are preferred as these films are more flexible and porous that lead to faster disintegration time. The findings suggest that memantine hydrochloride ODF has the potential as an alternative dosage form in treating Alzheimer’s disease.
format Article
author Phang, Hiu Ching
Tan, Julia M
Subramaniam, Poonguzhali
Helal Uddin, A.B.M.
Ee, Mei Hooi
Lakshminarayanan, Vijayakumar
Liew, Kai Bin
author_facet Phang, Hiu Ching
Tan, Julia M
Subramaniam, Poonguzhali
Helal Uddin, A.B.M.
Ee, Mei Hooi
Lakshminarayanan, Vijayakumar
Liew, Kai Bin
author_sort Phang, Hiu Ching
title Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride
title_short Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride
title_full Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride
title_fullStr Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride
title_full_unstemmed Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride
title_sort comparison of oven dried and freeze dried orally disintegrating film (odf) formulations containing memantine hydrochloride
publisher International Journal of Pharmaceutical Compounding, Inc.
publishDate 2024
url http://irep.iium.edu.my/116369/7/116369_Comparison%20of%20Oven%20Dried%20and%20Freeze%20Dried.pdf
http://irep.iium.edu.my/116369/8/116369_Comparison%20of%20Oven%20Dried%20and%20Freeze%20Dried_scopus.pdf
http://irep.iium.edu.my/116369/
https://ijpc.com/Abstracts/Abstract.cfm?ABS=5386
_version_ 1817841093663784960
score 13.223943

Similar Items