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Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli

A large body of research establishes the efficacy of musical intervention in many aspects of physical, cognitive, communication, social, and emotional rehabilitation. However, the underlying neural mechanisms for musical therapy remain elusive. This study aimed to investigate the potential neural co...

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Main Authors:	Mohd Rashid, Muhammad Hakimi, Ab Rani, Nur Syairah, Kannan, Mohammed, Abdullah, Mohd Waqiyuddin, Ab Ghani, Muhammad Amiri, Kamel, Nidal, Mustapha, Muzaimi
Format:	Article
Language:	English English
Published:	PeerJ Inc. 2024
Subjects:	RA790 Mental Health. Mental Illness Prevention RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RZ400 Mental healing
Online Access:	http://irep.iium.edu.my/114208/2/114208_Emotion%20brain%20network%20topology%20in%20healthy%20subjects_SCOPUS.pdf http://irep.iium.edu.my/114208/3/114208_Emotion%20brain%20network%20topology%20in%20healthy%20subjects.pdf http://irep.iium.edu.my/114208/ https://peerj.com/articles/17721.pdf https://doi.org/10.7717/peerj.17721
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spelling	my.iium.irep.1142082024-09-03T06:34:00Z http://irep.iium.edu.my/114208/ Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli Mohd Rashid, Muhammad Hakimi Ab Rani, Nur Syairah Kannan, Mohammed Abdullah, Mohd Waqiyuddin Ab Ghani, Muhammad Amiri Kamel, Nidal Mustapha, Muzaimi RA790 Mental Health. Mental Illness Prevention RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RZ400 Mental healing A large body of research establishes the efficacy of musical intervention in many aspects of physical, cognitive, communication, social, and emotional rehabilitation. However, the underlying neural mechanisms for musical therapy remain elusive. This study aimed to investigate the potential neural correlates of musical therapy, focusing on the changes in the topology of emotion brain network. To this end, a Bayesian statistical approach and a cross-over experimental design were employed together with two resting-state magnetoencephalography (MEG) as controls. MEG recordings of 30 healthy subjects were acquired while listening to five auditory stimuli in random order. Two resting-state MEG recordings of each subject were obtained, one prior to the first stimulus (pre) and one after the final stimulus (post). Time series at the level of brain regions were estimated using depth-weighted minimum norm estimation (wMNE) source reconstruction method and the functional connectivity between these regions were computed. The resultant connectivity matrices were used to derive two topological network measures: transitivity and global efficiency which are important in gauging the functional segregation and integration of brain network respectively. The differences in these measures between pre- and post-stimuli resting MEG were set as the equivalence regions. We found that the network measures under all auditory stimuli were equivalent to the resting state network measures in all frequency bands, indicating that the topology of the functional brain network associated with emotional regulation in healthy subjects remains unchanged following these auditory stimuli. This suggests that changes in the emotion network topology may not be the underlying neural mechanism of musical therapy. Nonetheless, further studies are required to explore the neural mechanisms of musical interventions especially in the populations with neuropsychiatric disorders. PeerJ Inc. 2024-07-19 Article PeerReviewed application/pdf en http://irep.iium.edu.my/114208/2/114208_Emotion%20brain%20network%20topology%20in%20healthy%20subjects_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/114208/3/114208_Emotion%20brain%20network%20topology%20in%20healthy%20subjects.pdf Mohd Rashid, Muhammad Hakimi and Ab Rani, Nur Syairah and Kannan, Mohammed and Abdullah, Mohd Waqiyuddin and Ab Ghani, Muhammad Amiri and Kamel, Nidal and Mustapha, Muzaimi (2024) Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli. PeerJ, 12 (7). pp. 1-34. ISSN 2167-8359 https://peerj.com/articles/17721.pdf https://doi.org/10.7717/peerj.17721
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	RA790 Mental Health. Mental Illness Prevention RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RZ400 Mental healing
spellingShingle	RA790 Mental Health. Mental Illness Prevention RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RZ400 Mental healing Mohd Rashid, Muhammad Hakimi Ab Rani, Nur Syairah Kannan, Mohammed Abdullah, Mohd Waqiyuddin Ab Ghani, Muhammad Amiri Kamel, Nidal Mustapha, Muzaimi Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli
description	A large body of research establishes the efficacy of musical intervention in many aspects of physical, cognitive, communication, social, and emotional rehabilitation. However, the underlying neural mechanisms for musical therapy remain elusive. This study aimed to investigate the potential neural correlates of musical therapy, focusing on the changes in the topology of emotion brain network. To this end, a Bayesian statistical approach and a cross-over experimental design were employed together with two resting-state magnetoencephalography (MEG) as controls. MEG recordings of 30 healthy subjects were acquired while listening to five auditory stimuli in random order. Two resting-state MEG recordings of each subject were obtained, one prior to the first stimulus (pre) and one after the final stimulus (post). Time series at the level of brain regions were estimated using depth-weighted minimum norm estimation (wMNE) source reconstruction method and the functional connectivity between these regions were computed. The resultant connectivity matrices were used to derive two topological network measures: transitivity and global efficiency which are important in gauging the functional segregation and integration of brain network respectively. The differences in these measures between pre- and post-stimuli resting MEG were set as the equivalence regions. We found that the network measures under all auditory stimuli were equivalent to the resting state network measures in all frequency bands, indicating that the topology of the functional brain network associated with emotional regulation in healthy subjects remains unchanged following these auditory stimuli. This suggests that changes in the emotion network topology may not be the underlying neural mechanism of musical therapy. Nonetheless, further studies are required to explore the neural mechanisms of musical interventions especially in the populations with neuropsychiatric disorders.
format	Article
author	Mohd Rashid, Muhammad Hakimi Ab Rani, Nur Syairah Kannan, Mohammed Abdullah, Mohd Waqiyuddin Ab Ghani, Muhammad Amiri Kamel, Nidal Mustapha, Muzaimi
author_facet	Mohd Rashid, Muhammad Hakimi Ab Rani, Nur Syairah Kannan, Mohammed Abdullah, Mohd Waqiyuddin Ab Ghani, Muhammad Amiri Kamel, Nidal Mustapha, Muzaimi
author_sort	Mohd Rashid, Muhammad Hakimi
title	Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli
title_short	Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli
title_full	Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli
title_fullStr	Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli
title_full_unstemmed	Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli
title_sort	emotion brain network topology in healthy subjects following passive listening to different auditory stimuli
publisher	PeerJ Inc.
publishDate	2024
url	http://irep.iium.edu.my/114208/2/114208_Emotion%20brain%20network%20topology%20in%20healthy%20subjects_SCOPUS.pdf http://irep.iium.edu.my/114208/3/114208_Emotion%20brain%20network%20topology%20in%20healthy%20subjects.pdf http://irep.iium.edu.my/114208/ https://peerj.com/articles/17721.pdf https://doi.org/10.7717/peerj.17721
_version_	1811679619574661120
score	13.211869

Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli

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