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Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma

Osteosarcoma is one of the most common types of malignant bone tumors, typically involving long bones such as the femur, tibia, and humerus. However, osteosarcomas occurring in the jaws are exceptionally rare, accounting for approximately 7% of all osteosarcoma cases and just 1% of malignancie...

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Main Authors:	Lim Yung Chwen, Walter, Hamdan, Asmah Hanim, Zahari, Nurul Aifa, Abu Bakar, Intan Bazilah, Abdul Wahab, Azwan Halim
Format:	Article
Language:	English
Published:	Sciencedomain International 2024
Subjects:	RB Pathology RF Otorhinolaryngology
Online Access:	http://irep.iium.edu.my/115899/7/115899_Chondroblastic%20Osteosarcoma%20of%20the%20mandible%20An%20uncommon.pdf http://irep.iium.edu.my/115899/ https://journaljcti.com/index.php/JCTI/article/view/274 https://doi.org/10.9734/jcti/2024/v14i4274
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spelling	my.iium.irep.1158992024-11-20T04:01:49Z http://irep.iium.edu.my/115899/ Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma Lim Yung Chwen, Walter Hamdan, Asmah Hanim Zahari, Nurul Aifa Abu Bakar, Intan Bazilah Abdul Wahab, Azwan Halim RB Pathology RF Otorhinolaryngology Osteosarcoma is one of the most common types of malignant bone tumors, typically involving long bones such as the femur, tibia, and humerus. However, osteosarcomas occurring in the jaws are exceptionally rare, accounting for approximately 7% of all osteosarcoma cases and just 1% of malignancies in the head and neck region. This type of tumor usually affects individuals in their second and third decades of life. The subtypes of osteosarcoma include osteoblastic, chondroblastic, fibroblastic, small cell, and epithelioid. Chondroblastic osteosarcoma is associated with a poor prognosis, marked by a high recurrence rate, metastatic potential, and poor long-term survival outcomes. Here, we present the case of a 65-year-old woman with a painless swelling over the left cheek for 1 year, which significantly increased in size over the past 3 months, accompanied by trismus, reduced oral intake, and weight loss. Examination revealed a non-tender, hard swelling on the left cheek measuring 20x20cm, with prominent dilated veins. The left external auditory canal was collapsed due to the mass effect. Histopathological examination resulted as chondroblastic osteosarcoma of the left mandible. Computer tomography showed a large lobulated enhancing mass occupying the left cheek, associated with bone erosion and an aggressive periosteal reaction resembling a 'sunburst' pattern involving the ramus extending to the angle of the left mandible. The patient undergone open tracheostomy, left temporary tarsorrhaphy, wide local excision of tumor, left hemimandibulectomy, left partial maxillectomy and anterolateral thigh free flap reconstruction as patient unable to tolerate neoadjuvant chemotherapy Sciencedomain International 2024-11-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/115899/7/115899_Chondroblastic%20Osteosarcoma%20of%20the%20mandible%20An%20uncommon.pdf Lim Yung Chwen, Walter and Hamdan, Asmah Hanim and Zahari, Nurul Aifa and Abu Bakar, Intan Bazilah and Abdul Wahab, Azwan Halim (2024) Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma. Journal of Cancer and Tumor International, 14 (4). pp. 126-133. ISSN 2454-7360 https://journaljcti.com/index.php/JCTI/article/view/274 https://doi.org/10.9734/jcti/2024/v14i4274
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	RB Pathology RF Otorhinolaryngology
spellingShingle	RB Pathology RF Otorhinolaryngology Lim Yung Chwen, Walter Hamdan, Asmah Hanim Zahari, Nurul Aifa Abu Bakar, Intan Bazilah Abdul Wahab, Azwan Halim Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma
description	Osteosarcoma is one of the most common types of malignant bone tumors, typically involving long bones such as the femur, tibia, and humerus. However, osteosarcomas occurring in the jaws are exceptionally rare, accounting for approximately 7% of all osteosarcoma cases and just 1% of malignancies in the head and neck region. This type of tumor usually affects individuals in their second and third decades of life. The subtypes of osteosarcoma include osteoblastic, chondroblastic, fibroblastic, small cell, and epithelioid. Chondroblastic osteosarcoma is associated with a poor prognosis, marked by a high recurrence rate, metastatic potential, and poor long-term survival outcomes. Here, we present the case of a 65-year-old woman with a painless swelling over the left cheek for 1 year, which significantly increased in size over the past 3 months, accompanied by trismus, reduced oral intake, and weight loss. Examination revealed a non-tender, hard swelling on the left cheek measuring 20x20cm, with prominent dilated veins. The left external auditory canal was collapsed due to the mass effect. Histopathological examination resulted as chondroblastic osteosarcoma of the left mandible. Computer tomography showed a large lobulated enhancing mass occupying the left cheek, associated with bone erosion and an aggressive periosteal reaction resembling a 'sunburst' pattern involving the ramus extending to the angle of the left mandible. The patient undergone open tracheostomy, left temporary tarsorrhaphy, wide local excision of tumor, left hemimandibulectomy, left partial maxillectomy and anterolateral thigh free flap reconstruction as patient unable to tolerate neoadjuvant chemotherapy
format	Article
author	Lim Yung Chwen, Walter Hamdan, Asmah Hanim Zahari, Nurul Aifa Abu Bakar, Intan Bazilah Abdul Wahab, Azwan Halim
author_facet	Lim Yung Chwen, Walter Hamdan, Asmah Hanim Zahari, Nurul Aifa Abu Bakar, Intan Bazilah Abdul Wahab, Azwan Halim
author_sort	Lim Yung Chwen, Walter
title	Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma
title_short	Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma
title_full	Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma
title_fullStr	Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma
title_full_unstemmed	Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma
title_sort	chondroblastic osteosarcoma of the mandible: an uncommon site for osteosarcoma
publisher	Sciencedomain International
publishDate	2024
url	http://irep.iium.edu.my/115899/7/115899_Chondroblastic%20Osteosarcoma%20of%20the%20mandible%20An%20uncommon.pdf http://irep.iium.edu.my/115899/ https://journaljcti.com/index.php/JCTI/article/view/274 https://doi.org/10.9734/jcti/2024/v14i4274
_version_	1817841050397442048
score	13.23648

Chondroblastic Osteosarcoma of the mandible: an uncommon site for Osteosarcoma

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