Staff View: Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride

Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride

Fast Melt Tablet (FMT) is a newer type of orally disintegrating tablet using the advantage of cocoa butter that melts at body temperature to achieve fast melting effect when the tablet is placed in oral cavity. However, oral disintegrating dosage form must have good palatability so that patients can...

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Main Authors:	Liew, Kai Bin, Chew, Yik Ling, Helal Uddin, A.B.M., Lee, Siew-Keah, Lakshminarayanan, Vijayakumar, Janakiraman, Ashok Kumar, Khalid, Syed Haroon, Ramanunny, Arya Kadukkattil, Xia, Yang
Format:	Article
Language:	English
Published:	International Journal of Pharmaceutical Compounding, Inc. 2024
Subjects:	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/116368/7/116368_Taste%20masking%20study%20of%20cocoa%20butter%20fast%20melt%20tablet.pdf http://irep.iium.edu.my/116368/ https://ijpc.com/Abstracts/Abstract.cfm?ABS=5407
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spelling	my.iium.irep.1163682024-12-05T03:29:28Z http://irep.iium.edu.my/116368/ Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride Liew, Kai Bin Chew, Yik Ling Helal Uddin, A.B.M. Lee, Siew-Keah Lakshminarayanan, Vijayakumar Janakiraman, Ashok Kumar Khalid, Syed Haroon Ramanunny, Arya Kadukkattil Xia, Yang QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Fast Melt Tablet (FMT) is a newer type of orally disintegrating tablet using the advantage of cocoa butter that melts at body temperature to achieve fast melting effect when the tablet is placed in oral cavity. However, oral disintegrating dosage form must have good palatability so that patients can accept it. The objective of this study is to taste mask a previously developed FMT containing memantine hydrochloride using artificial sweetener namely aspartame and acesulfame K and conduct a palatability study. Six formulations were developed and each sweetener was used at three level (10mg, 20mg and 30mg) to taste mask memantine hydrochloride in FMT. Formulation T7 was selected as the best taste masked formulation. Aspartame 30mg is sufficient to cover the bitter taste of memantine hydrochloride. A taste masked memantine hydrochloride FMT containing 30mg of aspartame was successfully developed. This formulation has hardness of 17.31 (0.18) Newton, 0.51 (0.02) g weight, 6.18 (0.42) mm thickness and in-vitro melting time of 31.16 (1.23) seconds. This novel dosage form has the potential to be commercialized as a patient friendly dosage form to treat Alzheimer’s disease. International Journal of Pharmaceutical Compounding, Inc. 2024-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/116368/7/116368_Taste%20masking%20study%20of%20cocoa%20butter%20fast%20melt%20tablet.pdf Liew, Kai Bin and Chew, Yik Ling and Helal Uddin, A.B.M. and Lee, Siew-Keah and Lakshminarayanan, Vijayakumar and Janakiraman, Ashok Kumar and Khalid, Syed Haroon and Ramanunny, Arya Kadukkattil and Xia, Yang (2024) Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride. International Journal of Pharmaceutical Compounding, 28 (6). pp. 502-508. ISSN 1092-4221 https://ijpc.com/Abstracts/Abstract.cfm?ABS=5407
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Liew, Kai Bin Chew, Yik Ling Helal Uddin, A.B.M. Lee, Siew-Keah Lakshminarayanan, Vijayakumar Janakiraman, Ashok Kumar Khalid, Syed Haroon Ramanunny, Arya Kadukkattil Xia, Yang Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride
description	Fast Melt Tablet (FMT) is a newer type of orally disintegrating tablet using the advantage of cocoa butter that melts at body temperature to achieve fast melting effect when the tablet is placed in oral cavity. However, oral disintegrating dosage form must have good palatability so that patients can accept it. The objective of this study is to taste mask a previously developed FMT containing memantine hydrochloride using artificial sweetener namely aspartame and acesulfame K and conduct a palatability study. Six formulations were developed and each sweetener was used at three level (10mg, 20mg and 30mg) to taste mask memantine hydrochloride in FMT. Formulation T7 was selected as the best taste masked formulation. Aspartame 30mg is sufficient to cover the bitter taste of memantine hydrochloride. A taste masked memantine hydrochloride FMT containing 30mg of aspartame was successfully developed. This formulation has hardness of 17.31 (0.18) Newton, 0.51 (0.02) g weight, 6.18 (0.42) mm thickness and in-vitro melting time of 31.16 (1.23) seconds. This novel dosage form has the potential to be commercialized as a patient friendly dosage form to treat Alzheimer’s disease.
format	Article
author	Liew, Kai Bin Chew, Yik Ling Helal Uddin, A.B.M. Lee, Siew-Keah Lakshminarayanan, Vijayakumar Janakiraman, Ashok Kumar Khalid, Syed Haroon Ramanunny, Arya Kadukkattil Xia, Yang
author_facet	Liew, Kai Bin Chew, Yik Ling Helal Uddin, A.B.M. Lee, Siew-Keah Lakshminarayanan, Vijayakumar Janakiraman, Ashok Kumar Khalid, Syed Haroon Ramanunny, Arya Kadukkattil Xia, Yang
author_sort	Liew, Kai Bin
title	Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride
title_short	Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride
title_full	Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride
title_fullStr	Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride
title_full_unstemmed	Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride
title_sort	taste masking study of cocoa butter fast melt tablet (fmt) formulations containing memantine hydrochloride
publisher	International Journal of Pharmaceutical Compounding, Inc.
publishDate	2024
url	http://irep.iium.edu.my/116368/7/116368_Taste%20masking%20study%20of%20cocoa%20butter%20fast%20melt%20tablet.pdf http://irep.iium.edu.my/116368/ https://ijpc.com/Abstracts/Abstract.cfm?ABS=5407
_version_	1817841093509644288
score	13.223943

Taste masking study of cocoa butter fast melt tablet (FMT) formulations containing memantine hydrochloride

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