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Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel

Syzygium cumini is a traditional medicinal plant that has been used to treat various ailments. This study is conducted to characterise the extract contents, rheological, release, and texture profile of Syzygium cumini gel to be developed as anti- mucositis gel for dental applications. To determi...

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Main Authors: Sukmasari, Susi, Abdul Rahman, Mohammad Nasrin, Doolaanea, Abd Almonem, Arzmi, Mohd Hafiz, Mezan, Nur Zakirah, Mohammad Muzafar Shah, Azyyati, Maghzan, Putri Izz Khayrin
Format: Article
Language:English
English
Published: Sami Publishing Company 2024
Subjects:
QR Microbiology
RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:http://irep.iium.edu.my/113856/1/113856_Elucidation%20profile%20analysis%20syzygium%20cumini.pdf
http://irep.iium.edu.my/113856/7/113856_Elucidation%20profile%20analysis%20syzygium%20cumini_SCOPUS.pdf
http://irep.iium.edu.my/113856/
https://jmpcr.samipubco.com/article_198069.html
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spelling my.iium.irep.1138562024-09-24T09:23:09Z http://irep.iium.edu.my/113856/ Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel Sukmasari, Susi Abdul Rahman, Mohammad Nasrin Doolaanea, Abd Almonem Arzmi, Mohd Hafiz Mezan, Nur Zakirah Mohammad Muzafar Shah, Azyyati Maghzan, Putri Izz Khayrin QR Microbiology RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works RM Therapeutics. Pharmacology RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Syzygium cumini is a traditional medicinal plant that has been used to treat various ailments. This study is conducted to characterise the extract contents, rheological, release, and texture profile of Syzygium cumini gel to be developed as anti- mucositis gel for dental applications. To determine the phytochemical content, Supercritical Fluid Extraction, and Soxhlet extractions were conducted. Whereas rheological characterisation, release, and texture profiles of five different gels were formulated using SC leaves extracted using sequential cold percolation (toluene, petroleum ether, acetyl acetate, acetone, and water extract). The rheological, release and texture profiles of the gels were then measured using rheometer, incubator shaker, and texture analyser, respectively. It was found that SC leaves extracted using Soxhlet contains the highest total phenolic and catechin content, while epicatechin content was highest in the extract of Supercritical Fluid Extraction with carbon dioxide as solvent at 150 bar. Regarding the gels, water extract gel had the best rheological profile. Although water extract had low permeability coefficient based on the release profile test, there was statistically significance difference in term of permeation rate flux from other gels (P<0.05). Phytochemical content and other related data were successfully documented to help in elucidating the best dental gel to be developed as antimucositis gel. Sami Publishing Company 2024-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/113856/1/113856_Elucidation%20profile%20analysis%20syzygium%20cumini.pdf application/pdf en http://irep.iium.edu.my/113856/7/113856_Elucidation%20profile%20analysis%20syzygium%20cumini_SCOPUS.pdf Sukmasari, Susi and Abdul Rahman, Mohammad Nasrin and Doolaanea, Abd Almonem and Arzmi, Mohd Hafiz and Mezan, Nur Zakirah and Mohammad Muzafar Shah, Azyyati and Maghzan, Putri Izz Khayrin (2024) Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel. Journal of Medicinal and Pharmaceutical Chemistry Research, 6 (12). pp. 1888-1904. ISSN 2981-0221 E-ISSN 2981-0213 https://jmpcr.samipubco.com/article_198069.html 10.48309/jmpcr.2024.450357.1163
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QR Microbiology
RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle QR Microbiology
RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS403 Materia Medica-Pharmaceutical Chemistry
Sukmasari, Susi
Abdul Rahman, Mohammad Nasrin
Doolaanea, Abd Almonem
Arzmi, Mohd Hafiz
Mezan, Nur Zakirah
Mohammad Muzafar Shah, Azyyati
Maghzan, Putri Izz Khayrin
Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel
description Syzygium cumini is a traditional medicinal plant that has been used to treat various ailments. This study is conducted to characterise the extract contents, rheological, release, and texture profile of Syzygium cumini gel to be developed as anti- mucositis gel for dental applications. To determine the phytochemical content, Supercritical Fluid Extraction, and Soxhlet extractions were conducted. Whereas rheological characterisation, release, and texture profiles of five different gels were formulated using SC leaves extracted using sequential cold percolation (toluene, petroleum ether, acetyl acetate, acetone, and water extract). The rheological, release and texture profiles of the gels were then measured using rheometer, incubator shaker, and texture analyser, respectively. It was found that SC leaves extracted using Soxhlet contains the highest total phenolic and catechin content, while epicatechin content was highest in the extract of Supercritical Fluid Extraction with carbon dioxide as solvent at 150 bar. Regarding the gels, water extract gel had the best rheological profile. Although water extract had low permeability coefficient based on the release profile test, there was statistically significance difference in term of permeation rate flux from other gels (P<0.05). Phytochemical content and other related data were successfully documented to help in elucidating the best dental gel to be developed as antimucositis gel.
format Article
author Sukmasari, Susi
Abdul Rahman, Mohammad Nasrin
Doolaanea, Abd Almonem
Arzmi, Mohd Hafiz
Mezan, Nur Zakirah
Mohammad Muzafar Shah, Azyyati
Maghzan, Putri Izz Khayrin
author_facet Sukmasari, Susi
Abdul Rahman, Mohammad Nasrin
Doolaanea, Abd Almonem
Arzmi, Mohd Hafiz
Mezan, Nur Zakirah
Mohammad Muzafar Shah, Azyyati
Maghzan, Putri Izz Khayrin
author_sort Sukmasari, Susi
title Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel
title_short Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel
title_full Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel
title_fullStr Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel
title_full_unstemmed Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel
title_sort elucidation profile analysis syzygium cumini extract to be developed as oral anti-mucositis gel
publisher Sami Publishing Company
publishDate 2024
url http://irep.iium.edu.my/113856/1/113856_Elucidation%20profile%20analysis%20syzygium%20cumini.pdf
http://irep.iium.edu.my/113856/7/113856_Elucidation%20profile%20analysis%20syzygium%20cumini_SCOPUS.pdf
http://irep.iium.edu.my/113856/
https://jmpcr.samipubco.com/article_198069.html
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score 13.211869

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