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Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms

Purpose: To evaluate the short-term effects of artificial tears (ATs) with different viscosity and pH; Systane® Hydration preservative (SH) and non-preservative (SHUD), Optive® preservative (O) and non-preservative (OUD) on patients’ signs and symptoms in normal and dry eye (DE) groups. Methods: 1...

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Main Authors: Che Arif, Fatin Amalina, Hilmi, Mohd Radzi, Mohd. Kamal, Khairidzan, Wolffsohn, James S
Format: Article
Language:English
Published: IIUM Press 2023
Subjects:
RE Ophthalmology
Online Access:http://irep.iium.edu.my/109001/13/109001_Immediate%20effects%20of%20artificial%20tears%20viscosity.pdf
http://irep.iium.edu.my/109001/
https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/862
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spelling my.iium.irep.1090012024-02-27T05:17:10Z http://irep.iium.edu.my/109001/ Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms Che Arif, Fatin Amalina Hilmi, Mohd Radzi Mohd. Kamal, Khairidzan Wolffsohn, James S RE Ophthalmology Purpose: To evaluate the short-term effects of artificial tears (ATs) with different viscosity and pH; Systane® Hydration preservative (SH) and non-preservative (SHUD), Optive® preservative (O) and non-preservative (OUD) on patients’ signs and symptoms in normal and dry eye (DE) groups. Methods: 120 participants (55: DE group, 65: normal group) involved in this prospective, double-masked randomized study. Rheometer and digital pH-meter were used to evaluate the viscosity and pH of all ATs. Ocular discomfort between pre and post- instillation (after 60 minutes interval) was evaluated using Ora CalibraTM Ocular Discomfort and 4-Symptom Questionnaire (OOD4SQ). Drop comfort immediately assessed after ATs instillation using Ora CalibraTM Drop Comfort Scale (ODCS). Tear break-up time (TBUT) and tear meniscus height (TMH) were measured at baseline, 5, 15 and 60 minutes after instillations. Tear ferning pattern (TFP) were observed and compared at baseline and 60 minutes after instillation. Results: Viscosity of all ATs were; SHUD: 32.73cP, SH: 26.7cP, OUD: 14.42cP and O: 13.88cP with pH of 7.74 (SHUD), 7.85 (SH), 7.19 (OUD) and 7.24 (O). Highest DCS was found in SH for both DE (2.00±1.042) and normal group (1.84±0.963). Significant reduction (p<0.05) in all parameters of ocular symptoms (OOD4SQ) were found after instillation of OUD in both groups. TBUT and TMH for both groups increased significantly (p<0.05) from baseline at all time-interval (except TBUT for O in normal group at 5 minutes post-instillation). TFP improved significantly after 60 minutes instillation of all ATs in both groups. Conclusion: All ATs improved TBUT, TMH and TFP in both groups, regardless their viscosity and pH. OUD showed better ocular symptoms improvement and less subjective sensation compared to other tested ATs. IIUM Press 2023-12-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/109001/13/109001_Immediate%20effects%20of%20artificial%20tears%20viscosity.pdf Che Arif, Fatin Amalina and Hilmi, Mohd Radzi and Mohd. Kamal, Khairidzan and Wolffsohn, James S (2023) Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms. International Journal of Allied Health Sciences, 7 (5). pp. 317-335. E-ISSN 2600-8491 https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/862
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RE Ophthalmology
spellingShingle RE Ophthalmology
Che Arif, Fatin Amalina
Hilmi, Mohd Radzi
Mohd. Kamal, Khairidzan
Wolffsohn, James S
Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms
description Purpose: To evaluate the short-term effects of artificial tears (ATs) with different viscosity and pH; Systane® Hydration preservative (SH) and non-preservative (SHUD), Optive® preservative (O) and non-preservative (OUD) on patients’ signs and symptoms in normal and dry eye (DE) groups. Methods: 120 participants (55: DE group, 65: normal group) involved in this prospective, double-masked randomized study. Rheometer and digital pH-meter were used to evaluate the viscosity and pH of all ATs. Ocular discomfort between pre and post- instillation (after 60 minutes interval) was evaluated using Ora CalibraTM Ocular Discomfort and 4-Symptom Questionnaire (OOD4SQ). Drop comfort immediately assessed after ATs instillation using Ora CalibraTM Drop Comfort Scale (ODCS). Tear break-up time (TBUT) and tear meniscus height (TMH) were measured at baseline, 5, 15 and 60 minutes after instillations. Tear ferning pattern (TFP) were observed and compared at baseline and 60 minutes after instillation. Results: Viscosity of all ATs were; SHUD: 32.73cP, SH: 26.7cP, OUD: 14.42cP and O: 13.88cP with pH of 7.74 (SHUD), 7.85 (SH), 7.19 (OUD) and 7.24 (O). Highest DCS was found in SH for both DE (2.00±1.042) and normal group (1.84±0.963). Significant reduction (p<0.05) in all parameters of ocular symptoms (OOD4SQ) were found after instillation of OUD in both groups. TBUT and TMH for both groups increased significantly (p<0.05) from baseline at all time-interval (except TBUT for O in normal group at 5 minutes post-instillation). TFP improved significantly after 60 minutes instillation of all ATs in both groups. Conclusion: All ATs improved TBUT, TMH and TFP in both groups, regardless their viscosity and pH. OUD showed better ocular symptoms improvement and less subjective sensation compared to other tested ATs.
format Article
author Che Arif, Fatin Amalina
Hilmi, Mohd Radzi
Mohd. Kamal, Khairidzan
Wolffsohn, James S
author_facet Che Arif, Fatin Amalina
Hilmi, Mohd Radzi
Mohd. Kamal, Khairidzan
Wolffsohn, James S
author_sort Che Arif, Fatin Amalina
title Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms
title_short Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms
title_full Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms
title_fullStr Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms
title_full_unstemmed Immediate effects of artificial tears viscosity and pH on ocular signs and symptoms
title_sort immediate effects of artificial tears viscosity and ph on ocular signs and symptoms
publisher IIUM Press
publishDate 2023
url http://irep.iium.edu.my/109001/13/109001_Immediate%20effects%20of%20artificial%20tears%20viscosity.pdf
http://irep.iium.edu.my/109001/
https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/862
_version_ 1792146422513008640
score 13.211869

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