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Assessment of liver acute toxicity in mice of the God’s crown extract

God’s crown (GC) is a traditional herbal plant that grows all year long. It is widely available throughout the Southeast Asian region, with the highest concentrations in Malaysia, Indonesia, and Oceania. In traditional and complementary medicine various parts of GC have been used effectively in...

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Main Authors: Abdur Rashid, Mohammad, Sarker, Md. Zaidul Islam, Ahmed, Qamar Uddin, Ferdosh, Sahena, Helal Uddin, A.B.M.
Format: Conference or Workshop Item
Language:English
Published: 2021
Subjects:
QD Chemistry
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:http://irep.iium.edu.my/101335/6/101335_Assessment%20of%20liver%20acute%20toxicity%20in%20mice.pdf
http://irep.iium.edu.my/101335/
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spelling my.iium.irep.1013352022-12-02T03:16:00Z http://irep.iium.edu.my/101335/ Assessment of liver acute toxicity in mice of the God’s crown extract Abdur Rashid, Mohammad Sarker, Md. Zaidul Islam Ahmed, Qamar Uddin Ferdosh, Sahena Helal Uddin, A.B.M. QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry God’s crown (GC) is a traditional herbal plant that grows all year long. It is widely available throughout the Southeast Asian region, with the highest concentrations in Malaysia, Indonesia, and Oceania. In traditional and complementary medicine various parts of GC have been used effectively in preventing and controlling symptoms of different diseases such as kidney, diabetes, stroke, haemorrhoids, cancer, migraine, impotence, allergies, heart disease, acne, and other skin problems. The use of herbal products in a safe manner is extremely important for human beings. But there are still insufficient data on GC acute toxicity and safety. As a result, toxicological testing of GC extracts in experimental animals is a requirement for clinical trials and future therapeutic applications. The aim of this research was to analyze the acute toxicity in the mice model of GC extract. The subcritical extract of GC was designed and administrated in mice for the evaluation of acute toxicity and hepatoprotective activity according to the OECD guidelines 425. The liver function parameters such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), total protein (TP), alanine aminotransferase (ALT), and morphological observation of liver tissue were analyzed consequently. The subcritical extract did not show any mortality and no changes in general behavior up to a dose of 3000 mg/kg body weight (3000mg/kg>LD 50 ). The histopathological profile of the extract-treated liver tissue demonstrated similar morphology as that of normal controls at doses 500 mg/kg body weight. On the other hand, acute toxicity is reflected by the various investigated parameters apart from mild liver histopathological inflammatory changes which reflect mild liver injury induced by the 1000mg/kg body weight. As a result, when developing GC-based phytomedicine, it is important to consider the selection of an appropriate dose that will provide better activity while minimizing adverse side effects. 2021 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/101335/6/101335_Assessment%20of%20liver%20acute%20toxicity%20in%20mice.pdf Abdur Rashid, Mohammad and Sarker, Md. Zaidul Islam and Ahmed, Qamar Uddin and Ferdosh, Sahena and Helal Uddin, A.B.M. (2021) Assessment of liver acute toxicity in mice of the God’s crown extract. In: Asian Symposium on Medicinal Plants and Spices XVII (2021), 18-19 August 2021, Putrajaya, Malaysia. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QD Chemistry
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle QD Chemistry
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RS403 Materia Medica-Pharmaceutical Chemistry
Abdur Rashid, Mohammad
Sarker, Md. Zaidul Islam
Ahmed, Qamar Uddin
Ferdosh, Sahena
Helal Uddin, A.B.M.
Assessment of liver acute toxicity in mice of the God’s crown extract
description God’s crown (GC) is a traditional herbal plant that grows all year long. It is widely available throughout the Southeast Asian region, with the highest concentrations in Malaysia, Indonesia, and Oceania. In traditional and complementary medicine various parts of GC have been used effectively in preventing and controlling symptoms of different diseases such as kidney, diabetes, stroke, haemorrhoids, cancer, migraine, impotence, allergies, heart disease, acne, and other skin problems. The use of herbal products in a safe manner is extremely important for human beings. But there are still insufficient data on GC acute toxicity and safety. As a result, toxicological testing of GC extracts in experimental animals is a requirement for clinical trials and future therapeutic applications. The aim of this research was to analyze the acute toxicity in the mice model of GC extract. The subcritical extract of GC was designed and administrated in mice for the evaluation of acute toxicity and hepatoprotective activity according to the OECD guidelines 425. The liver function parameters such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), total protein (TP), alanine aminotransferase (ALT), and morphological observation of liver tissue were analyzed consequently. The subcritical extract did not show any mortality and no changes in general behavior up to a dose of 3000 mg/kg body weight (3000mg/kg>LD 50 ). The histopathological profile of the extract-treated liver tissue demonstrated similar morphology as that of normal controls at doses 500 mg/kg body weight. On the other hand, acute toxicity is reflected by the various investigated parameters apart from mild liver histopathological inflammatory changes which reflect mild liver injury induced by the 1000mg/kg body weight. As a result, when developing GC-based phytomedicine, it is important to consider the selection of an appropriate dose that will provide better activity while minimizing adverse side effects.
format Conference or Workshop Item
author Abdur Rashid, Mohammad
Sarker, Md. Zaidul Islam
Ahmed, Qamar Uddin
Ferdosh, Sahena
Helal Uddin, A.B.M.
author_facet Abdur Rashid, Mohammad
Sarker, Md. Zaidul Islam
Ahmed, Qamar Uddin
Ferdosh, Sahena
Helal Uddin, A.B.M.
author_sort Abdur Rashid, Mohammad
title Assessment of liver acute toxicity in mice of the God’s crown extract
title_short Assessment of liver acute toxicity in mice of the God’s crown extract
title_full Assessment of liver acute toxicity in mice of the God’s crown extract
title_fullStr Assessment of liver acute toxicity in mice of the God’s crown extract
title_full_unstemmed Assessment of liver acute toxicity in mice of the God’s crown extract
title_sort assessment of liver acute toxicity in mice of the god’s crown extract
publishDate 2021
url http://irep.iium.edu.my/101335/6/101335_Assessment%20of%20liver%20acute%20toxicity%20in%20mice.pdf
http://irep.iium.edu.my/101335/
_version_ 1751535927791976448
score 13.211869

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