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Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique

Colloidal instability has prevented widespread usage of magnetic nanoparticles (MNPs) in a variety of engineering applications. The colloidal stability of MNPs can be enhanced by surface modification or functionalization with polyelectrolytes, however it is still difficult to determine the ideal fun...

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Main Author: Chan, Wei Jie
Format: Final Year Project / Dissertation / Thesis
Published: 2023
Subjects:
T Technology (General)
TP Chemical technology
Online Access:http://eprints.utar.edu.my/5618/1/fyp_PE_2023_CWJ.pdf
http://eprints.utar.edu.my/5618/
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spelling my-utar-eprints.56182023-08-16T11:31:14Z Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique Chan, Wei Jie T Technology (General) TP Chemical technology Colloidal instability has prevented widespread usage of magnetic nanoparticles (MNPs) in a variety of engineering applications. The colloidal stability of MNPs can be enhanced by surface modification or functionalization with polyelectrolytes, however it is still difficult to determine the ideal functionalization conditions for generating the most stable MNP systems. This research overcomes this obstacle by examining the average particle size and particle size distribution of MNP systems produced by altering the mass ratio of polyelectrolyte (PSS) to MNPs during surface functionalization. According to the results, the lowest average hydrodynamic size and narrowest particle size distribution were achieved in an MNP system where the mass ratio of MNPs to polyelectrolyte (PSS) was 1:1. Also, the study presented the Continuous-Flow Low-Gradient Magnetic Separation (CF-LGMS) method of making MNPs with enhanced monodispersity. This investigation conducted an experimental investigation into how flowrate and magnet configurations affect the monodispersity of CF-LGMS-fractionated systems of magnetic nanoparticles. The results demonstrated that the size fractionation of MNPs via the CF-LGMS process was greatly enhanced by a slower flowrate (5 ml/min) and a higher quantity of magnets (dual pair magnet arrangement), resulting in a monodispersed MNP system. Eventually, the study used COMSOL Multiphysics to create a mathematical model of the CF-LGMS fractionation process. The model's ability to predict and optimise the performance of the CF-LGMS process was demonstrated by the high degree of agreement between the simulated and experimental findings. Many engineering applications, including as MRI, drug administration, and magnetic hyperthermia, rely ix on MNPs with high colloidal stability and monodispersity, and this work contributes to that knowledge 2023-01 Final Year Project / Dissertation / Thesis NonPeerReviewed application/pdf http://eprints.utar.edu.my/5618/1/fyp_PE_2023_CWJ.pdf Chan, Wei Jie (2023) Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique. Final Year Project, UTAR. http://eprints.utar.edu.my/5618/
institution Universiti Tunku Abdul Rahman
building UTAR Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tunku Abdul Rahman
content_source UTAR Institutional Repository
url_provider http://eprints.utar.edu.my
topic T Technology (General)
TP Chemical technology
spellingShingle T Technology (General)
TP Chemical technology
Chan, Wei Jie
Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique
description Colloidal instability has prevented widespread usage of magnetic nanoparticles (MNPs) in a variety of engineering applications. The colloidal stability of MNPs can be enhanced by surface modification or functionalization with polyelectrolytes, however it is still difficult to determine the ideal functionalization conditions for generating the most stable MNP systems. This research overcomes this obstacle by examining the average particle size and particle size distribution of MNP systems produced by altering the mass ratio of polyelectrolyte (PSS) to MNPs during surface functionalization. According to the results, the lowest average hydrodynamic size and narrowest particle size distribution were achieved in an MNP system where the mass ratio of MNPs to polyelectrolyte (PSS) was 1:1. Also, the study presented the Continuous-Flow Low-Gradient Magnetic Separation (CF-LGMS) method of making MNPs with enhanced monodispersity. This investigation conducted an experimental investigation into how flowrate and magnet configurations affect the monodispersity of CF-LGMS-fractionated systems of magnetic nanoparticles. The results demonstrated that the size fractionation of MNPs via the CF-LGMS process was greatly enhanced by a slower flowrate (5 ml/min) and a higher quantity of magnets (dual pair magnet arrangement), resulting in a monodispersed MNP system. Eventually, the study used COMSOL Multiphysics to create a mathematical model of the CF-LGMS fractionation process. The model's ability to predict and optimise the performance of the CF-LGMS process was demonstrated by the high degree of agreement between the simulated and experimental findings. Many engineering applications, including as MRI, drug administration, and magnetic hyperthermia, rely ix on MNPs with high colloidal stability and monodispersity, and this work contributes to that knowledge
format Final Year Project / Dissertation / Thesis
author Chan, Wei Jie
author_facet Chan, Wei Jie
author_sort Chan, Wei Jie
title Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique
title_short Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique
title_full Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique
title_fullStr Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique
title_full_unstemmed Size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique
title_sort size fractionation of magnetic nanoparticles by using continuous flow low gradient magnetic separation technique
publishDate 2023
url http://eprints.utar.edu.my/5618/1/fyp_PE_2023_CWJ.pdf
http://eprints.utar.edu.my/5618/
_version_ 1775627978806394880
score 13.211869

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