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Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection

Dyslipidaemia is a biochemical alteration connected to the pathology accompanying COVID-19 infection. Dyslipidaemia has been recognized as a common complication in COVID-19 infection exerting a significant effect on severity and mortality in COVID-19 infected patients. Disturbance of lipid profile i...

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Main Authors: Hamad Zubi, Zainab Bubakr, Hamad Alfarisi, Hamad Abdulsalam
Format: Article
Language:English
Published: Science Publishing Group 2023
Subjects:
RC627 Specialties of Internal Medicine-Metabolic Diseases
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Online Access:http://irep.iium.edu.my/105803/7/105803_Dyslipidaemia%20and%20its%20underlying%20mechanisms%20in%20Coronavirus.pdf
http://irep.iium.edu.my/105803/
https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=355&doi=10.11648/j.ijcts.20230903.12
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spelling my.iium.irep.1058032023-11-15T03:36:04Z http://irep.iium.edu.my/105803/ Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection Hamad Zubi, Zainab Bubakr Hamad Alfarisi, Hamad Abdulsalam RC627 Specialties of Internal Medicine-Metabolic Diseases RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Dyslipidaemia is a biochemical alteration connected to the pathology accompanying COVID-19 infection. Dyslipidaemia has been recognized as a common complication in COVID-19 infection exerting a significant effect on severity and mortality in COVID-19 infected patients. Disturbance of lipid profile in COVID-19 infection is diverse and shown to have various presentations. Inflammatory markers and acute phase reactants found to have a relation with the disrupted lipid profile during COVID-19 infection. The objective of this short review is to outline the altered lipid profile in COVID-19 infected patient, and to highlight the relationship between dyslipidaemia, inflammatory markers, severity and morbidity of COVID infection. The implemented methodology in this comprehensive short review is based on analysis of the recent published literature pertaining dyslipidaemia in COVID-19 infection. The core literature for this review is the published clinical studies and the case reports that studied the effects of COVID-19 infection on lipid profile. This review showed that low total cholesterol and high-density lipoprotein cholesterol (HDL-C) in addition to elevated low-density lipoprotein cholesterol (LDL-C) constitute the commonest altered lipid profile in COVID-19 infected patients. Lipid peroxidation, oxidative stress and inflammation are the postulated pathogenic mechanisms for dyslipidaemia during COVID-19 infection. However, the results about status of triglycerides (TG) in COVID-19 infection was non-conclusive. Further studies may be required to suite the lipidomic status of triglycerides in COVID-19 infected patients. Science Publishing Group 2023-06-21 Article PeerReviewed application/pdf en http://irep.iium.edu.my/105803/7/105803_Dyslipidaemia%20and%20its%20underlying%20mechanisms%20in%20Coronavirus.pdf Hamad Zubi, Zainab Bubakr and Hamad Alfarisi, Hamad Abdulsalam (2023) Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection. International Journal of Cardiovascular and Thoracic Surgery, 9 (3). pp. 27-31. ISSN 2575-4866 E-ISSN 2575-4882 https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=355&doi=10.11648/j.ijcts.20230903.12 10.11648/j.ijcts.20230903.12
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC627 Specialties of Internal Medicine-Metabolic Diseases
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
spellingShingle RC627 Specialties of Internal Medicine-Metabolic Diseases
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Hamad Zubi, Zainab Bubakr
Hamad Alfarisi, Hamad Abdulsalam
Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection
description Dyslipidaemia is a biochemical alteration connected to the pathology accompanying COVID-19 infection. Dyslipidaemia has been recognized as a common complication in COVID-19 infection exerting a significant effect on severity and mortality in COVID-19 infected patients. Disturbance of lipid profile in COVID-19 infection is diverse and shown to have various presentations. Inflammatory markers and acute phase reactants found to have a relation with the disrupted lipid profile during COVID-19 infection. The objective of this short review is to outline the altered lipid profile in COVID-19 infected patient, and to highlight the relationship between dyslipidaemia, inflammatory markers, severity and morbidity of COVID infection. The implemented methodology in this comprehensive short review is based on analysis of the recent published literature pertaining dyslipidaemia in COVID-19 infection. The core literature for this review is the published clinical studies and the case reports that studied the effects of COVID-19 infection on lipid profile. This review showed that low total cholesterol and high-density lipoprotein cholesterol (HDL-C) in addition to elevated low-density lipoprotein cholesterol (LDL-C) constitute the commonest altered lipid profile in COVID-19 infected patients. Lipid peroxidation, oxidative stress and inflammation are the postulated pathogenic mechanisms for dyslipidaemia during COVID-19 infection. However, the results about status of triglycerides (TG) in COVID-19 infection was non-conclusive. Further studies may be required to suite the lipidomic status of triglycerides in COVID-19 infected patients.
format Article
author Hamad Zubi, Zainab Bubakr
Hamad Alfarisi, Hamad Abdulsalam
author_facet Hamad Zubi, Zainab Bubakr
Hamad Alfarisi, Hamad Abdulsalam
author_sort Hamad Zubi, Zainab Bubakr
title Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection
title_short Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection
title_full Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection
title_fullStr Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection
title_full_unstemmed Dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (COVID-19) infection
title_sort dyslipidaemia and its underlying mechanisms in coronavirus disease 2019 (covid-19) infection
publisher Science Publishing Group
publishDate 2023
url http://irep.iium.edu.my/105803/7/105803_Dyslipidaemia%20and%20its%20underlying%20mechanisms%20in%20Coronavirus.pdf
http://irep.iium.edu.my/105803/
https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=355&doi=10.11648/j.ijcts.20230903.12
_version_ 1783876084296581120
score 13.211869

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