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Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability

Preparation of serum in the form of extract nanoemulsions allows effective delivery of active ingredients to the skin due to the more stable nanoemulsions, lower viscosity, transparent visual aspects, and high surface area caused by the small globule size. This study aims to obtain an optimal 96% et...

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Main Authors: Harimurti, Sabtanti, Febriyani, Dwi, Sukamdi, Dyani Primasari, Widada, Hari, Amid, Azura
Format: Proceeding Paper
Language:English
Published: EDP Sciences 2024
Subjects:
TP Chemical technology
TP248.13 Biotechnology
Online Access:http://irep.iium.edu.my/116015/1/116015_Development%20of%20Mringa%20Leave%20Extract%20nanoemulsions.pdf
http://irep.iium.edu.my/116015/
https://www.bio-conferences.org/articles/bioconf/abs/2024/54/bioconf_icpu2024_03004/bioconf_icpu2024_03004.html
https://doi.org/10.1051/bioconf/202413503004
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spelling my.iium.irep.1160152024-11-21T05:45:30Z http://irep.iium.edu.my/116015/ Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability Harimurti, Sabtanti Febriyani, Dwi Sukamdi, Dyani Primasari Widada, Hari Amid, Azura TP Chemical technology TP248.13 Biotechnology Preparation of serum in the form of extract nanoemulsions allows effective delivery of active ingredients to the skin due to the more stable nanoemulsions, lower viscosity, transparent visual aspects, and high surface area caused by the small globule size. This study aims to obtain an optimal 96% ethanol concentration and sonication time in forming stable nanoemulsions at temperatures of 4° and 40°C with an active ingredient of moringa leaf extracts. The experiment was performed in four sets of 96% ethanol concentration (5%, 10%, 15%, and 20%) and three sonication periods (30, 60, and 90 minutes). The freeze-and-thaw method was utilized to evaluate the stability of the nanoemulsions. The analysis unveiled that a 96% ethanol concentration of 10% and a sonication time of 46 minutes was the most appropriate formula, generating a particle size of 30.49 nm with a volume of 73.35%. At the same time, the stability test of the preparation revealed that storage time significantly affected the pH response. However, it did not significantly affect the viscosity response. EDP Sciences 2024-11-07 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/116015/1/116015_Development%20of%20Mringa%20Leave%20Extract%20nanoemulsions.pdf Harimurti, Sabtanti and Febriyani, Dwi and Sukamdi, Dyani Primasari and Widada, Hari and Amid, Azura (2024) Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability. In: 4th International Conference on Pharmaceutical Updates (ICPU 2024), 7th-8th August 2024, Yogyakarta, Indonesia. https://www.bio-conferences.org/articles/bioconf/abs/2024/54/bioconf_icpu2024_03004/bioconf_icpu2024_03004.html https://doi.org/10.1051/bioconf/202413503004
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic TP Chemical technology
TP248.13 Biotechnology
spellingShingle TP Chemical technology
TP248.13 Biotechnology
Harimurti, Sabtanti
Febriyani, Dwi
Sukamdi, Dyani Primasari
Widada, Hari
Amid, Azura
Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability
description Preparation of serum in the form of extract nanoemulsions allows effective delivery of active ingredients to the skin due to the more stable nanoemulsions, lower viscosity, transparent visual aspects, and high surface area caused by the small globule size. This study aims to obtain an optimal 96% ethanol concentration and sonication time in forming stable nanoemulsions at temperatures of 4° and 40°C with an active ingredient of moringa leaf extracts. The experiment was performed in four sets of 96% ethanol concentration (5%, 10%, 15%, and 20%) and three sonication periods (30, 60, and 90 minutes). The freeze-and-thaw method was utilized to evaluate the stability of the nanoemulsions. The analysis unveiled that a 96% ethanol concentration of 10% and a sonication time of 46 minutes was the most appropriate formula, generating a particle size of 30.49 nm with a volume of 73.35%. At the same time, the stability test of the preparation revealed that storage time significantly affected the pH response. However, it did not significantly affect the viscosity response.
format Proceeding Paper
author Harimurti, Sabtanti
Febriyani, Dwi
Sukamdi, Dyani Primasari
Widada, Hari
Amid, Azura
author_facet Harimurti, Sabtanti
Febriyani, Dwi
Sukamdi, Dyani Primasari
Widada, Hari
Amid, Azura
author_sort Harimurti, Sabtanti
title Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability
title_short Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability
title_full Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability
title_fullStr Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability
title_full_unstemmed Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability
title_sort development of moringa leave extract nanoemulsions: effect of ethanol concentration and sonication toward the stability
publisher EDP Sciences
publishDate 2024
url http://irep.iium.edu.my/116015/1/116015_Development%20of%20Mringa%20Leave%20Extract%20nanoemulsions.pdf
http://irep.iium.edu.my/116015/
https://www.bio-conferences.org/articles/bioconf/abs/2024/54/bioconf_icpu2024_03004/bioconf_icpu2024_03004.html
https://doi.org/10.1051/bioconf/202413503004
_version_ 1817841060251959296
score 13.244413

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