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Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson's disease with 49,049...

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Main Authors: Kim, Jonggeol Jeffrey, Cornelis, Blauwendraat, Vitale, Dan, Mohamed, Wael Mohamed Yousef
Format: Article
Language:English
English
English
Published: Springer Nature 2024
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/110051/18/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%27s%20disease.pdf
http://irep.iium.edu.my/110051/7/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%E2%80%99s%20disease_Scopus.pdf
http://irep.iium.edu.my/110051/13/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%E2%80%99s%20disease_Scopus_1.pdf
http://irep.iium.edu.my/110051/
https://www.nature.com/articles/s41588-023-01584-8
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spelling my.iium.irep.1100512024-08-26T07:09:12Z http://irep.iium.edu.my/110051/ Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease Kim, Jonggeol Jeffrey Cornelis, Blauwendraat Vitale, Dan Mohamed, Wael Mohamed Yousef R Medicine (General) Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson's disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations. Springer Nature 2024-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/110051/18/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%27s%20disease.pdf application/pdf en http://irep.iium.edu.my/110051/7/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%E2%80%99s%20disease_Scopus.pdf application/pdf en http://irep.iium.edu.my/110051/13/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%E2%80%99s%20disease_Scopus_1.pdf Kim, Jonggeol Jeffrey and Cornelis, Blauwendraat and Vitale, Dan and Mohamed, Wael Mohamed Yousef (2024) Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease. Nature Genetics, 56 (1). pp. 27-36. ISSN 1061-4036 E-ISSN 1546-1718 https://www.nature.com/articles/s41588-023-01584-8 10.1038/s41588-023-01584-8
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Kim, Jonggeol Jeffrey
Cornelis, Blauwendraat
Vitale, Dan
Mohamed, Wael Mohamed Yousef
Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
description Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson's disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations.
format Article
author Kim, Jonggeol Jeffrey
Cornelis, Blauwendraat
Vitale, Dan
Mohamed, Wael Mohamed Yousef
author_facet Kim, Jonggeol Jeffrey
Cornelis, Blauwendraat
Vitale, Dan
Mohamed, Wael Mohamed Yousef
author_sort Kim, Jonggeol Jeffrey
title Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
title_short Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
title_full Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
title_fullStr Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
title_full_unstemmed Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
title_sort multi-ancestry genome-wide association meta-analysis of parkinson’s disease
publisher Springer Nature
publishDate 2024
url http://irep.iium.edu.my/110051/18/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%27s%20disease.pdf
http://irep.iium.edu.my/110051/7/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%E2%80%99s%20disease_Scopus.pdf
http://irep.iium.edu.my/110051/13/110051_Multi-ancestry%20genome-wide%20association%20meta-analysis%20of%20Parkinson%E2%80%99s%20disease_Scopus_1.pdf
http://irep.iium.edu.my/110051/
https://www.nature.com/articles/s41588-023-01584-8
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