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Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models

INTRODUCTION: Osteoarthritis (OA) is a prevalent degenerative joint disease with significant global impact. Honey has shown therapeutic potential in treating OA1. This study aims to evaluate the therapeutic potential of Tualang Honey Formulation (THF) in the management of OA using a New Zealand Whit...

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Main Authors: Mohamad Amri, Nur Fathonah, Abd. Rahim, Nour El Huda, Zulkifly, Ahmad Hafiz, Hassan, Habibah, Mohd Jan, Nurul Hafiza, Ibrahim, Mohd Zulfadzli
Format: Article
Language:English
Published: Malaysian Orthopaedic Association 2024
Subjects:
R Medicine (General)
RD Surgery
RD701 Orthopedics
Online Access:http://irep.iium.edu.my/113205/9/113205_Therapeutic%20potential%20of%20Tualang%20honey%20formulation%20in%20osteoarthritis.pdf
http://irep.iium.edu.my/113205/
https://www.morthoj.org/supplements/moa-2024/Poster/Ortho-Research/ER02.pdf
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spelling my.iium.irep.1132052024-12-04T00:00:30Z http://irep.iium.edu.my/113205/ Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models Mohamad Amri, Nur Fathonah Abd. Rahim, Nour El Huda Zulkifly, Ahmad Hafiz Hassan, Habibah Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli R Medicine (General) RD Surgery RD701 Orthopedics INTRODUCTION: Osteoarthritis (OA) is a prevalent degenerative joint disease with significant global impact. Honey has shown therapeutic potential in treating OA1. This study aims to evaluate the therapeutic potential of Tualang Honey Formulation (THF) in the management of OA using a New Zealand White Rabbit (NZWR) model, in comparison to the control group. MATERIALS & METHODS: A controlled experiment was conducted with sixteen NZWR, surgically induced to develop OA. The experimental group received THF intraarticularly after 3 weeks post-surgery, while control group did not receive any treatment. The rabbits were then euthanized and x-rays were taken at 3, 6, 12, and 24 weeks to evaluate joint space narrowing and subchondral sclerosis as indicators of OA progression. RESULTS: Radiographic analysis showed that rabbits treated with THF exhibited less joint space narrowing and subchondral sclerosis compared to the control group. Notable radiological improvements were evident from the 6-week mark, indicating a slower progression of OA. DISCUSSIONS: THF appears to improve the radiographic progression of OA, suggesting its potential as a therapeutic agent2. Its effects on subchondral sclerosis and joint space preservation suggest its beneficial effects on joint health. CONCLUSION: THF demonstrates radiographic and potential benefits in OA management in NZWR. Further research is warranted to understand its therapeutic mechanisms. Malaysian Orthopaedic Association 2024-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/113205/9/113205_Therapeutic%20potential%20of%20Tualang%20honey%20formulation%20in%20osteoarthritis.pdf Mohamad Amri, Nur Fathonah and Abd. Rahim, Nour El Huda and Zulkifly, Ahmad Hafiz and Hassan, Habibah and Mohd Jan, Nurul Hafiza and Ibrahim, Mohd Zulfadzli (2024) Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models. Malaysian Orthopaedic Journal, 17 (Suppl. A). ISSN 1985-2533 E-ISSN 2232-111X https://www.morthoj.org/supplements/moa-2024/Poster/Ortho-Research/ER02.pdf
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RD Surgery
RD701 Orthopedics
spellingShingle R Medicine (General)
RD Surgery
RD701 Orthopedics
Mohamad Amri, Nur Fathonah
Abd. Rahim, Nour El Huda
Zulkifly, Ahmad Hafiz
Hassan, Habibah
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models
description INTRODUCTION: Osteoarthritis (OA) is a prevalent degenerative joint disease with significant global impact. Honey has shown therapeutic potential in treating OA1. This study aims to evaluate the therapeutic potential of Tualang Honey Formulation (THF) in the management of OA using a New Zealand White Rabbit (NZWR) model, in comparison to the control group. MATERIALS & METHODS: A controlled experiment was conducted with sixteen NZWR, surgically induced to develop OA. The experimental group received THF intraarticularly after 3 weeks post-surgery, while control group did not receive any treatment. The rabbits were then euthanized and x-rays were taken at 3, 6, 12, and 24 weeks to evaluate joint space narrowing and subchondral sclerosis as indicators of OA progression. RESULTS: Radiographic analysis showed that rabbits treated with THF exhibited less joint space narrowing and subchondral sclerosis compared to the control group. Notable radiological improvements were evident from the 6-week mark, indicating a slower progression of OA. DISCUSSIONS: THF appears to improve the radiographic progression of OA, suggesting its potential as a therapeutic agent2. Its effects on subchondral sclerosis and joint space preservation suggest its beneficial effects on joint health. CONCLUSION: THF demonstrates radiographic and potential benefits in OA management in NZWR. Further research is warranted to understand its therapeutic mechanisms.
format Article
author Mohamad Amri, Nur Fathonah
Abd. Rahim, Nour El Huda
Zulkifly, Ahmad Hafiz
Hassan, Habibah
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
author_facet Mohamad Amri, Nur Fathonah
Abd. Rahim, Nour El Huda
Zulkifly, Ahmad Hafiz
Hassan, Habibah
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
author_sort Mohamad Amri, Nur Fathonah
title Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models
title_short Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models
title_full Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models
title_fullStr Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models
title_full_unstemmed Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models
title_sort therapeutic potential of tualang honey formulation in osteoarthritis: a comparative study in new zealand white rabbit models
publisher Malaysian Orthopaedic Association
publishDate 2024
url http://irep.iium.edu.my/113205/9/113205_Therapeutic%20potential%20of%20Tualang%20honey%20formulation%20in%20osteoarthritis.pdf
http://irep.iium.edu.my/113205/
https://www.morthoj.org/supplements/moa-2024/Poster/Ortho-Research/ER02.pdf
_version_ 1817841069033783296
score 13.235796

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