Staff View: Advancements of gene therapy in cancer treatment: a comprehensive review

Advancements of gene therapy in cancer treatment: a comprehensive review

Cancer is the main contributor for mortality in the world. Conventional therapy that available as the treatment options are chemotherapy, radiotherapy and surgery. However, these treatments are hardly cell-specific most of the time. Nowadays, extensive research and investigations are made to develop...

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Main Authors:	Mohd Abas, Muhammad Dhiyauddin, Mohd Asri, Muhammad Fareez, Yusafawi, Nur Anis Suffiah, Rosman, Nur Anis Zahra, Baharudin, Nur Arifah Zahidah, Bakhtiar, M Taher, Darnis, Deny Susanti, Khotib, Junaidi
Format:	Article
Language:	English English
Published:	Elsevier 2024
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/113785/1/113785_Advancement%20of%20gene%20therapy%20in%20cancer%20treatment.pdf http://irep.iium.edu.my/113785/7/113785_Advancement%20of%20gene%20therapy%20in%20cancer%20treatment_SCOPUS.pdf http://irep.iium.edu.my/113785/ https://www.sciencedirect.com/science/article/abs/pii/S0344033824004205
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spelling	my.iium.irep.1137852024-08-16T13:41:13Z http://irep.iium.edu.my/113785/ Advancements of gene therapy in cancer treatment: a comprehensive review Mohd Abas, Muhammad Dhiyauddin Mohd Asri, Muhammad Fareez Yusafawi, Nur Anis Suffiah Rosman, Nur Anis Zahra Baharudin, Nur Arifah Zahidah Bakhtiar, M Taher Darnis, Deny Susanti Khotib, Junaidi RS Pharmacy and materia medica Cancer is the main contributor for mortality in the world. Conventional therapy that available as the treatment options are chemotherapy, radiotherapy and surgery. However, these treatments are hardly cell-specific most of the time. Nowadays, extensive research and investigations are made to develop cell-specific approaches prior to cancer treatment. Some of them are photodynamic therapy, hyperthermia, immunotherapy, stem cell trans- plantation and targeted therapy. This review article will be focusing on the development of gene therapy in cancer. The objective of gene therapy is to correct specific mutant genes causing the excessive proliferation of the cell that leads to cancer. There are lots of explorations in the approach to modify the gene. The delivery of this therapy plays a big role in its success. If the inserted gene does not find its way to the target, the therapy is considered a failure. Hence, vectors are needed and the common vectors used are viral, non viral or synthetic, polymer based and lipid based vectors. The advancement of gene therapy in cancer treatment will be focussing on the top three cancer cases in the world which are breast, lung and colon cancer. In breast cancer, the discussed therapy are CRISPR/Cas9, siRNA and gene silencing whereas in colon cancer miRNA and suicide gene therapy and in lung cancer, replacement of tumor suppressor gene, CRISPR/Cas9 and miRNA. Elsevier 2024-08-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/113785/1/113785_Advancement%20of%20gene%20therapy%20in%20cancer%20treatment.pdf application/pdf en http://irep.iium.edu.my/113785/7/113785_Advancement%20of%20gene%20therapy%20in%20cancer%20treatment_SCOPUS.pdf Mohd Abas, Muhammad Dhiyauddin and Mohd Asri, Muhammad Fareez and Yusafawi, Nur Anis Suffiah and Rosman, Nur Anis Zahra and Baharudin, Nur Arifah Zahidah and Bakhtiar, M Taher and Darnis, Deny Susanti and Khotib, Junaidi (2024) Advancements of gene therapy in cancer treatment: a comprehensive review. Pathology Research and Practice, 261. pp. 1-11. ISSN 0344-0338 E-ISSN 1618-0631 https://www.sciencedirect.com/science/article/abs/pii/S0344033824004205 10.1016/j.prp.2024.155509
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohd Abas, Muhammad Dhiyauddin Mohd Asri, Muhammad Fareez Yusafawi, Nur Anis Suffiah Rosman, Nur Anis Zahra Baharudin, Nur Arifah Zahidah Bakhtiar, M Taher Darnis, Deny Susanti Khotib, Junaidi Advancements of gene therapy in cancer treatment: a comprehensive review
description	Cancer is the main contributor for mortality in the world. Conventional therapy that available as the treatment options are chemotherapy, radiotherapy and surgery. However, these treatments are hardly cell-specific most of the time. Nowadays, extensive research and investigations are made to develop cell-specific approaches prior to cancer treatment. Some of them are photodynamic therapy, hyperthermia, immunotherapy, stem cell trans- plantation and targeted therapy. This review article will be focusing on the development of gene therapy in cancer. The objective of gene therapy is to correct specific mutant genes causing the excessive proliferation of the cell that leads to cancer. There are lots of explorations in the approach to modify the gene. The delivery of this therapy plays a big role in its success. If the inserted gene does not find its way to the target, the therapy is considered a failure. Hence, vectors are needed and the common vectors used are viral, non viral or synthetic, polymer based and lipid based vectors. The advancement of gene therapy in cancer treatment will be focussing on the top three cancer cases in the world which are breast, lung and colon cancer. In breast cancer, the discussed therapy are CRISPR/Cas9, siRNA and gene silencing whereas in colon cancer miRNA and suicide gene therapy and in lung cancer, replacement of tumor suppressor gene, CRISPR/Cas9 and miRNA.
format	Article
author	Mohd Abas, Muhammad Dhiyauddin Mohd Asri, Muhammad Fareez Yusafawi, Nur Anis Suffiah Rosman, Nur Anis Zahra Baharudin, Nur Arifah Zahidah Bakhtiar, M Taher Darnis, Deny Susanti Khotib, Junaidi
author_facet	Mohd Abas, Muhammad Dhiyauddin Mohd Asri, Muhammad Fareez Yusafawi, Nur Anis Suffiah Rosman, Nur Anis Zahra Baharudin, Nur Arifah Zahidah Bakhtiar, M Taher Darnis, Deny Susanti Khotib, Junaidi
author_sort	Mohd Abas, Muhammad Dhiyauddin
title	Advancements of gene therapy in cancer treatment: a comprehensive review
title_short	Advancements of gene therapy in cancer treatment: a comprehensive review
title_full	Advancements of gene therapy in cancer treatment: a comprehensive review
title_fullStr	Advancements of gene therapy in cancer treatment: a comprehensive review
title_full_unstemmed	Advancements of gene therapy in cancer treatment: a comprehensive review
title_sort	advancements of gene therapy in cancer treatment: a comprehensive review
publisher	Elsevier
publishDate	2024
url	http://irep.iium.edu.my/113785/1/113785_Advancement%20of%20gene%20therapy%20in%20cancer%20treatment.pdf http://irep.iium.edu.my/113785/7/113785_Advancement%20of%20gene%20therapy%20in%20cancer%20treatment_SCOPUS.pdf http://irep.iium.edu.my/113785/ https://www.sciencedirect.com/science/article/abs/pii/S0344033824004205
_version_	1809136354289778688
score	13.211869

Advancements of gene therapy in cancer treatment: a comprehensive review

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