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The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study

Introduction Epilepsy has a high incidence among infants during their first year of life, yet the prognosis can vary significantly. While considerable research has been conducted on infantile spasms, studies examining infantile-onset epilepsy, excluding infantile spasms, remain limited, particularl...

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Main Authors:	Anuar, Muhamad Azamin, Zainal Abidin, Muhammad 'Adil, Tan, Soo Hong, Yeap, Cai Fong, Yahaya, Nor Azni
Format:	Article
Language:	English English English
Published:	Elsevier 2024
Subjects:	RJ Pediatrics
Online Access:	http://irep.iium.edu.my/107581/1/107581_The%20clinical%20characteristics_In%20Press.pdf http://irep.iium.edu.my/107581/7/107981_The%20clinical%20characteristics.pdf http://irep.iium.edu.my/107581/8/107581_The%20clinical%20characteristics_Scopus.pdf http://irep.iium.edu.my/107581/ https://www.sciencedirect.com/science/article/abs/pii/S0887899423003545
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spelling	my.iium.irep.1075812024-02-23T01:43:08Z http://irep.iium.edu.my/107581/ The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study Anuar, Muhamad Azamin Zainal Abidin, Muhammad 'Adil Tan, Soo Hong Yeap, Cai Fong Yahaya, Nor Azni RJ Pediatrics Introduction Epilepsy has a high incidence among infants during their first year of life, yet the prognosis can vary significantly. While considerable research has been conducted on infantile spasms, studies examining infantile-onset epilepsy, excluding infantile spasms, remain limited, particularly concerning the factors influencing outcomes. Therefore, our study aims to elucidate seizure control, developmental outcomes, and prognostic factors in infants with epilepsy during their first year of life, within a single-center study in Malaysia. Methods We retrieved data from patients who experienced seizures before the age of 12 months and were followed for over 2 years, using electronic patient records at Hospital Raja Perempuan Zainab II in Kelantan, a state on Malaysia’s east coast. We retrospectively reviewed these records and assessed clinical outcomes based on the last follow-up. Results Out of 75 patients, 61 (81.3%) achieved good seizure control or remission. At the last follow-up, 24 (32%) exhibited developmental delay, while 19 (25.3%) displayed abnormal neuroimaging. Patients with abnormal background EEG activity, as well as abnormal radiological findings, were more likely to experience poor seizure control and unfavorable developmental outcomes (P<0.05). Conclusion Our study underscores that most infants with epilepsy can achieve seizure remission. However, poor seizure control and developmental delay are associated with abnormal EEG background and characteristics, as well as neuroimaging abnormalities. The management of infantile onset epilepsies may necessitate substantial resources and precise interventions to enhance overall outcomes. Elsevier 2024-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/107581/1/107581_The%20clinical%20characteristics_In%20Press.pdf application/pdf en http://irep.iium.edu.my/107581/7/107981_The%20clinical%20characteristics.pdf application/pdf en http://irep.iium.edu.my/107581/8/107581_The%20clinical%20characteristics_Scopus.pdf Anuar, Muhamad Azamin and Zainal Abidin, Muhammad 'Adil and Tan, Soo Hong and Yeap, Cai Fong and Yahaya, Nor Azni (2024) The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study. Pediatric Neurology, 150. pp. 10-14. ISSN 0887-8994 E-ISSN 1873-5150 https://www.sciencedirect.com/science/article/abs/pii/S0887899423003545 10.1016/j.pediatrneurol.2023.10.004
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English English
topic	RJ Pediatrics
spellingShingle	RJ Pediatrics Anuar, Muhamad Azamin Zainal Abidin, Muhammad 'Adil Tan, Soo Hong Yeap, Cai Fong Yahaya, Nor Azni The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study
description	Introduction Epilepsy has a high incidence among infants during their first year of life, yet the prognosis can vary significantly. While considerable research has been conducted on infantile spasms, studies examining infantile-onset epilepsy, excluding infantile spasms, remain limited, particularly concerning the factors influencing outcomes. Therefore, our study aims to elucidate seizure control, developmental outcomes, and prognostic factors in infants with epilepsy during their first year of life, within a single-center study in Malaysia. Methods We retrieved data from patients who experienced seizures before the age of 12 months and were followed for over 2 years, using electronic patient records at Hospital Raja Perempuan Zainab II in Kelantan, a state on Malaysia’s east coast. We retrospectively reviewed these records and assessed clinical outcomes based on the last follow-up. Results Out of 75 patients, 61 (81.3%) achieved good seizure control or remission. At the last follow-up, 24 (32%) exhibited developmental delay, while 19 (25.3%) displayed abnormal neuroimaging. Patients with abnormal background EEG activity, as well as abnormal radiological findings, were more likely to experience poor seizure control and unfavorable developmental outcomes (P<0.05). Conclusion Our study underscores that most infants with epilepsy can achieve seizure remission. However, poor seizure control and developmental delay are associated with abnormal EEG background and characteristics, as well as neuroimaging abnormalities. The management of infantile onset epilepsies may necessitate substantial resources and precise interventions to enhance overall outcomes.
format	Article
author	Anuar, Muhamad Azamin Zainal Abidin, Muhammad 'Adil Tan, Soo Hong Yeap, Cai Fong Yahaya, Nor Azni
author_facet	Anuar, Muhamad Azamin Zainal Abidin, Muhammad 'Adil Tan, Soo Hong Yeap, Cai Fong Yahaya, Nor Azni
author_sort	Anuar, Muhamad Azamin
title	The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study
title_short	The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study
title_full	The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study
title_fullStr	The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study
title_full_unstemmed	The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study
title_sort	clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study
publisher	Elsevier
publishDate	2024
url	http://irep.iium.edu.my/107581/1/107581_The%20clinical%20characteristics_In%20Press.pdf http://irep.iium.edu.my/107581/7/107981_The%20clinical%20characteristics.pdf http://irep.iium.edu.my/107581/8/107581_The%20clinical%20characteristics_Scopus.pdf http://irep.iium.edu.my/107581/ https://www.sciencedirect.com/science/article/abs/pii/S0887899423003545
_version_	1792146410505764864
score	13.211869

The clinical characteristics and outcomes of infantile seizures in the first year of life: a single-center study

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