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Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration

Introduction: Adult zebrafish are increasingly used in Parkinson’s disease (PD) research due to their well-characterized dopaminergic system. Among the toxin-based models, the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely utilized to induce parkinsonism in adult zebrafish....

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Main Authors: Razali, Khairiah, Kumar, Jaya, Mohamed, Wael Mohamed Yousef
Format: Article
Language:English
English
Published: Frontiers 2024
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/114376/7/114376_Characterizing%20the%20adult%20zebrafish%20model%20of%20Parkinson%E2%80%99s%20disease.pdf
http://irep.iium.edu.my/114376/13/114376_Characterizing%20the%20adult%20zebrafish%20model%20of%20Parkinson%E2%80%99s%20disease_Scopus.pdf
http://irep.iium.edu.my/114376/
https://doi.org/10.3389/fnins.2024.1432102
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spelling my.iium.irep.1143762024-10-07T06:03:08Z http://irep.iium.edu.my/114376/ Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration Razali, Khairiah Kumar, Jaya Mohamed, Wael Mohamed Yousef R Medicine (General) Introduction: Adult zebrafish are increasingly used in Parkinson’s disease (PD) research due to their well-characterized dopaminergic system. Among the toxin-based models, the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely utilized to induce parkinsonism in adult zebrafish. Therefore, this review presents an overview of the procedures and the dynamic changes in behavior and physiology observed in the adult zebrafish PD model following a single intraperitoneal injection of MPTP. Methods: A systematic literature search in the PubMed and Google Scholar databases was conducted to identify relevant articles. Of the 165 articles identified, 9 were included in this review. These chosen articles are original works published before March 2024, all of which utilized adult zebrafish induced with MPTP as the model for PD. Other articles were excluded based on factors such as limited relevance, utilization of zebrafish embryos or larvae instead of adults, and variations in MPTP deliveries. Results: Studies indicated that the ideal model entails the utilization of mixed gender zebrafish aged between 4 and 6 months from the wild-type strain. The acceptable MPTP doses ranges between 20 μg/g (lowest) and 225 μg/g (highest) and doses above 292 μg/g are lethal. Furthermore, noticeable parkinsonian symptoms appear 1 day after administration and persist for more than 1 week. Discussion: Mitochondrial dysfunction precedes dopaminergic neurodegeneration within this experimental regime. A single administration of MPTP effectively induces PD in adult zebrafish. This study aids in crafting the adult zebrafish PD model, outlining the progressive behavioral and physiological changes ensuing from MPTP administration. Frontiers 2024-09-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/114376/7/114376_Characterizing%20the%20adult%20zebrafish%20model%20of%20Parkinson%E2%80%99s%20disease.pdf application/pdf en http://irep.iium.edu.my/114376/13/114376_Characterizing%20the%20adult%20zebrafish%20model%20of%20Parkinson%E2%80%99s%20disease_Scopus.pdf Razali, Khairiah and Kumar, Jaya and Mohamed, Wael Mohamed Yousef (2024) Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration. Frontiers in Neuroscience, 18. ISSN 1662-4548 E-ISSN 1662-453X https://doi.org/10.3389/fnins.2024.1432102
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Razali, Khairiah
Kumar, Jaya
Mohamed, Wael Mohamed Yousef
Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration
description Introduction: Adult zebrafish are increasingly used in Parkinson’s disease (PD) research due to their well-characterized dopaminergic system. Among the toxin-based models, the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely utilized to induce parkinsonism in adult zebrafish. Therefore, this review presents an overview of the procedures and the dynamic changes in behavior and physiology observed in the adult zebrafish PD model following a single intraperitoneal injection of MPTP. Methods: A systematic literature search in the PubMed and Google Scholar databases was conducted to identify relevant articles. Of the 165 articles identified, 9 were included in this review. These chosen articles are original works published before March 2024, all of which utilized adult zebrafish induced with MPTP as the model for PD. Other articles were excluded based on factors such as limited relevance, utilization of zebrafish embryos or larvae instead of adults, and variations in MPTP deliveries. Results: Studies indicated that the ideal model entails the utilization of mixed gender zebrafish aged between 4 and 6 months from the wild-type strain. The acceptable MPTP doses ranges between 20 μg/g (lowest) and 225 μg/g (highest) and doses above 292 μg/g are lethal. Furthermore, noticeable parkinsonian symptoms appear 1 day after administration and persist for more than 1 week. Discussion: Mitochondrial dysfunction precedes dopaminergic neurodegeneration within this experimental regime. A single administration of MPTP effectively induces PD in adult zebrafish. This study aids in crafting the adult zebrafish PD model, outlining the progressive behavioral and physiological changes ensuing from MPTP administration.
format Article
author Razali, Khairiah
Kumar, Jaya
Mohamed, Wael Mohamed Yousef
author_facet Razali, Khairiah
Kumar, Jaya
Mohamed, Wael Mohamed Yousef
author_sort Razali, Khairiah
title Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration
title_short Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration
title_full Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration
title_fullStr Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration
title_full_unstemmed Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration
title_sort characterizing the adult zebrafish model of parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-mptp administration
publisher Frontiers
publishDate 2024
url http://irep.iium.edu.my/114376/7/114376_Characterizing%20the%20adult%20zebrafish%20model%20of%20Parkinson%E2%80%99s%20disease.pdf
http://irep.iium.edu.my/114376/13/114376_Characterizing%20the%20adult%20zebrafish%20model%20of%20Parkinson%E2%80%99s%20disease_Scopus.pdf
http://irep.iium.edu.my/114376/
https://doi.org/10.3389/fnins.2024.1432102
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score 13.211869

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