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Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer

Objective: To assess the efficacy of inhaled ginger aromatherapy on nausea, vomiting and health-related quality of life (HRQoL) in chemotherapy breast cancer patients. Design: Single-blind, controlled, randomized cross-over study. Patients received 5-day aromatherapy treatment using either ginger es...

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Main Authors: Pei Lin, Lua, Noor Salihah, Zakaria, Nik Mazlan, Mamat
Format: Article
Language:English
English
Published: Churchill Livingstone 2015
Subjects:
BF Psychology
R Medicine (General)
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spelling my-unisza-ir.65172022-09-13T04:47:42Z http://eprints.unisza.edu.my/6517/ Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer Pei Lin, Lua Noor Salihah, Zakaria Nik Mazlan, Mamat BF Psychology R Medicine (General) Objective: To assess the efficacy of inhaled ginger aromatherapy on nausea, vomiting and health-related quality of life (HRQoL) in chemotherapy breast cancer patients. Design: Single-blind, controlled, randomized cross-over study. Patients received 5-day aromatherapy treatment using either ginger essential oil or fragrance-matched artificial placebo (ginger fragrance oil) which was instilled in a necklace in an order dictated by the treatment group sequence. Setting: Two oncology clinics in the East Coast of Peninsular Malaysia. Main outcome measures: VAS nausea score, frequency of vomiting and HRQoL profile (EORTC QLQ-C30 scores). Results: Sixty female patients completed the study (age = 47.3 ± 9.26 years; Malay = 98.3%; on highly emetogenic chemotherapy = 86.7%). The VAS nausea score was significantly lower after ginger essential oil inhalation compared to placebo during acute phase (P = 0.040) but not sustained for overall treatment effect (treatment effect: F = 1.82, P = 0.183; time effect: F = 43.98, P < 0.001; treatment × time effect: F = 2.04; P = 0.102). Similarly, there was no significant effect of aromatherapy on vomiting [F(1, 58) = 0.29, P = 0.594]. However, a statistically significant change from baseline for global health status (P < 0.001) was detected after ginger essential oil inhalation. A clinically relevant 10 points improvement on role functioning (P = 0.002) and appetite loss (P < 0.001) were also documented while patients were on ginger essential oil. Conclusion: At present time, the evidence derived from this study is not sufficiently convincing that inhaled ginger aromatherapy is an effective complementary therapy for CINV. The findings for HRQoL were however encouraging with significant improvement in several domains. Churchill Livingstone 2015-06 Article PeerReviewed image en http://eprints.unisza.edu.my/6517/1/FH02-FSK-15-03647.jpg image en http://eprints.unisza.edu.my/6517/2/FH02-FSK-15-03768.jpg Pei Lin, Lua and Noor Salihah, Zakaria and Nik Mazlan, Mamat (2015) Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer. Complementary Therapies in Medicine, 23 (3). pp. 396-404. ISSN 09652299
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
English
topic BF Psychology
R Medicine (General)
spellingShingle BF Psychology
R Medicine (General)
Pei Lin, Lua
Noor Salihah, Zakaria
Nik Mazlan, Mamat
Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer
description Objective: To assess the efficacy of inhaled ginger aromatherapy on nausea, vomiting and health-related quality of life (HRQoL) in chemotherapy breast cancer patients. Design: Single-blind, controlled, randomized cross-over study. Patients received 5-day aromatherapy treatment using either ginger essential oil or fragrance-matched artificial placebo (ginger fragrance oil) which was instilled in a necklace in an order dictated by the treatment group sequence. Setting: Two oncology clinics in the East Coast of Peninsular Malaysia. Main outcome measures: VAS nausea score, frequency of vomiting and HRQoL profile (EORTC QLQ-C30 scores). Results: Sixty female patients completed the study (age = 47.3 ± 9.26 years; Malay = 98.3%; on highly emetogenic chemotherapy = 86.7%). The VAS nausea score was significantly lower after ginger essential oil inhalation compared to placebo during acute phase (P = 0.040) but not sustained for overall treatment effect (treatment effect: F = 1.82, P = 0.183; time effect: F = 43.98, P < 0.001; treatment × time effect: F = 2.04; P = 0.102). Similarly, there was no significant effect of aromatherapy on vomiting [F(1, 58) = 0.29, P = 0.594]. However, a statistically significant change from baseline for global health status (P < 0.001) was detected after ginger essential oil inhalation. A clinically relevant 10 points improvement on role functioning (P = 0.002) and appetite loss (P < 0.001) were also documented while patients were on ginger essential oil. Conclusion: At present time, the evidence derived from this study is not sufficiently convincing that inhaled ginger aromatherapy is an effective complementary therapy for CINV. The findings for HRQoL were however encouraging with significant improvement in several domains.
format Article
author Pei Lin, Lua
Noor Salihah, Zakaria
Nik Mazlan, Mamat
author_facet Pei Lin, Lua
Noor Salihah, Zakaria
Nik Mazlan, Mamat
author_sort Pei Lin, Lua
title Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer
title_short Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer
title_full Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer
title_fullStr Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer
title_full_unstemmed Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer
title_sort effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer
publisher Churchill Livingstone
publishDate 2015
url http://eprints.unisza.edu.my/6517/1/FH02-FSK-15-03647.jpg
http://eprints.unisza.edu.my/6517/2/FH02-FSK-15-03768.jpg
http://eprints.unisza.edu.my/6517/
_version_ 1744358556335865856
score 13.211869

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