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α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves

Aquilaria sp. belongs to Thymelaeaceae family. This genus produces a unique fragrant wood locally known as ‘gaharu’. It is well known for usages in aromatherapy while very few scientific evidence on its usage as herbal medicine have been published. The current study was therefore conducted to dete...

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Main Authors: Zalilawati, Mat Rashid, Nor Hasima, Mahmod, Nur Nasyitah, Mohd Nasir
Format: Article
Language:English
English
English
Published: 2020
Subjects:
QD Chemistry
Online Access:http://eprints.unisza.edu.my/7279/1/FH02-FBIM-20-43365.pdf
http://eprints.unisza.edu.my/7279/2/FH02-FBIM-20-47845.pdf
http://eprints.unisza.edu.my/7279/3/FH02-FBIM-20-49372.pdf
http://eprints.unisza.edu.my/7279/
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spelling my-unisza-ir.72792022-05-24T04:51:45Z http://eprints.unisza.edu.my/7279/ α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves Zalilawati, Mat Rashid Nor Hasima, Mahmod Nur Nasyitah, Mohd Nasir QD Chemistry Aquilaria sp. belongs to Thymelaeaceae family. This genus produces a unique fragrant wood locally known as ‘gaharu’. It is well known for usages in aromatherapy while very few scientific evidence on its usage as herbal medicine have been published. The current study was therefore conducted to determine the chemical characteristics as well as antioxidant and α-glucosidase inhibition potential of carbohydrate-rich extracts (aqueous and polysaccharide extracts) from three Aquilaria species leaves (A. malaccensis, A. sinensis and A. subintegra). The isolation of polysaccharide (PS) from the aqueous extract (AE) was conducted by ethanol precipitation prior to ultrasonic-assisted extraction. The total phenolic content (TPC), proximate and Fourier Transform Infrared Spectroscopy (FTIR) analysis were carried out to investigate the chemical characteristics, while the bioactivities determined were 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and αglucosidase inhibition. As a result, AE of A. malaccensis leaves showed the strongest α-glucosidase (IC50: 0.038 mg/mL) and DPPH (IC50: 0.084 mg/mL) inhibition while contained more TPC (61.16 mg GAE/g) compared to other two species. Furthermore, PS of A. malaccensis leaves displayed even stronger α-glucosidase inhibition (IC50: 0.014 mg/mL) compared to its respective AE and other PS. In conclusion, this study primarily revealed the scientific evidence on the bioactive potential of PS of Aquilaria sp. 2020-12 Article PeerReviewed text en http://eprints.unisza.edu.my/7279/1/FH02-FBIM-20-43365.pdf text en http://eprints.unisza.edu.my/7279/2/FH02-FBIM-20-47845.pdf text en http://eprints.unisza.edu.my/7279/3/FH02-FBIM-20-49372.pdf Zalilawati, Mat Rashid and Nor Hasima, Mahmod and Nur Nasyitah, Mohd Nasir (2020) α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves. Journal of Agrobiotechnology, 11 (2). pp. 59-69. ISSN 2180-1983
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
English
English
topic QD Chemistry
spellingShingle QD Chemistry
Zalilawati, Mat Rashid
Nor Hasima, Mahmod
Nur Nasyitah, Mohd Nasir
α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves
description Aquilaria sp. belongs to Thymelaeaceae family. This genus produces a unique fragrant wood locally known as ‘gaharu’. It is well known for usages in aromatherapy while very few scientific evidence on its usage as herbal medicine have been published. The current study was therefore conducted to determine the chemical characteristics as well as antioxidant and α-glucosidase inhibition potential of carbohydrate-rich extracts (aqueous and polysaccharide extracts) from three Aquilaria species leaves (A. malaccensis, A. sinensis and A. subintegra). The isolation of polysaccharide (PS) from the aqueous extract (AE) was conducted by ethanol precipitation prior to ultrasonic-assisted extraction. The total phenolic content (TPC), proximate and Fourier Transform Infrared Spectroscopy (FTIR) analysis were carried out to investigate the chemical characteristics, while the bioactivities determined were 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and αglucosidase inhibition. As a result, AE of A. malaccensis leaves showed the strongest α-glucosidase (IC50: 0.038 mg/mL) and DPPH (IC50: 0.084 mg/mL) inhibition while contained more TPC (61.16 mg GAE/g) compared to other two species. Furthermore, PS of A. malaccensis leaves displayed even stronger α-glucosidase inhibition (IC50: 0.014 mg/mL) compared to its respective AE and other PS. In conclusion, this study primarily revealed the scientific evidence on the bioactive potential of PS of Aquilaria sp.
format Article
author Zalilawati, Mat Rashid
Nor Hasima, Mahmod
Nur Nasyitah, Mohd Nasir
author_facet Zalilawati, Mat Rashid
Nor Hasima, Mahmod
Nur Nasyitah, Mohd Nasir
author_sort Zalilawati, Mat Rashid
title α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves
title_short α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves
title_full α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves
title_fullStr α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves
title_full_unstemmed α-glucosidase Inhibition, DPPH Scavenging activities and Chemical Analysis of Polysaccharide Extracts from Aquilaria sp. Leaves
title_sort α-glucosidase inhibition, dpph scavenging activities and chemical analysis of polysaccharide extracts from aquilaria sp. leaves
publishDate 2020
url http://eprints.unisza.edu.my/7279/1/FH02-FBIM-20-43365.pdf
http://eprints.unisza.edu.my/7279/2/FH02-FBIM-20-47845.pdf
http://eprints.unisza.edu.my/7279/3/FH02-FBIM-20-49372.pdf
http://eprints.unisza.edu.my/7279/
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score 13.211869

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