Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease
Background: With changes in the epidemiology and treatment of chronic liver disease (CLD), the impact of various etiologies of liver disease on steatosis and advanced fibrosis are uncertain. Methods: A retrospective study was conducted among liver disease patients of various etiologies undergoing...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
John Wiley & Sons Australia
2023
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/108718/1/108718_Frequency%20of%20significant%20steatosis.pdf http://irep.iium.edu.my/108718/2/108718_Frequency%20of%20significant%20steatosis_SCOPUS.pdf http://irep.iium.edu.my/108718/ https://onlinelibrary.wiley.com/doi/10.1111/jgh.16313 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
my.iium.irep.108718 |
|---|---|
| record_format |
dspace |
| spelling |
my.iium.irep.1087182023-12-19T00:31:52Z http://irep.iium.edu.my/108718/ Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease Shahrani, Shahreedhan Singh Gill, Sandeep Sooi, Choong Yeong Skantha, Ruben Chandra Kumar, C. Vikneshwaran Limun, Mohd Fairul Nik Muhamad Affendi, Nik Arsyad Chuah, Kee Huat Khoo, Stanley Rajaram, Ruveena Bhavani Chan, Wah Keong Mahadeva, Sanjiv R Medicine (General) Background: With changes in the epidemiology and treatment of chronic liver disease (CLD), the impact of various etiologies of liver disease on steatosis and advanced fibrosis are uncertain. Methods: A retrospective study was conducted among liver disease patients of various etiologies undergoing transient elastography (TE) over a 9-year duration. Results: Data for 2886 patients were analyzed and had the following demographics: The median age was 60 (IQR: 45-69) years, 51% were males, and ethnicity was predominantly Chinese (52.5%), followed by Malays (34%) and Indians (12.3%). The median CAP score was 272 (IQR: 219-319) dB/m and the median liver stiffness measurement (LSM) score was 6.5 (IQR: 4.9-9.7) kPa. Hepatic steatosis occurred across the spectrum of etiologies of CLD. Among patients with steatosis, the most common etiologies were nonalcoholic fatty liver disease (NAFLD) at 62% and chronic hepatitis B (CHB) at 26.3%. TE findings suggestive of cACLD (10.1-15 kPa) and highly suggestive of cACLD (>15 kPa) were observed in 11.3% and 12.4% of patients, respectively. NAFLD was found to be the most common etiology for cases with suggestive of cACLD (47.2%) and highly suggestive of cACLD (41.5%). Conclusion: Hepatic steatosis is common in CLD, regardless of etiology. Compared with other etiologies, NAFLD is now the leading cause of cACLD. John Wiley & Sons Australia 2023-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/108718/1/108718_Frequency%20of%20significant%20steatosis.pdf application/pdf en http://irep.iium.edu.my/108718/2/108718_Frequency%20of%20significant%20steatosis_SCOPUS.pdf Shahrani, Shahreedhan and Singh Gill, Sandeep and Sooi, Choong Yeong and Skantha, Ruben and Chandra Kumar, C. Vikneshwaran and Limun, Mohd Fairul and Nik Muhamad Affendi, Nik Arsyad and Chuah, Kee Huat and Khoo, Stanley and Rajaram, Ruveena Bhavani and Chan, Wah Keong and Mahadeva, Sanjiv (2023) Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease. Journal of Gastroenterology and Hepatology, 38 (10). pp. 1818-1822. ISSN 0815-9319 E-ISSN 1440-1746 https://onlinelibrary.wiley.com/doi/10.1111/jgh.16313 10.1111/jgh.16313 |
| institution |
Universiti Islam Antarabangsa Malaysia |
| building |
IIUM Library |
| collection |
Institutional Repository |
| continent |
Asia |
| country |
Malaysia |
| content_provider |
International Islamic University Malaysia |
| content_source |
IIUM Repository (IREP) |
| url_provider |
http://irep.iium.edu.my/ |
| language |
English English |
| topic |
R Medicine (General) |
| spellingShingle |
R Medicine (General) Shahrani, Shahreedhan Singh Gill, Sandeep Sooi, Choong Yeong Skantha, Ruben Chandra Kumar, C. Vikneshwaran Limun, Mohd Fairul Nik Muhamad Affendi, Nik Arsyad Chuah, Kee Huat Khoo, Stanley Rajaram, Ruveena Bhavani Chan, Wah Keong Mahadeva, Sanjiv Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease |
| description |
Background: With changes in the epidemiology and treatment of chronic liver disease (CLD), the impact of various etiologies of liver disease on steatosis and advanced fibrosis are uncertain.
Methods: A retrospective study was conducted among liver disease patients of various etiologies undergoing transient elastography (TE) over a 9-year duration.
Results: Data for 2886 patients were analyzed and had the following demographics: The median age was 60 (IQR: 45-69) years, 51% were males, and ethnicity was predominantly Chinese (52.5%), followed by Malays (34%) and Indians (12.3%). The median CAP score was 272 (IQR: 219-319) dB/m and the median liver stiffness measurement (LSM) score was 6.5 (IQR: 4.9-9.7) kPa. Hepatic steatosis occurred across the spectrum of etiologies of CLD. Among patients with steatosis, the most common etiologies were nonalcoholic fatty liver disease (NAFLD) at 62% and chronic hepatitis B (CHB) at 26.3%. TE findings suggestive of cACLD (10.1-15 kPa) and highly suggestive of cACLD (>15 kPa) were observed in 11.3% and 12.4% of patients, respectively. NAFLD was found to be the most common etiology for cases with suggestive of cACLD (47.2%) and highly suggestive of cACLD (41.5%).
Conclusion: Hepatic steatosis is common in CLD, regardless of etiology. Compared with other etiologies, NAFLD is now the leading cause of cACLD. |
| format |
Article |
| author |
Shahrani, Shahreedhan Singh Gill, Sandeep Sooi, Choong Yeong Skantha, Ruben Chandra Kumar, C. Vikneshwaran Limun, Mohd Fairul Nik Muhamad Affendi, Nik Arsyad Chuah, Kee Huat Khoo, Stanley Rajaram, Ruveena Bhavani Chan, Wah Keong Mahadeva, Sanjiv |
| author_facet |
Shahrani, Shahreedhan Singh Gill, Sandeep Sooi, Choong Yeong Skantha, Ruben Chandra Kumar, C. Vikneshwaran Limun, Mohd Fairul Nik Muhamad Affendi, Nik Arsyad Chuah, Kee Huat Khoo, Stanley Rajaram, Ruveena Bhavani Chan, Wah Keong Mahadeva, Sanjiv |
| author_sort |
Shahrani, Shahreedhan |
| title |
Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease |
| title_short |
Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease |
| title_full |
Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease |
| title_fullStr |
Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease |
| title_full_unstemmed |
Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease |
| title_sort |
frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease |
| publisher |
John Wiley & Sons Australia |
| publishDate |
2023 |
| url |
http://irep.iium.edu.my/108718/1/108718_Frequency%20of%20significant%20steatosis.pdf http://irep.iium.edu.my/108718/2/108718_Frequency%20of%20significant%20steatosis_SCOPUS.pdf http://irep.iium.edu.my/108718/ https://onlinelibrary.wiley.com/doi/10.1111/jgh.16313 |
| _version_ |
1787131897613123584 |
| score |
13.211869 |