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Reactive oxygen species and antioxidant system in selected skin disorders

The skin has a solid protective system that includes the stratum corneum as the primary barrier and a complete antioxidant defence system to maintain the skin’s normal redox homeostasis. The epidermal and dermal cells are continuously exposed to physiological levels of reactive oxygen species...

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Main Author: Md. Jaffri, Juliana
Format: Article
Language:English
English
Published: Penerbit Universiti Sains Malaysia 2023
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/104338/2/104338_Reactive%20oxygen%20species%20and%20antioxidant%20system.pdf
http://irep.iium.edu.my/104338/3/104338_Reactive%20oxygen%20species%20and%20antioxidant%20system_SCOPUS.pdf
http://irep.iium.edu.my/104338/
http://www.mjms.usm.my/current.html
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spelling my.iium.irep.1043382023-12-06T02:55:47Z http://irep.iium.edu.my/104338/ Reactive oxygen species and antioxidant system in selected skin disorders Md. Jaffri, Juliana RS Pharmacy and materia medica The skin has a solid protective system that includes the stratum corneum as the primary barrier and a complete antioxidant defence system to maintain the skin’s normal redox homeostasis. The epidermal and dermal cells are continuously exposed to physiological levels of reactive oxygen species (ROS) originating from cellular metabolic activities. Environmental insults, such as ultraviolet (UV) rays and air pollutants, also generate ROS that can contribute to structural damage of the skin. The antioxidant defence system ensures that the ROS level remains within the safe limit. In certain skin disorders, oxidative stress plays an important role, and there is an established interplay between oxidative stress and inflammation in the development of the condition. Lower levels of skin antioxidants indicate that oxidative stress may mediate the pathogenesis of the disorder. Accordingly, the total antioxidant level was also found to be lower in individuals with skin disorders in individuals with normal skin conditions. This review attempts to summarise the skin oxidant sources and antioxidant system. In addition, both skin and total antioxidant status of individuals with psoriasis, acne vulgaris, vitiligo and atopic dermatitis (AD), as well as their associations with the progression of these disorders will be reviewed. Penerbit Universiti Sains Malaysia 2023-02-28 Article PeerReviewed application/pdf en http://irep.iium.edu.my/104338/2/104338_Reactive%20oxygen%20species%20and%20antioxidant%20system.pdf application/pdf en http://irep.iium.edu.my/104338/3/104338_Reactive%20oxygen%20species%20and%20antioxidant%20system_SCOPUS.pdf Md. Jaffri, Juliana (2023) Reactive oxygen species and antioxidant system in selected skin disorders. Malaysian Journal of Medical Sciences, 30 (1). pp. 7-20. ISSN 1394-195X E-ISSN 2180-4303 http://www.mjms.usm.my/current.html 10.21315/mjms2023.30.1.2
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Md. Jaffri, Juliana
Reactive oxygen species and antioxidant system in selected skin disorders
description The skin has a solid protective system that includes the stratum corneum as the primary barrier and a complete antioxidant defence system to maintain the skin’s normal redox homeostasis. The epidermal and dermal cells are continuously exposed to physiological levels of reactive oxygen species (ROS) originating from cellular metabolic activities. Environmental insults, such as ultraviolet (UV) rays and air pollutants, also generate ROS that can contribute to structural damage of the skin. The antioxidant defence system ensures that the ROS level remains within the safe limit. In certain skin disorders, oxidative stress plays an important role, and there is an established interplay between oxidative stress and inflammation in the development of the condition. Lower levels of skin antioxidants indicate that oxidative stress may mediate the pathogenesis of the disorder. Accordingly, the total antioxidant level was also found to be lower in individuals with skin disorders in individuals with normal skin conditions. This review attempts to summarise the skin oxidant sources and antioxidant system. In addition, both skin and total antioxidant status of individuals with psoriasis, acne vulgaris, vitiligo and atopic dermatitis (AD), as well as their associations with the progression of these disorders will be reviewed.
format Article
author Md. Jaffri, Juliana
author_facet Md. Jaffri, Juliana
author_sort Md. Jaffri, Juliana
title Reactive oxygen species and antioxidant system in selected skin disorders
title_short Reactive oxygen species and antioxidant system in selected skin disorders
title_full Reactive oxygen species and antioxidant system in selected skin disorders
title_fullStr Reactive oxygen species and antioxidant system in selected skin disorders
title_full_unstemmed Reactive oxygen species and antioxidant system in selected skin disorders
title_sort reactive oxygen species and antioxidant system in selected skin disorders
publisher Penerbit Universiti Sains Malaysia
publishDate 2023
url http://irep.iium.edu.my/104338/2/104338_Reactive%20oxygen%20species%20and%20antioxidant%20system.pdf
http://irep.iium.edu.my/104338/3/104338_Reactive%20oxygen%20species%20and%20antioxidant%20system_SCOPUS.pdf
http://irep.iium.edu.my/104338/
http://www.mjms.usm.my/current.html
_version_ 1784511207464501248
score 13.211869

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