Staff View: Treatment of osteoarthritis using Synvisc in New Zealand white rabbit

Treatment of osteoarthritis using Synvisc in New Zealand white rabbit

INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide. Synvisc® is wildly used as a treatment for OA. This study will investigate the histological changes of OA in rabbits treated with Synvisc®. MATERIALS & METHODS: Twelve NZWR underwent surgery to in...

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Main Authors:	Abdul Hamid, Zahana, Zulkifly, Ahmad Hafiz, Mohamad Amri, Nur Fathonah, Abd. Rahim, Nour El Huda, Hassan, Habibah, Ibrahim, Mohd Zulfadzli, Mohd Jan, Nurul Hafiza, Abu Hassan, Salmah Anim, Mohd Zohari, Sarah Haryati, Zainal Abdullah, Muhamad Ezham, Abdul Jalil, Rosnani, Che Seman, Che Nor Zarida
Format:	Article
Language:	English
Published:	Malaysian Orthopaedic Association 2023
Subjects:	R Medicine (General) RD Surgery RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/109582/7/109582_Treatment%20of%20osteoarthritis%20using%20Synvisc%20in%20New%20Zealand%20white%20rabbit.pdf http://irep.iium.edu.my/109582/ https://www.morthoj.org/supplements/moa-2023/Poster/Ortho-Research/ER12.pdf
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spelling	my.iium.irep.1095822024-01-08T01:56:33Z http://irep.iium.edu.my/109582/ Treatment of osteoarthritis using Synvisc in New Zealand white rabbit Abdul Hamid, Zahana Zulkifly, Ahmad Hafiz Mohamad Amri, Nur Fathonah Abd. Rahim, Nour El Huda Hassan, Habibah Ibrahim, Mohd Zulfadzli Mohd Jan, Nurul Hafiza Abu Hassan, Salmah Anim Mohd Zohari, Sarah Haryati Zainal Abdullah, Muhamad Ezham Abdul Jalil, Rosnani Che Seman, Che Nor Zarida R Medicine (General) RD Surgery RD701 Orthopedics INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide. Synvisc® is wildly used as a treatment for OA. This study will investigate the histological changes of OA in rabbits treated with Synvisc®. MATERIALS & METHODS: Twelve NZWR underwent surgery to induce OA. The rabbits were injected with intraarticular Synvisc® after 3 weeks. It is then euthanized at 3, 6, 12 and 24 weeks according to its group. The knee joint samples were collected and underwent hard tissue processing. The specimens were stained with Masson-Goldner staining. RESULTS: No intraoperative complications were observed. The Synvisc®-treated OA knees at 6 weeks (Figure 1) and at 12 (Figure 2) exhibited no inflammation. Improvement of cartilage thickness was noted. The cartilage is thicker in 12 weeks group compared to 6 weeks group. DISCUSSION: Rabbits treated with Synvisc® had less cartilage degeneration. This cartilage improvement was observed at 6 and 12 weeks after treatment. Specifically, the rabbits treated with Synvisc® improved the cartilage thickness. CONCLUSION: Synvisc® treatment showed histological improvements of OA in rabbits. Malaysian Orthopaedic Association 2023-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/109582/7/109582_Treatment%20of%20osteoarthritis%20using%20Synvisc%20in%20New%20Zealand%20white%20rabbit.pdf Abdul Hamid, Zahana and Zulkifly, Ahmad Hafiz and Mohamad Amri, Nur Fathonah and Abd. Rahim, Nour El Huda and Hassan, Habibah and Ibrahim, Mohd Zulfadzli and Mohd Jan, Nurul Hafiza and Abu Hassan, Salmah Anim and Mohd Zohari, Sarah Haryati and Zainal Abdullah, Muhamad Ezham and Abdul Jalil, Rosnani and Che Seman, Che Nor Zarida (2023) Treatment of osteoarthritis using Synvisc in New Zealand white rabbit. Malaysian Orthopaedic Journal, 16 (Supplement A). ISSN 1985-2533 E-ISSN 2232-111X https://www.morthoj.org/supplements/moa-2023/Poster/Ortho-Research/ER12.pdf
