Staff View: Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis

Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis

Objective: and rationale: Odontogenic myxoma is an uncommon odontogenic tumor with locally aggressive behavior. The clinicopathological studies of odontogenic myxoma in Asian countries are very limited and only few studies have investigated the immunohistochemical profiles of the tumor. This study a...

Full description

Saved in:

Bibliographic Details
Main Authors:	Juengsomjit, Rachai, Arayasantiparb, Raweewan, Ghazali, Ahmad Badruddin, Kosanwat, Theerachai
Format:	Article
Language:	English
Published:	Elselvier 2024
Subjects:	RK Dentistry RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works RK529 Oral Surgery-General Works
Online Access:	http://irep.iium.edu.my/115092/2/115092_Odontogenic%20myxoma.pdf http://irep.iium.edu.my/115092/ https://www.sciencedirect.com/science/article/pii/S2405844024151894/pdfft?md5=dff58f20d6ab639a763154586b99d878&pid=1-s2.0-S2405844024151894-main.pdf https://doi.org/10.1016/j.heliyon.2024.e39158
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.iium.irep.115092
record_format	dspace
spelling	my.iium.irep.1150922024-10-15T08:11:03Z http://irep.iium.edu.my/115092/ Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis Juengsomjit, Rachai Arayasantiparb, Raweewan Ghazali, Ahmad Badruddin Kosanwat, Theerachai RK Dentistry RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works RK529 Oral Surgery-General Works Objective: and rationale: Odontogenic myxoma is an uncommon odontogenic tumor with locally aggressive behavior. The clinicopathological studies of odontogenic myxoma in Asian countries are very limited and only few studies have investigated the immunohistochemical profiles of the tumor. This study aims to investigate the clinicopathological and immunohistochemical features of odontogenic myxoma at the Faculty of Dentistry, Mahidol University over a 15-year period. Methods: Archives of our institute were reviewed. Cases diagnosed as odontogenic myxoma were retrieved. Demographic, clinical, radiographic, and histopathological features of these cases were analyzed. In addition, immunohistochemical markers including vimentin, Ki-67, Bcl-2, and CD117 were performed. The correlation between immunohistochemical profiles and clinicopathological characteristics was evaluated. Results: Sixteen cases of odontogenic myxoma were discovered. Fourteen cases were central type while two cases were peripheral type. The mean age of patients was 34.6 years with male-tof emale ratio of 1:2.2. Mandible (68.8 %) was more affected than the maxilla (31.2 %). Bony expansion or jaw swelling (43.8 %) was the most common clinical feature. Most cases (71.4 %) presented with multilocular radiolucency. Histopathologically, tumors show stellate and pindle shaped cells in a myxoid stroma with varying amounts of collagen fiber. All cases were positive for vimentin and Bcl-2. Half of the cases showed positive for Ki-67. Mast cells were presented in most cases (75.0 %). A significant correlation was found between the immunoexpression level of Bcl-2 and border of lesion in radiograph (p = 0.024). Conclusions: This study contributes to better understanding of the characteristics of odontogenic myxoma. Clinicians and pathologists should be aware of odontogenic myxoma, as its clinical and histopathological features may overlap with other tumors. The expression of Bcl-2 and presence of mast cell in this tumor may relate to its growth and aggressiveness. Despite its benign nature, odontogenic myxoma exhibits high recurrence, especially in lesion managed conservatively. Elselvier 2024-10-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/115092/2/115092_Odontogenic%20myxoma.pdf Juengsomjit, Rachai and Arayasantiparb, Raweewan and Ghazali, Ahmad Badruddin and Kosanwat, Theerachai (2024) Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis. Heliyon, 10 (20). pp. 1-11. E-ISSN 2405-8440 https://www.sciencedirect.com/science/article/pii/S2405844024151894/pdfft?md5=dff58f20d6ab639a763154586b99d878&pid=1-s2.0-S2405844024151894-main.pdf https://doi.org/10.1016/j.heliyon.2024.e39158
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	RK Dentistry RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works RK529 Oral Surgery-General Works
spellingShingle	RK Dentistry RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works RK529 Oral Surgery-General Works Juengsomjit, Rachai Arayasantiparb, Raweewan Ghazali, Ahmad Badruddin Kosanwat, Theerachai Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis
description	Objective: and rationale: Odontogenic myxoma is an uncommon odontogenic tumor with locally aggressive behavior. The clinicopathological studies of odontogenic myxoma in Asian countries are very limited and only few studies have investigated the immunohistochemical profiles of the tumor. This study aims to investigate the clinicopathological and immunohistochemical features of odontogenic myxoma at the Faculty of Dentistry, Mahidol University over a 15-year period. Methods: Archives of our institute were reviewed. Cases diagnosed as odontogenic myxoma were retrieved. Demographic, clinical, radiographic, and histopathological features of these cases were analyzed. In addition, immunohistochemical markers including vimentin, Ki-67, Bcl-2, and CD117 were performed. The correlation between immunohistochemical profiles and clinicopathological characteristics was evaluated. Results: Sixteen cases of odontogenic myxoma were discovered. Fourteen cases were central type while two cases were peripheral type. The mean age of patients was 34.6 years with male-tof emale ratio of 1:2.2. Mandible (68.8 %) was more affected than the maxilla (31.2 %). Bony expansion or jaw swelling (43.8 %) was the most common clinical feature. Most cases (71.4 %) presented with multilocular radiolucency. Histopathologically, tumors show stellate and pindle shaped cells in a myxoid stroma with varying amounts of collagen fiber. All cases were positive for vimentin and Bcl-2. Half of the cases showed positive for Ki-67. Mast cells were presented in most cases (75.0 %). A significant correlation was found between the immunoexpression level of Bcl-2 and border of lesion in radiograph (p = 0.024). Conclusions: This study contributes to better understanding of the characteristics of odontogenic myxoma. Clinicians and pathologists should be aware of odontogenic myxoma, as its clinical and histopathological features may overlap with other tumors. The expression of Bcl-2 and presence of mast cell in this tumor may relate to its growth and aggressiveness. Despite its benign nature, odontogenic myxoma exhibits high recurrence, especially in lesion managed conservatively.
format	Article
author	Juengsomjit, Rachai Arayasantiparb, Raweewan Ghazali, Ahmad Badruddin Kosanwat, Theerachai
author_facet	Juengsomjit, Rachai Arayasantiparb, Raweewan Ghazali, Ahmad Badruddin Kosanwat, Theerachai
author_sort	Juengsomjit, Rachai
title	Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis
title_short	Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis
title_full	Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis
title_fullStr	Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis
title_full_unstemmed	Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis
title_sort	odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis
publisher	Elselvier
publishDate	2024
url	http://irep.iium.edu.my/115092/2/115092_Odontogenic%20myxoma.pdf http://irep.iium.edu.my/115092/ https://www.sciencedirect.com/science/article/pii/S2405844024151894/pdfft?md5=dff58f20d6ab639a763154586b99d878&pid=1-s2.0-S2405844024151894-main.pdf https://doi.org/10.1016/j.heliyon.2024.e39158
_version_	1814042742165078016
score	13.211869

Odontogenic myxoma: a clinicopathological study over 15 years and immunohistochemical analysis

Similar Items