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Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants

The emergence of antimicrobial-resistant pathogens has led to a decline in the availability of effective medications for clinical use, which urges the development of new drugs. N-acylhydrazone (NAH) with its versatile chemical moiety becomes essential in designing new drugs as its derivatives have b...

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Main Author: Chan, Yao Xiang
Format: Final Year Project / Dissertation / Thesis
Published: 2024
Subjects:
Q Science (General)
Online Access:http://eprints.utar.edu.my/6851/1/Chan_Yao_Xiang_FD_FYP_Thesis_%2D_YAO_XIANG_CHAN.pdf
http://eprints.utar.edu.my/6851/
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spelling my-utar-eprints.68512025-02-23T07:23:52Z Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants Chan, Yao Xiang Q Science (General) The emergence of antimicrobial-resistant pathogens has led to a decline in the availability of effective medications for clinical use, which urges the development of new drugs. N-acylhydrazone (NAH) with its versatile chemical moiety becomes essential in designing new drugs as its derivatives have been approved as therapeutics. This project studied the in vitro antibacterial activity of 7 NAH derivative compounds with different aromatic substitutions at ortho and para directors individually and in combination with 3 standard drugs as adjuvants against 8 bacterial strains using the broth microdilution method to determine Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The results revealed that Compounds 1 (2-Br), 4 (H), 6 (2-OCH3) and 7 (2,4-Cl2) exhibited moderately active antibacterial activity against Staphylococcus aureus (ATCC 6538) with a MIC value of 62.5 μg/mL, showing species-specific antibacterial activity. With the combination of antibiotics as adjuvants, the NAH derivative compounds demonstrated enhanced antibacterial activities. Notably, the ciprofloxacin-NAH adjuvant combinations obtained MBC/MIC ratio ranging from 1 to 4, suggesting the bactericidal effects. Nevertheless, the Fractional Inhibitory Concentration (FIC) index calculated revealed that neither of the antibiotic-NAH adjuvant combinations was suitable for further studies although synergism was observed because most of the combinations recorded insignificant interactions, indicating the antibacterial activity was contributed by the antibiotic itself. 2024-05 Final Year Project / Dissertation / Thesis NonPeerReviewed application/pdf http://eprints.utar.edu.my/6851/1/Chan_Yao_Xiang_FD_FYP_Thesis_%2D_YAO_XIANG_CHAN.pdf Chan, Yao Xiang (2024) Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants. Final Year Project, UTAR. http://eprints.utar.edu.my/6851/
institution Universiti Tunku Abdul Rahman
building UTAR Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tunku Abdul Rahman
content_source UTAR Institutional Repository
url_provider http://eprints.utar.edu.my
topic Q Science (General)
spellingShingle Q Science (General)
Chan, Yao Xiang
Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants
description The emergence of antimicrobial-resistant pathogens has led to a decline in the availability of effective medications for clinical use, which urges the development of new drugs. N-acylhydrazone (NAH) with its versatile chemical moiety becomes essential in designing new drugs as its derivatives have been approved as therapeutics. This project studied the in vitro antibacterial activity of 7 NAH derivative compounds with different aromatic substitutions at ortho and para directors individually and in combination with 3 standard drugs as adjuvants against 8 bacterial strains using the broth microdilution method to determine Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The results revealed that Compounds 1 (2-Br), 4 (H), 6 (2-OCH3) and 7 (2,4-Cl2) exhibited moderately active antibacterial activity against Staphylococcus aureus (ATCC 6538) with a MIC value of 62.5 μg/mL, showing species-specific antibacterial activity. With the combination of antibiotics as adjuvants, the NAH derivative compounds demonstrated enhanced antibacterial activities. Notably, the ciprofloxacin-NAH adjuvant combinations obtained MBC/MIC ratio ranging from 1 to 4, suggesting the bactericidal effects. Nevertheless, the Fractional Inhibitory Concentration (FIC) index calculated revealed that neither of the antibiotic-NAH adjuvant combinations was suitable for further studies although synergism was observed because most of the combinations recorded insignificant interactions, indicating the antibacterial activity was contributed by the antibiotic itself.
format Final Year Project / Dissertation / Thesis
author Chan, Yao Xiang
author_facet Chan, Yao Xiang
author_sort Chan, Yao Xiang
title Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants
title_short Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants
title_full Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants
title_fullStr Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants
title_full_unstemmed Antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants
title_sort antibacterial activity of 5-chloro substituted phenyl n-acylhydrazones with aromatic substitution at ortho- and para-directors as potent adjuvants
publishDate 2024
url http://eprints.utar.edu.my/6851/1/Chan_Yao_Xiang_FD_FYP_Thesis_%2D_YAO_XIANG_CHAN.pdf
http://eprints.utar.edu.my/6851/
_version_ 1825167459924049920
score 13.239859

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