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Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel

INTRODUCTION:Collagen is the key component of the extracellular matrix that plays a critical role in the strength and quality of the healed wound. Eurycoma longifoliaJack root extract (TA) has been documented as an anti-inflammatory, antioxidant, and antimicrobial agent that...

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Main Authors: Al-Bayati, Maryam Riyadh Yaseen, Faisal, Ghasak Ghazi, Abd. Fuaat, Azliana, Ahmad Affandi, Khairunisa, Alallam, Batoul
Format: Article
Language:English
English
Published: Kulliyyah of Medicine, International Islamic University Malaysia 2023
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/107625/7/107625_Improved%20quality%20of%20healed%20wounds%20with%20topical%20application.pdf
http://irep.iium.edu.my/107625/8/107625_Improved%20quality%20of%20healed%20wounds%20with%20topical%20application_Scopus.pdf
http://irep.iium.edu.my/107625/
https://journals.iium.edu.my/kom/index.php/imjm/issue/view/53
https://doi.org/10.31436/imjm.v22i4.2325
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spelling my.iium.irep.1076252023-12-26T07:25:02Z http://irep.iium.edu.my/107625/ Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel Al-Bayati, Maryam Riyadh Yaseen Faisal, Ghasak Ghazi Abd. Fuaat, Azliana Ahmad Affandi, Khairunisa Alallam, Batoul RB Pathology INTRODUCTION:Collagen is the key component of the extracellular matrix that plays a critical role in the strength and quality of the healed wound. Eurycoma longifoliaJack root extract (TA) has been documented as an anti-inflammatory, antioxidant, and antimicrobial agent that may improve the quality of healed wounds. The objective of this study is to investigate the effect of topical application of TA hydrogel on the quality of the healed skin in rats. MATERIALS AND METHODS: Twenty male Sprague Dawley rats were grouped into 4 groups: Negative control, Hydrocyn®aqua gel positive control, vehicle (Xanthan) hydrogel, and Eurycoma longifolia Jack (TA) hydrogel. Treatments were applied twice daily starting on wounding day until day 21. An excisional wound was created on the back of 20 rats. Tissue samples of the healed skin were collected for histological examination by measuring the epidermal and dermal thicknesses and evaluating the collagen fibre quality by VVG stain. RESULTS:The TA hydrogel grouphad the thickest newly formed epidermis compared with the other experimental groups. For the dermal thickness, compared with the vehicle (xanthan) hydrogel group, TA hydrogel, and Hydrocyn aqua® gel positive control groups showed significantly increased thickness withpvalues 0.020 and 0.045, respectively. Histologically TA hydrogel group showed a significant increase in mixed-oriented collagen fibres, and fascicular collagen bundles and showed profound collagen density. CONCLUSION: TA hydrogel improved the quality of healed skin by increasing the epidermal/dermal thicknesses and enhancing the quality of newly produced collagen fibres. It can be considered a promising and effective wound-healing agent Kulliyyah of Medicine, International Islamic University Malaysia 2023-10-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/107625/7/107625_Improved%20quality%20of%20healed%20wounds%20with%20topical%20application.pdf application/pdf en http://irep.iium.edu.my/107625/8/107625_Improved%20quality%20of%20healed%20wounds%20with%20topical%20application_Scopus.pdf Al-Bayati, Maryam Riyadh Yaseen and Faisal, Ghasak Ghazi and Abd. Fuaat, Azliana and Ahmad Affandi, Khairunisa and Alallam, Batoul (2023) Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel. IIUM Medical Journal Malaysia, 22 (4). pp. 115-121. ISSN 1823-4631 E-ISSN 2735-2285 https://journals.iium.edu.my/kom/index.php/imjm/issue/view/53 https://doi.org/10.31436/imjm.v22i4.2325
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RB Pathology
spellingShingle RB Pathology
Al-Bayati, Maryam Riyadh Yaseen
Faisal, Ghasak Ghazi
Abd. Fuaat, Azliana
Ahmad Affandi, Khairunisa
Alallam, Batoul
Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel
description INTRODUCTION:Collagen is the key component of the extracellular matrix that plays a critical role in the strength and quality of the healed wound. Eurycoma longifoliaJack root extract (TA) has been documented as an anti-inflammatory, antioxidant, and antimicrobial agent that may improve the quality of healed wounds. The objective of this study is to investigate the effect of topical application of TA hydrogel on the quality of the healed skin in rats. MATERIALS AND METHODS: Twenty male Sprague Dawley rats were grouped into 4 groups: Negative control, Hydrocyn®aqua gel positive control, vehicle (Xanthan) hydrogel, and Eurycoma longifolia Jack (TA) hydrogel. Treatments were applied twice daily starting on wounding day until day 21. An excisional wound was created on the back of 20 rats. Tissue samples of the healed skin were collected for histological examination by measuring the epidermal and dermal thicknesses and evaluating the collagen fibre quality by VVG stain. RESULTS:The TA hydrogel grouphad the thickest newly formed epidermis compared with the other experimental groups. For the dermal thickness, compared with the vehicle (xanthan) hydrogel group, TA hydrogel, and Hydrocyn aqua® gel positive control groups showed significantly increased thickness withpvalues 0.020 and 0.045, respectively. Histologically TA hydrogel group showed a significant increase in mixed-oriented collagen fibres, and fascicular collagen bundles and showed profound collagen density. CONCLUSION: TA hydrogel improved the quality of healed skin by increasing the epidermal/dermal thicknesses and enhancing the quality of newly produced collagen fibres. It can be considered a promising and effective wound-healing agent
format Article
author Al-Bayati, Maryam Riyadh Yaseen
Faisal, Ghasak Ghazi
Abd. Fuaat, Azliana
Ahmad Affandi, Khairunisa
Alallam, Batoul
author_facet Al-Bayati, Maryam Riyadh Yaseen
Faisal, Ghasak Ghazi
Abd. Fuaat, Azliana
Ahmad Affandi, Khairunisa
Alallam, Batoul
author_sort Al-Bayati, Maryam Riyadh Yaseen
title Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel
title_short Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel
title_full Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel
title_fullStr Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel
title_full_unstemmed Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel
title_sort improved quality of healed wounds with topical application of eurycoma longifolia jack root extract hydrogel
publisher Kulliyyah of Medicine, International Islamic University Malaysia
publishDate 2023
url http://irep.iium.edu.my/107625/7/107625_Improved%20quality%20of%20healed%20wounds%20with%20topical%20application.pdf
http://irep.iium.edu.my/107625/8/107625_Improved%20quality%20of%20healed%20wounds%20with%20topical%20application_Scopus.pdf
http://irep.iium.edu.my/107625/
https://journals.iium.edu.my/kom/index.php/imjm/issue/view/53
https://doi.org/10.31436/imjm.v22i4.2325
_version_ 1787131882574446592
score 13.211869

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