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An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review

In recent years, mucoadhesive topical application of mucous membrane has gained considerable interest among formulation researchers in advanced drug delivery systems. It has been identified as a potential route for both local and systemic drug delivery. A mucoadhesive agent is usually i...

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Main Authors: Mohammad Hamdi, Nurul Ain, Azmi, Nurul Atifah, Mohd Sabari, Nurul Hanis, Harun @ Ismail, Ahmad Fahmi, Haris @ Harith, Muhammad Salahuddin
Format: Article
Language:English
Published: IIUM Press 2023
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/103523/2/103523_An%20insight%20into%20the%20use%20and%20advantages.pdf
http://irep.iium.edu.my/103523/
https://journals.iium.edu.my/ktn/index.php/jp/article/view/156
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spelling my.iium.irep.1035232023-11-24T09:06:33Z http://irep.iium.edu.my/103523/ An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review Mohammad Hamdi, Nurul Ain Azmi, Nurul Atifah Mohd Sabari, Nurul Hanis Harun @ Ismail, Ahmad Fahmi Haris @ Harith, Muhammad Salahuddin RS Pharmacy and materia medica In recent years, mucoadhesive topical application of mucous membrane has gained considerable interest among formulation researchers in advanced drug delivery systems. It has been identified as a potential route for both local and systemic drug delivery. A mucoadhesive agent is usually incorporated in the formulation to overcome the disadvantages associated with the conventional topical formulation. These disadvantages include low residence time of the medication on the site of application due to tongue movement and salivary washout in the intraoral formulation, mucociliary clearance in the intranasal application, and rapid precorneal elimination in the intraocular formulation. Carbomer or known as Carbopol is a mucoadhesive polymer that is widely studied for topical delivery of pharmaceutical agents to the mucous membrane. The use of Carbopol and its advantages in the mucoadhesive topical application has gained considerable interest with several published studies and is available in various grades. In this study, a systematic review was performed on the available literature that investigates the Carbopol application in mucoadhesive topical drug delivery. A systematic searching strategy was performed in Scopus, ProQuest, and PubMed databases using predetermined search strings. A total of 778 articles were retrieved, however, only 25 articles met the inclusion criteria and were used for data synthesis. The results showed that incorporation of Carbopol as mucoadhesive polymer hold multiple advantages in drug delivery namely excellent mucoadhesion effect, the prolonged residence time of the formulation, enhanced drug permeation, prolonged release of drug, pseudoplastic behaviour of the formulation, pH compatibility with all mucosal site, and biocompatible.Conclusion: This suggests that the incorporation of Carbopol can be an effective mucoadhesive agent for topical drug delivery systems. IIUM Press 2023-01-31 Article PeerReviewed application/pdf en http://irep.iium.edu.my/103523/2/103523_An%20insight%20into%20the%20use%20and%20advantages.pdf Mohammad Hamdi, Nurul Ain and Azmi, Nurul Atifah and Mohd Sabari, Nurul Hanis and Harun @ Ismail, Ahmad Fahmi and Haris @ Harith, Muhammad Salahuddin (2023) An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review. Journal of Pharmacy, 3 (1). pp. 53-65. E-ISSN 2773-5664 https://journals.iium.edu.my/ktn/index.php/jp/article/view/156 10.31436/jop.v3i1.156
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Mohammad Hamdi, Nurul Ain
Azmi, Nurul Atifah
Mohd Sabari, Nurul Hanis
Harun @ Ismail, Ahmad Fahmi
Haris @ Harith, Muhammad Salahuddin
An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review
description In recent years, mucoadhesive topical application of mucous membrane has gained considerable interest among formulation researchers in advanced drug delivery systems. It has been identified as a potential route for both local and systemic drug delivery. A mucoadhesive agent is usually incorporated in the formulation to overcome the disadvantages associated with the conventional topical formulation. These disadvantages include low residence time of the medication on the site of application due to tongue movement and salivary washout in the intraoral formulation, mucociliary clearance in the intranasal application, and rapid precorneal elimination in the intraocular formulation. Carbomer or known as Carbopol is a mucoadhesive polymer that is widely studied for topical delivery of pharmaceutical agents to the mucous membrane. The use of Carbopol and its advantages in the mucoadhesive topical application has gained considerable interest with several published studies and is available in various grades. In this study, a systematic review was performed on the available literature that investigates the Carbopol application in mucoadhesive topical drug delivery. A systematic searching strategy was performed in Scopus, ProQuest, and PubMed databases using predetermined search strings. A total of 778 articles were retrieved, however, only 25 articles met the inclusion criteria and were used for data synthesis. The results showed that incorporation of Carbopol as mucoadhesive polymer hold multiple advantages in drug delivery namely excellent mucoadhesion effect, the prolonged residence time of the formulation, enhanced drug permeation, prolonged release of drug, pseudoplastic behaviour of the formulation, pH compatibility with all mucosal site, and biocompatible.Conclusion: This suggests that the incorporation of Carbopol can be an effective mucoadhesive agent for topical drug delivery systems.
format Article
author Mohammad Hamdi, Nurul Ain
Azmi, Nurul Atifah
Mohd Sabari, Nurul Hanis
Harun @ Ismail, Ahmad Fahmi
Haris @ Harith, Muhammad Salahuddin
author_facet Mohammad Hamdi, Nurul Ain
Azmi, Nurul Atifah
Mohd Sabari, Nurul Hanis
Harun @ Ismail, Ahmad Fahmi
Haris @ Harith, Muhammad Salahuddin
author_sort Mohammad Hamdi, Nurul Ain
title An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review
title_short An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review
title_full An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review
title_fullStr An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review
title_full_unstemmed An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review
title_sort insight into the use and advantages of carbopol in topical mucoadhesive drug delivery system: a systematic review
publisher IIUM Press
publishDate 2023
url http://irep.iium.edu.my/103523/2/103523_An%20insight%20into%20the%20use%20and%20advantages.pdf
http://irep.iium.edu.my/103523/
https://journals.iium.edu.my/ktn/index.php/jp/article/view/156
_version_ 1783876080967352320
score 13.211869

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