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Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review

Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy (NVP), which can lead to extreme dehydration, significant weight loss, and electrolyte and metabolic imbalances. Importantly, early identification of HG symptoms can help to reduce its severity and prevent complicat...

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Main Authors: Mohd Nisfu, Farah Ratulfazira, Roslan, Madihah, Mohd Arifin, Siti Roshaidai, Zainuddin, Norafiza
Format: Article
Language:English
English
Published: University Malaya 2023
Subjects:
QH426 Genetics
RG Gynecology and obstetrics
RG551 Pregnancy
Online Access:http://irep.iium.edu.my/104073/1/104073_Genetic%20and%20maternal%20factors.pdf
http://irep.iium.edu.my/104073/2/104073_Genetic%20and%20maternal%20factors_SCOPUS.pdf
http://irep.iium.edu.my/104073/
https://jummec.um.edu.my/index.php/jummec/about
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spelling my.iium.irep.1040732024-06-20T04:00:00Z http://irep.iium.edu.my/104073/ Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review Mohd Nisfu, Farah Ratulfazira Roslan, Madihah Mohd Arifin, Siti Roshaidai Zainuddin, Norafiza QH426 Genetics RG Gynecology and obstetrics RG551 Pregnancy Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy (NVP), which can lead to extreme dehydration, significant weight loss, and electrolyte and metabolic imbalances. Importantly, early identification of HG symptoms can help to reduce its severity and prevent complications. Although HG is associated with many adverse maternal and fetal outcomes, there is limited understanding of the risk factors. This review provides current data on genetic and maternal factors that are linked to HG. All observational studies published in English that investigated the genetic or maternal factors associated with HG from 2011 until 2021 were systematically searched using the PubMed, Scopus, and ProQuest electronic databases. A total of 1462 citation titles was identified, of which 47 potentially relevant abstracts were screened. Of those, 15 studies met the inclusion and exclusion criteria. The genetic variants in the ryanodine receptor 2 gene (RYR2), growth differentiation factor-15 (GDF15), and protein-coding insulin-like growth factor-binding protein 7 (IGFBP7) were found to be associated with HG. On the other hand, several potential maternal factors contributing to the onset of HG were age, Helicobacter pylori infection, body mass index (BMI) status, a history of HG in a previous pregnancy, carrying a female fetus, high serotonin levels, and reproductive factors. In view of the lack of strength of the overall evidence for risk factors related to HG, it is first imperative to establish a precise definition for HG in a diverse study population. Nevertheless, to conclude, this review was able to provide current data on genetic and maternal factors that are associated with HG. University Malaya 2023-03-13 Article PeerReviewed application/pdf en http://irep.iium.edu.my/104073/1/104073_Genetic%20and%20maternal%20factors.pdf application/pdf en http://irep.iium.edu.my/104073/2/104073_Genetic%20and%20maternal%20factors_SCOPUS.pdf Mohd Nisfu, Farah Ratulfazira and Roslan, Madihah and Mohd Arifin, Siti Roshaidai and Zainuddin, Norafiza (2023) Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review. Journal of Health and Translational Medicine, 26 (1). pp. 38-48. ISSN 1823-7339 E-ISSN 2289-392X https://jummec.um.edu.my/index.php/jummec/about
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QH426 Genetics
RG Gynecology and obstetrics
RG551 Pregnancy
spellingShingle QH426 Genetics
RG Gynecology and obstetrics
RG551 Pregnancy
Mohd Nisfu, Farah Ratulfazira
Roslan, Madihah
Mohd Arifin, Siti Roshaidai
Zainuddin, Norafiza
Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review
description Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy (NVP), which can lead to extreme dehydration, significant weight loss, and electrolyte and metabolic imbalances. Importantly, early identification of HG symptoms can help to reduce its severity and prevent complications. Although HG is associated with many adverse maternal and fetal outcomes, there is limited understanding of the risk factors. This review provides current data on genetic and maternal factors that are linked to HG. All observational studies published in English that investigated the genetic or maternal factors associated with HG from 2011 until 2021 were systematically searched using the PubMed, Scopus, and ProQuest electronic databases. A total of 1462 citation titles was identified, of which 47 potentially relevant abstracts were screened. Of those, 15 studies met the inclusion and exclusion criteria. The genetic variants in the ryanodine receptor 2 gene (RYR2), growth differentiation factor-15 (GDF15), and protein-coding insulin-like growth factor-binding protein 7 (IGFBP7) were found to be associated with HG. On the other hand, several potential maternal factors contributing to the onset of HG were age, Helicobacter pylori infection, body mass index (BMI) status, a history of HG in a previous pregnancy, carrying a female fetus, high serotonin levels, and reproductive factors. In view of the lack of strength of the overall evidence for risk factors related to HG, it is first imperative to establish a precise definition for HG in a diverse study population. Nevertheless, to conclude, this review was able to provide current data on genetic and maternal factors that are associated with HG.
format Article
author Mohd Nisfu, Farah Ratulfazira
Roslan, Madihah
Mohd Arifin, Siti Roshaidai
Zainuddin, Norafiza
author_facet Mohd Nisfu, Farah Ratulfazira
Roslan, Madihah
Mohd Arifin, Siti Roshaidai
Zainuddin, Norafiza
author_sort Mohd Nisfu, Farah Ratulfazira
title Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review
title_short Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review
title_full Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review
title_fullStr Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review
title_full_unstemmed Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review
title_sort genetic and maternal factors in hyperemesis gravidarum: a systematic review
publisher University Malaya
publishDate 2023
url http://irep.iium.edu.my/104073/1/104073_Genetic%20and%20maternal%20factors.pdf
http://irep.iium.edu.my/104073/2/104073_Genetic%20and%20maternal%20factors_SCOPUS.pdf
http://irep.iium.edu.my/104073/
https://jummec.um.edu.my/index.php/jummec/about
_version_ 1802976963293347840
score 13.211869

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