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Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report

Metastatic spread of tumors to the skull is quite unusual and often represents diagnostic and therapeutic issues. Skull involvement can be observed in various neoplasms of epithelial origin and are most often due to lung, breast, thyroid, kidney and prostate cancers. However, skull metastases from h...

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Main Authors: Muhammed Nordin, Ellyda, Abdullah, Mohd Shafie
Format: Article
Language:English
Published: Kulliyyah of Medicine, International Islamic University Malaysia 2009
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/10330/1/IMJVol8No2pg47-52.pdf
http://irep.iium.edu.my/10330/
http://www.e-imj.com/
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spelling my.iium.irep.103302012-01-19T03:20:55Z http://irep.iium.edu.my/10330/ Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report Muhammed Nordin, Ellyda Abdullah, Mohd Shafie R Medicine (General) Metastatic spread of tumors to the skull is quite unusual and often represents diagnostic and therapeutic issues. Skull involvement can be observed in various neoplasms of epithelial origin and are most often due to lung, breast, thyroid, kidney and prostate cancers. However, skull metastases from hepatocellular carcinoma (HCC) have been rarely reported. The prognosis for patients with hepatocellular carcinoma is so poor that treatment of such distant metastatic lesion cannot be achieved before death occurs due to the primary malignancy. Therefore, the clinical manifestations of cranial metastasis prior to that of primary hepatocellular carcinoma have rarely been reported. This case illustrates a rare case of skull metastasis as an initial manifestation of hepatocellular carcinoma. Although a solitary skull metastasis prior to the diagnosis of HCC demonstrates rare metastatic behavior for HCC, especially in Asia, skull metastases from HCC should be included in the differential diagnosis of skull tumors, even if the patient is asymptomatic of liver cirrhosis. Kulliyyah of Medicine, International Islamic University Malaysia 2009-12-02 Article REM application/pdf en http://irep.iium.edu.my/10330/1/IMJVol8No2pg47-52.pdf Muhammed Nordin, Ellyda and Abdullah, Mohd Shafie (2009) Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report. International Medical Journal Malaysia, 8 (2). pp. 47-50. ISSN 1823-4631 http://www.e-imj.com/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Muhammed Nordin, Ellyda
Abdullah, Mohd Shafie
Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
description Metastatic spread of tumors to the skull is quite unusual and often represents diagnostic and therapeutic issues. Skull involvement can be observed in various neoplasms of epithelial origin and are most often due to lung, breast, thyroid, kidney and prostate cancers. However, skull metastases from hepatocellular carcinoma (HCC) have been rarely reported. The prognosis for patients with hepatocellular carcinoma is so poor that treatment of such distant metastatic lesion cannot be achieved before death occurs due to the primary malignancy. Therefore, the clinical manifestations of cranial metastasis prior to that of primary hepatocellular carcinoma have rarely been reported. This case illustrates a rare case of skull metastasis as an initial manifestation of hepatocellular carcinoma. Although a solitary skull metastasis prior to the diagnosis of HCC demonstrates rare metastatic behavior for HCC, especially in Asia, skull metastases from HCC should be included in the differential diagnosis of skull tumors, even if the patient is asymptomatic of liver cirrhosis.
format Article
author Muhammed Nordin, Ellyda
Abdullah, Mohd Shafie
author_facet Muhammed Nordin, Ellyda
Abdullah, Mohd Shafie
author_sort Muhammed Nordin, Ellyda
title Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_short Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_full Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_fullStr Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_full_unstemmed Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_sort solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
publisher Kulliyyah of Medicine, International Islamic University Malaysia
publishDate 2009
url http://irep.iium.edu.my/10330/1/IMJVol8No2pg47-52.pdf
http://irep.iium.edu.my/10330/
http://www.e-imj.com/
_version_ 1643606357792784384
score 13.211869

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