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	R Medicine (General) RD Surgery RD701 Orthopedics
spellingShingle	R Medicine (General) RD Surgery RD701 Orthopedics Abdul Hamid, Zahana Zulkifly, Ahmad Hafiz Mohamad Amri, Nur Fathonah Abd. Rahim, Nour El Huda Hassan, Habibah Ibrahim, Mohd Zulfadzli Mohd Jan, Nurul Hafiza Abu Hassan, Salmah Anim Mohd Zohari, Sarah Haryati Zainal Abdullah, Muhamad Ezham Abdul Jalil, Rosnani Che Seman, Che Nor Zarida Treatment of osteoarthritis using Synvisc in New Zealand white rabbit
description	INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide. Synvisc® is wildly used as a treatment for OA. This study will investigate the histological changes of OA in rabbits treated with Synvisc®. MATERIALS & METHODS: Twelve NZWR underwent surgery to induce OA. The rabbits were injected with intraarticular Synvisc® after 3 weeks. It is then euthanized at 3, 6, 12 and 24 weeks according to its group. The knee joint samples were collected and underwent hard tissue processing. The specimens were stained with Masson-Goldner staining. RESULTS: No intraoperative complications were observed. The Synvisc®-treated OA knees at 6 weeks (Figure 1) and at 12 (Figure 2) exhibited no inflammation. Improvement of cartilage thickness was noted. The cartilage is thicker in 12 weeks group compared to 6 weeks group. DISCUSSION: Rabbits treated with Synvisc® had less cartilage degeneration. This cartilage improvement was observed at 6 and 12 weeks after treatment. Specifically, the rabbits treated with Synvisc® improved the cartilage thickness. CONCLUSION: Synvisc® treatment showed histological improvements of OA in rabbits.
format	Article
author	Abdul Hamid, Zahana Zulkifly, Ahmad Hafiz Mohamad Amri, Nur Fathonah Abd. Rahim, Nour El Huda Hassan, Habibah Ibrahim, Mohd Zulfadzli Mohd Jan, Nurul Hafiza Abu Hassan, Salmah Anim Mohd Zohari, Sarah Haryati Zainal Abdullah, Muhamad Ezham Abdul Jalil, Rosnani Che Seman, Che Nor Zarida
author_facet	Abdul Hamid, Zahana Zulkifly, Ahmad Hafiz Mohamad Amri, Nur Fathonah Abd. Rahim, Nour El Huda Hassan, Habibah Ibrahim, Mohd Zulfadzli Mohd Jan, Nurul Hafiza Abu Hassan, Salmah Anim Mohd Zohari, Sarah Haryati Zainal Abdullah, Muhamad Ezham Abdul Jalil, Rosnani Che Seman, Che Nor Zarida
author_sort	Abdul Hamid, Zahana
title	Treatment of osteoarthritis using Synvisc in New Zealand white rabbit
title_short	Treatment of osteoarthritis using Synvisc in New Zealand white rabbit
title_full	Treatment of osteoarthritis using Synvisc in New Zealand white rabbit
title_fullStr	Treatment of osteoarthritis using Synvisc in New Zealand white rabbit
title_full_unstemmed	Treatment of osteoarthritis using Synvisc in New Zealand white rabbit
title_sort	treatment of osteoarthritis using synvisc in new zealand white rabbit
publisher	Malaysian Orthopaedic Association
publishDate	2023
url	http://irep.iium.edu.my/109582/7/109582_Treatment%20of%20osteoarthritis%20using%20Synvisc%20in%20New%20Zealand%20white%20rabbit.pdf http://irep.iium.edu.my/109582/ https://www.morthoj.org/supplements/moa-2023/Poster/Ortho-Research/ER12.pdf
_version_	1787520333946814464
score	13.211869

Treatment of osteoarthritis using Synvisc in New Zealand white rabbit

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