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Drug interaction and its implication in clinical practice and personalized medicine

In personalized medicine, the appropriate drugs for an individual patient are selected based on the patient’s medical history, diagnostic testing, and genetic information for the purpose of minimizing drug interactions (DIs), side effects, and adverse drug reactions (ADRs) and to obtain the maximum...

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Main Authors: Mainul, Haque, Abdullahi Rabiu, Abubakar, Basheer, Chedi
Format: Article
Language:English
English
Published: 2015
Subjects:
QH301 Biology
R Medicine (General)
Online Access:http://eprints.unisza.edu.my/6592/1/FH02-FP-15-03726.pdf
http://eprints.unisza.edu.my/6592/2/FH02-FP-16-05529.jpg
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spelling my-unisza-ir.65922022-09-13T04:45:24Z http://eprints.unisza.edu.my/6592/ Drug interaction and its implication in clinical practice and personalized medicine Mainul, Haque Abdullahi Rabiu, Abubakar Basheer, Chedi QH301 Biology R Medicine (General) In personalized medicine, the appropriate drugs for an individual patient are selected based on the patient’s medical history, diagnostic testing, and genetic information for the purpose of minimizing drug interactions (DIs), side effects, and adverse drug reactions (ADRs) and to obtain the maximum therapeutic benefit. The DI is one of the major problems of pharmacotherapy, which perhaps leads to adverse outcome or therapeutic failure if not properly addressed. In clinical practice, patient safety is likely to improve through the identification of frequently occurring DIs by pharmacist and notifying the other members of the health-care team. Recently, a software was introduced, which detects DIs with good precision; however, this software requires a constant update. Health-care professionals require adequate knowledge and skills on how to identify and avoid DIs to enable them complement the software assessment. Basically, DIs include drug–drug, drug–food, drug–herbal, and drug–disease interactions. These possibilities can be identified from chemical properties, pharmacokinetics, and pharmacodynamics of the drug, patient medical history, concomitant disease, or organ failure. Focusing on DIs will help to reduce drug-related problems, advance the evidence-based medicine, and improve the level of patient satisfaction. Adequate knowledge of drug DIs will enable the health-care professionals to individualize the patient treatment in order to get maximum therapeutic benefit. This script is aimed at describing the various classes of DIs, their causes, and their implications in clinical practice and personalized medicine. 2015 Article PeerReviewed text en http://eprints.unisza.edu.my/6592/1/FH02-FP-15-03726.pdf image en http://eprints.unisza.edu.my/6592/2/FH02-FP-16-05529.jpg Mainul, Haque and Abdullahi Rabiu, Abubakar and Basheer, Chedi (2015) Drug interaction and its implication in clinical practice and personalized medicine. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5). pp. 1-7. ISSN 2231-3206
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
English
topic QH301 Biology
R Medicine (General)
spellingShingle QH301 Biology
R Medicine (General)
Mainul, Haque
Abdullahi Rabiu, Abubakar
Basheer, Chedi
Drug interaction and its implication in clinical practice and personalized medicine
description In personalized medicine, the appropriate drugs for an individual patient are selected based on the patient’s medical history, diagnostic testing, and genetic information for the purpose of minimizing drug interactions (DIs), side effects, and adverse drug reactions (ADRs) and to obtain the maximum therapeutic benefit. The DI is one of the major problems of pharmacotherapy, which perhaps leads to adverse outcome or therapeutic failure if not properly addressed. In clinical practice, patient safety is likely to improve through the identification of frequently occurring DIs by pharmacist and notifying the other members of the health-care team. Recently, a software was introduced, which detects DIs with good precision; however, this software requires a constant update. Health-care professionals require adequate knowledge and skills on how to identify and avoid DIs to enable them complement the software assessment. Basically, DIs include drug–drug, drug–food, drug–herbal, and drug–disease interactions. These possibilities can be identified from chemical properties, pharmacokinetics, and pharmacodynamics of the drug, patient medical history, concomitant disease, or organ failure. Focusing on DIs will help to reduce drug-related problems, advance the evidence-based medicine, and improve the level of patient satisfaction. Adequate knowledge of drug DIs will enable the health-care professionals to individualize the patient treatment in order to get maximum therapeutic benefit. This script is aimed at describing the various classes of DIs, their causes, and their implications in clinical practice and personalized medicine.
format Article
author Mainul, Haque
Abdullahi Rabiu, Abubakar
Basheer, Chedi
author_facet Mainul, Haque
Abdullahi Rabiu, Abubakar
Basheer, Chedi
author_sort Mainul, Haque
title Drug interaction and its implication in clinical practice and personalized medicine
title_short Drug interaction and its implication in clinical practice and personalized medicine
title_full Drug interaction and its implication in clinical practice and personalized medicine
title_fullStr Drug interaction and its implication in clinical practice and personalized medicine
title_full_unstemmed Drug interaction and its implication in clinical practice and personalized medicine
title_sort drug interaction and its implication in clinical practice and personalized medicine
publishDate 2015
url http://eprints.unisza.edu.my/6592/1/FH02-FP-15-03726.pdf
http://eprints.unisza.edu.my/6592/2/FH02-FP-16-05529.jpg
http://eprints.unisza.edu.my/6592/
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score 13.211869

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