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Isoniazid in children – any rationale for post isoniazid liver function test

Isoniazid (INH) therapy remains the treatment of choice in latent tuberculosis infection (LTBI). However, drug-induced liver injury (DILI) is a known adverse effect of isoniazid. Serum transaminase elevation occurs in about 10% of children receiving INH monotherapy. Drug-induced liver inj...

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Main Authors: Abdullah, Ahmad Fadzil, Rusli, Nur Shafinaz
Format: Article
Language:English
Published: Malaysian Paediatrics Association (MPA) 2022
Subjects:
R Medicine (General)
RJ Pediatrics
Online Access:http://irep.iium.edu.my/116079/1/ISONIAZID%20IN%20CHILDREN%20%E2%80%93%20ANY%20RATIONALE%20FOR%20POST%20ISONIAZID%20LIVER%20FUNCTION%20TEST.pdf
http://irep.iium.edu.my/116079/
https://mpaeds.my/journals/index.php/MJPCH/article/view/190/112
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spelling my.iium.irep.1160792024-11-25T23:53:39Z http://irep.iium.edu.my/116079/ Isoniazid in children – any rationale for post isoniazid liver function test Abdullah, Ahmad Fadzil Rusli, Nur Shafinaz R Medicine (General) RJ Pediatrics Isoniazid (INH) therapy remains the treatment of choice in latent tuberculosis infection (LTBI). However, drug-induced liver injury (DILI) is a known adverse effect of isoniazid. Serum transaminase elevation occurs in about 10% of children receiving INH monotherapy. Drug-induced liver injury can range from asymptomatic increase of aminotransferase to severe liver injury, or in some cases hepatic failure. Even though INH-induced liver injury has been known and extensively studied, its underlying mechanisms are still not fully understood. The liver injury comprises hepatotoxicity and a rarer form of hepatitis hypersensitive allergic reaction. Since the facility to do liver function (LFT) is widely available, monitoring liver function while on INH therapy is the wisest way of monitoring acute liver injury (ATLI). Malaysian Paediatrics Association (MPA) 2022-05-29 Article PeerReviewed application/pdf en http://irep.iium.edu.my/116079/1/ISONIAZID%20IN%20CHILDREN%20%E2%80%93%20ANY%20RATIONALE%20FOR%20POST%20ISONIAZID%20LIVER%20FUNCTION%20TEST.pdf Abdullah, Ahmad Fadzil and Rusli, Nur Shafinaz (2022) Isoniazid in children – any rationale for post isoniazid liver function test. Malaysian Journal of Paediatrics and Child Health (MJPCH), 28 (1). pp. 29-31. ISSN 1511-4511 https://mpaeds.my/journals/index.php/MJPCH/article/view/190/112 10.51407/mjpch.v28i1.190
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RJ Pediatrics
spellingShingle R Medicine (General)
RJ Pediatrics
Abdullah, Ahmad Fadzil
Rusli, Nur Shafinaz
Isoniazid in children – any rationale for post isoniazid liver function test
description Isoniazid (INH) therapy remains the treatment of choice in latent tuberculosis infection (LTBI). However, drug-induced liver injury (DILI) is a known adverse effect of isoniazid. Serum transaminase elevation occurs in about 10% of children receiving INH monotherapy. Drug-induced liver injury can range from asymptomatic increase of aminotransferase to severe liver injury, or in some cases hepatic failure. Even though INH-induced liver injury has been known and extensively studied, its underlying mechanisms are still not fully understood. The liver injury comprises hepatotoxicity and a rarer form of hepatitis hypersensitive allergic reaction. Since the facility to do liver function (LFT) is widely available, monitoring liver function while on INH therapy is the wisest way of monitoring acute liver injury (ATLI).
format Article
author Abdullah, Ahmad Fadzil
Rusli, Nur Shafinaz
author_facet Abdullah, Ahmad Fadzil
Rusli, Nur Shafinaz
author_sort Abdullah, Ahmad Fadzil
title Isoniazid in children – any rationale for post isoniazid liver function test
title_short Isoniazid in children – any rationale for post isoniazid liver function test
title_full Isoniazid in children – any rationale for post isoniazid liver function test
title_fullStr Isoniazid in children – any rationale for post isoniazid liver function test
title_full_unstemmed Isoniazid in children – any rationale for post isoniazid liver function test
title_sort isoniazid in children – any rationale for post isoniazid liver function test
publisher Malaysian Paediatrics Association (MPA)
publishDate 2022
url http://irep.iium.edu.my/116079/1/ISONIAZID%20IN%20CHILDREN%20%E2%80%93%20ANY%20RATIONALE%20FOR%20POST%20ISONIAZID%20LIVER%20FUNCTION%20TEST.pdf
http://irep.iium.edu.my/116079/
https://mpaeds.my/journals/index.php/MJPCH/article/view/190/112
_version_ 1817841063041171456
score 13.223943

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