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Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults

Introduction: Uncontrolled hypertension is a primary risk factor for premature coronary artery disease (CAD) in young adults. The risk of CAD among young hypertensive adults is commonly underestimated owing to the young age. Hence, identification of novel biomarker(s) to improve risk stratification...

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Main Authors: Mohamed Bakrim, Norbaiyah, Wan Omar, Wan Fatein Nabeila, Abdullah, Aszrin, Hamidon, Nurul Nadiah, Abdul Muid, Suhaila, Badrulhisham, Aisyah
Format: Article
Language:English
English
Published: IIUM Press 2024
Subjects:
QP Physiology
Online Access:http://irep.iium.edu.my/110348/13/110348_Plasma%20haptoglobin%20as%20a%20potential%20biomarker.pdf
http://irep.iium.edu.my/110348/19/110348_Plasma%20haptoglobin%20as%20a%20potential%20biomarker_SCOPUS.pdf
http://irep.iium.edu.my/110348/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/2371/1460
https://journals.iium.edu.my/kom/index.php/imjm/issue/view/54
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spelling my.iium.irep.1103482024-05-23T07:12:47Z http://irep.iium.edu.my/110348/ Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults Mohamed Bakrim, Norbaiyah Wan Omar, Wan Fatein Nabeila Abdullah, Aszrin Hamidon, Nurul Nadiah Abdul Muid, Suhaila Badrulhisham, Aisyah QP Physiology Introduction: Uncontrolled hypertension is a primary risk factor for premature coronary artery disease (CAD) in young adults. The risk of CAD among young hypertensive adults is commonly underestimated owing to the young age. Hence, identification of novel biomarker(s) to improve risk stratification of CAD in young hypertensive adults is essential for more accurate CAD risk assessment and thus to improve management of hypertension in this cohort. This study investigated plasma haptoglobin concentration in young adults with acute myocardial infarction (AMI) and hypertension to evaluate the potential of haptoglobin as a biomarker in the establishment of CAD in young hypertensive adults. Materials and Methods: A total of 120 male young adults aged between 18 to 45 years were enrolled in this cross-sectional study (40 subjects in control, hypertensive and AMI group respectively). Blood samples were collected from all subjects. Plasma concentrations of haptoglobin was measured using enzyme-linked immunosorbent assays. Other CAD risk factors including high sensitivity C-reactive protein (hs-CRP) levels were analyzed. Results: Plasma concentration of haptoglobin in the AMI group was the highest as compared to hypertensive and control group (290.63±99.90 vs. 208.47±112.93 vs. 170.02±108.11 ng/ml, p<0.006). There was a significant association between AMI and plasma haptoglobin concentration in hypertensive subjects independent of other known CAD risk factors (OR: 0.985, 95% CI 0.973-0.997, p=0.017). There was positive correlation between plasma haptoglobin and hs-CRP (r=0.0370, p<0.001). Conclusion: Plasma haptoglobin is a potential biomarker to identify young hypertensive adults who are at risk of developing CAD. (246 words) IIUM Press 2024-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/110348/13/110348_Plasma%20haptoglobin%20as%20a%20potential%20biomarker.pdf application/pdf en http://irep.iium.edu.my/110348/19/110348_Plasma%20haptoglobin%20as%20a%20potential%20biomarker_SCOPUS.pdf Mohamed Bakrim, Norbaiyah and Wan Omar, Wan Fatein Nabeila and Abdullah, Aszrin and Hamidon, Nurul Nadiah and Abdul Muid, Suhaila and Badrulhisham, Aisyah (2024) Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults. IIUM Medical Journal Malaysia, 23 (1). pp. 115-122. ISSN 1823-4631 E-ISSN 2735-2285 https://journals.iium.edu.my/kom/index.php/imjm/article/view/2371/1460 https://journals.iium.edu.my/kom/index.php/imjm/issue/view/54
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QP Physiology
spellingShingle QP Physiology
Mohamed Bakrim, Norbaiyah
Wan Omar, Wan Fatein Nabeila
Abdullah, Aszrin
Hamidon, Nurul Nadiah
Abdul Muid, Suhaila
Badrulhisham, Aisyah
Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults
description Introduction: Uncontrolled hypertension is a primary risk factor for premature coronary artery disease (CAD) in young adults. The risk of CAD among young hypertensive adults is commonly underestimated owing to the young age. Hence, identification of novel biomarker(s) to improve risk stratification of CAD in young hypertensive adults is essential for more accurate CAD risk assessment and thus to improve management of hypertension in this cohort. This study investigated plasma haptoglobin concentration in young adults with acute myocardial infarction (AMI) and hypertension to evaluate the potential of haptoglobin as a biomarker in the establishment of CAD in young hypertensive adults. Materials and Methods: A total of 120 male young adults aged between 18 to 45 years were enrolled in this cross-sectional study (40 subjects in control, hypertensive and AMI group respectively). Blood samples were collected from all subjects. Plasma concentrations of haptoglobin was measured using enzyme-linked immunosorbent assays. Other CAD risk factors including high sensitivity C-reactive protein (hs-CRP) levels were analyzed. Results: Plasma concentration of haptoglobin in the AMI group was the highest as compared to hypertensive and control group (290.63±99.90 vs. 208.47±112.93 vs. 170.02±108.11 ng/ml, p<0.006). There was a significant association between AMI and plasma haptoglobin concentration in hypertensive subjects independent of other known CAD risk factors (OR: 0.985, 95% CI 0.973-0.997, p=0.017). There was positive correlation between plasma haptoglobin and hs-CRP (r=0.0370, p<0.001). Conclusion: Plasma haptoglobin is a potential biomarker to identify young hypertensive adults who are at risk of developing CAD. (246 words)
format Article
author Mohamed Bakrim, Norbaiyah
Wan Omar, Wan Fatein Nabeila
Abdullah, Aszrin
Hamidon, Nurul Nadiah
Abdul Muid, Suhaila
Badrulhisham, Aisyah
author_facet Mohamed Bakrim, Norbaiyah
Wan Omar, Wan Fatein Nabeila
Abdullah, Aszrin
Hamidon, Nurul Nadiah
Abdul Muid, Suhaila
Badrulhisham, Aisyah
author_sort Mohamed Bakrim, Norbaiyah
title Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults
title_short Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults
title_full Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults
title_fullStr Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults
title_full_unstemmed Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults
title_sort plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults
publisher IIUM Press
publishDate 2024
url http://irep.iium.edu.my/110348/13/110348_Plasma%20haptoglobin%20as%20a%20potential%20biomarker.pdf
http://irep.iium.edu.my/110348/19/110348_Plasma%20haptoglobin%20as%20a%20potential%20biomarker_SCOPUS.pdf
http://irep.iium.edu.my/110348/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/2371/1460
https://journals.iium.edu.my/kom/index.php/imjm/issue/view/54
_version_ 1800082022574587904
score 13.211869

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