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Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin

Gelatin is used as an additive in medicine, food, and cosmetics. Gelatin from goatskin is a new excipient that has not been explored by researchers, including for hard-shell capsules. The aim of this study was to evaluate and characterize the hard-shell capsules produced from goatskin gelatin. The g...

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Main Authors: Zilhadia, Zilhadia, Harahap, Yahdiana, Jaswir, Irwandi, Anwar, Effionora
Format: Article
Language:English
English
Published: Multidisciplinary Digital Publishing Institute (MDPI) 2022
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/103818/1/103818_Evaluation%20and%20characterization%20of%20hard-shell%20capsules.pdf
http://irep.iium.edu.my/103818/2/103818_Evaluation%20and%20characterization%20of%20hard-shell%20capsules_SCOPUS.pdf
http://irep.iium.edu.my/103818/
https://www.mdpi.com/2073-4360/14/20/4416
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spelling my.iium.irep.1038182023-03-02T03:50:09Z http://irep.iium.edu.my/103818/ Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin Zilhadia, Zilhadia Harahap, Yahdiana Jaswir, Irwandi Anwar, Effionora QD Chemistry Gelatin is used as an additive in medicine, food, and cosmetics. Gelatin from goatskin is a new excipient that has not been explored by researchers, including for hard-shell capsules. The aim of this study was to evaluate and characterize the hard-shell capsules produced from goatskin gelatin. The goatskin gelatin was extracted by an acid hydrolysis method, and the functional properties were investigated. Hard-shell capsules were then produced from goatskin gelatin, evaluated, and characterized. The gelatin extracted from goatskin had 56.9% ± 0.95 clarity and a pH of 5.11 ± 0.09, 97.51% ± 1.1 protein content, 9.23% ± 0.08 water content, 0.18% ± 0.07 ash content, 2.08% ± 0.35 fat content, gel strength of 298 ± 2.64 gbloom, and viscosity of 27.33 ± 2.07 mPs. The gelatin has met the requirements to be made into hard-shell capsules. The average weight of the hard-shell capsules produced was 96.9 mg with 8.69 standard deviation. The average size of the body and cap length was 18.84 ± 0.64 mm and 10.98 ± 0.30 mm, respectively. The results of capsule evaluation and characterization were as follows: the pH was 4.82 ± 1,27, water content was 10.03 ± 0.21, disintegration time was 4.02 ± 2.09 min, and there was no microbial growth. Thus, the capsules made have met the requirements and can be produced in a large quantity. Multidisciplinary Digital Publishing Institute (MDPI) 2022-10-19 Article PeerReviewed application/pdf en http://irep.iium.edu.my/103818/1/103818_Evaluation%20and%20characterization%20of%20hard-shell%20capsules.pdf application/pdf en http://irep.iium.edu.my/103818/2/103818_Evaluation%20and%20characterization%20of%20hard-shell%20capsules_SCOPUS.pdf Zilhadia, Zilhadia and Harahap, Yahdiana and Jaswir, Irwandi and Anwar, Effionora (2022) Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin. Polymers, 14 (20). pp. 1-13. E-ISSN 2073-4360 https://www.mdpi.com/2073-4360/14/20/4416 10.3390/polym14204416
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QD Chemistry
spellingShingle QD Chemistry
Zilhadia, Zilhadia
Harahap, Yahdiana
Jaswir, Irwandi
Anwar, Effionora
Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin
description Gelatin is used as an additive in medicine, food, and cosmetics. Gelatin from goatskin is a new excipient that has not been explored by researchers, including for hard-shell capsules. The aim of this study was to evaluate and characterize the hard-shell capsules produced from goatskin gelatin. The goatskin gelatin was extracted by an acid hydrolysis method, and the functional properties were investigated. Hard-shell capsules were then produced from goatskin gelatin, evaluated, and characterized. The gelatin extracted from goatskin had 56.9% ± 0.95 clarity and a pH of 5.11 ± 0.09, 97.51% ± 1.1 protein content, 9.23% ± 0.08 water content, 0.18% ± 0.07 ash content, 2.08% ± 0.35 fat content, gel strength of 298 ± 2.64 gbloom, and viscosity of 27.33 ± 2.07 mPs. The gelatin has met the requirements to be made into hard-shell capsules. The average weight of the hard-shell capsules produced was 96.9 mg with 8.69 standard deviation. The average size of the body and cap length was 18.84 ± 0.64 mm and 10.98 ± 0.30 mm, respectively. The results of capsule evaluation and characterization were as follows: the pH was 4.82 ± 1,27, water content was 10.03 ± 0.21, disintegration time was 4.02 ± 2.09 min, and there was no microbial growth. Thus, the capsules made have met the requirements and can be produced in a large quantity.
format Article
author Zilhadia, Zilhadia
Harahap, Yahdiana
Jaswir, Irwandi
Anwar, Effionora
author_facet Zilhadia, Zilhadia
Harahap, Yahdiana
Jaswir, Irwandi
Anwar, Effionora
author_sort Zilhadia, Zilhadia
title Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin
title_short Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin
title_full Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin
title_fullStr Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin
title_full_unstemmed Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin
title_sort evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin
publisher Multidisciplinary Digital Publishing Institute (MDPI)
publishDate 2022
url http://irep.iium.edu.my/103818/1/103818_Evaluation%20and%20characterization%20of%20hard-shell%20capsules.pdf
http://irep.iium.edu.my/103818/2/103818_Evaluation%20and%20characterization%20of%20hard-shell%20capsules_SCOPUS.pdf
http://irep.iium.edu.my/103818/
https://www.mdpi.com/2073-4360/14/20/4416
_version_ 1759689245483597824
score 13.211869

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